Proteins (Proteins, Gene)

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

Also Known As:

Networked: 90489 relevant articles (1469 outcomes, 8318 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Wei: 85 articles (01/2016 - 04/2002)
2.	Li, Wei: 79 articles (10/2015 - 03/2002)
3.	Wang, Wei: 63 articles (12/2015 - 10/2004)
4.	Li, Yan: 62 articles (12/2015 - 01/2002)
5.	Butterfield, D Allan: 61 articles (10/2014 - 05/2002)
6.	Zhang, Jing: 54 articles (09/2015 - 09/2004)
7.	Li, Li: 52 articles (11/2015 - 02/2002)
8.	Smith, Richard D: 51 articles (09/2015 - 07/2003)
9.	Reed, John C: 51 articles (07/2015 - 01/2002)
10.	Pandey, Akhilesh: 50 articles (09/2015 - 02/2004)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2015 - "Insights into the functioning of the centrosomal proteins will be extremely beneficial in validating the centrosome as a target in cancer therapy. " 06/01/2011 - "Suggested to be one of the most cancer-specific proteins identified to date, survivin acts as a signalling node in tumour maintenance and, after first promising results, is now attracting increasing attention as a target in anti-cancer therapy. " 01/01/2011 - "Targeted expression of desired therapeutic proteins within the tumor is the best approach to reduce toxicity and improve survival. " 03/01/2005 - "The ability to identify activated pathways that drive the growth and progression of cancer and to develop specific and potent inhibitors of key proteins in these pathways promises to dramatically change the treatment of cancer: A patient's cancer could be characterized at the molecular level and the information used to select the best treatment options. " 11/01/1996 - "We have shown that the expression of junctional plaque proteins is modulated during growth stimulation and differentiation, and is dramatically reduced in certain tumor cells. "
2.	Infection 02/01/1998 - "Ongoing clinical trials show that ACVs are clearly less reactogenic than WCVs and that ACVs comprised of three to five proteins are highly efficacious in inducing protection against Bordetella pertussis infections. " 06/01/2001 - "The non-structural 3 (NS3) protein is one of the most conserved proteins of hepatitis C virus, and T helper 1 (Th1)-like responses to NS3 in humans correlate with clearance of infection. " 07/11/2013 - "Consecutive immunization with rGGT followed by rUreB and immunization with the bivalent vaccine improved the protective efficacy compared to immunization with single proteins, with a complete clearance of infection observed in 50% of the animals. " 10/01/2006 - "leucopus, separate incorporation of these fusion proteins in an ELISA was very helpful in confirming past or current infections and in identifying specific foci for B. " 10/01/2006 - "However, proteins that afford protection against ROS may play an important role in the survival of the macrophage to LeTx infection as shown by the differences in proteomic responses of the two cell lines to the action of LeTx. "
3.	Inflammation 01/01/2009 - "Inflammation was associated with a significant reduction in both beta1-AR and NET density with a positive correlation between the two proteins (r=0.978, p<0.0001). " 11/01/2010 - "The Nrf2-signaling pathway mediates multiple avenues of cytoprotection by activating the transcription of more than 200 genes that are crucial in the metabolism of drugs and toxins, protection against oxidative stress and inflammation, as well as playing an integral role in stability of proteins and in the removal of damaged proteins via proteasomal degradation or autophagy. " 07/23/2015 - "Our results indicated that TM has protective effects on preserving microvascular integrity following SAH partly through preserving endothelial junction proteins and quenching apoptosis/inflammation in endothelial cells via blocking p38MAPK-p53/NF-κB (p65) pathway." 03/01/2004 - "This study was undertaken to test the hypothesis that changes in growth-related proteins are related to decreased inflammation, rather than improvement in nutritional status. " 12/05/2014 - "Monitoring proteins involved in regulatory effects may help to improve our understanding of inflammation. "
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 05/01/2014 - "Emerging studies have demonstrated that up-regulation of autophagy can lead to decreased levels of these toxic aggregate-prone proteins, and is beneficial in the context of aging and various models of neurodegenerative diseases. " 01/01/2005 - "Studies of proteins, cells, animal models, and humans suggest that treatments to diminish, or bypass, the reduction in KGDHC might be beneficial in age-related neurodegenerative disorders." 05/01/2014 - "Defect of autophagy is common to many neurodegenerative disorders because it serves as a major degradation pathway for the clearance of various aggregate-prone proteins. " 01/01/2014 - "Both cellular systems responsible for clearance of misfolded and aggregated proteins, the lysosomal and the proteasomal, have been shown to be malfunctioning in the aged brain and more so in patients with neurodegenerative diseases, including AD. " 08/01/2015 - "Its induction may accelerate the clearance of pathogenic proteins and promote cell survival, representing a potential therapeutic approach for the treatment of neurodegenerative diseases. "
5.	Breast Neoplasms (Breast Cancer) 04/19/2007 - "Compound 7 is highly effective in induction of cell death in breast cancer cells with high levels of Bcl-2, Bcl-xL, and Mcl-1 proteins and represents a promising lead compound for the design of new anticancer drugs." 11/01/2008 - "A prognostic model on the basis of the expression of a limited number of proteins and genes may help to guide target-specific therapies in patients with high-risk breast cancer." 01/01/2015 - "This proteomic study highlights several proteins that are closely associated with early HER2-inhibitor response and will provide a valuable resource for further investigation of ways to improve efficacy of breast-cancer treatment." 07/01/2015 - "To assess the potential efficacy of VP22 as a gene therapy for breast cancer, expression vectors for N- and C-terminal PTEN-VP22 fusion proteins were constructed. " 07/01/2012 - "The WCR tandem columns allowed the capture of 113 and 112 proteins from disease-free and breast cancer sera, respectively, corresponding to 75 and 65 non-redundant proteins, respectively. "

Related Drugs and Biologics

1.	Antibodies
2.	Vaccines
3.	Antigens
4.	DNA (Deoxyribonucleic Acid)
5.	Peptides
6.	Biological Markers (Surrogate Marker)
7.	Messenger RNA (mRNA)
8.	Cytokines
9.	Glucose (Dextrose)
10.	Immunoglobulin G (IgG)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Immunotherapy
3.	Therapeutics
4.	Heterologous Transplantation (Xenotransplantation)
5.	Transplantation (Transplant Recipients)