Carrier Proteins (Binding Protein)

04/01/2014 - "Against this background, recent evidence shows that the β-galactoside-binding protein (βGBP) molecule, a physiological PI3K inhibitor, is a potent inducer of apoptosis in KRAS-mutant cancer cells (along with other aggressive cancer cells of different genetic makeup) and that it is therapeutically effective in vivo. "
06/01/2008 - "To develop an effective and safe VSV vector for cancer treatment, we tested the hypothesis that the oncolytic potency of VSV(M Delta 51) can be substantively elevated by vector-mediated expression of M3, a broad-spectrum and high-affinity chemokine-binding protein from murine gammaherpesvirus-68. "
11/01/2013 - "Kaplan-Meier analysis and Cox regression model were used to assess disease-free and overall survival, according to the expression of growth factor receptor-binding protein 14 in tumor cells. "
01/01/2014 - "This poor therapeutic efficacy may be due to insufficient drug delivery to the tumor cells and plasma protein binding. "
11/20/2013 - "The generation of drug conjugates for safe and effective tumor targeting requires binding proteins tolerant to functionalization by rational engineering. "

01/01/1992 - "These results indicate that the effect of protein binding in serum on therapeutic efficacy against intraperitoneal infection differs from that against pulmonary infection."
01/01/2012 - "The Fortilin (also known as TCTP) in Penaeus monodon (PmFortilin) and Fortilin Binding Protein 1 (FBP1) have recently been shown to interact and to offer protection against the widespread White Spot Syndrome Virus infection. "
06/01/2008 - "Taken together, the data from the present study showed that LigB is a Fn-binding protein of pathogenic Leptospira spp. and may play a pivotal role in Leptospira-host interaction during the initial stage of infection."
08/01/2007 - "Other studies have identified mu2 as a microtubule-binding protein, which also associates with the viral factory matrix protein muNS and thereby anchors the factories to cellular microtubules during infections by most reovirus strains. "
07/01/1998 - "This new approach can be used to study carbohydrate-binding proteins in the pathology of disease or infection."

05/01/2005 - "Clearance of cytokine binding proteins may be important in the resolution of inflammation. "
10/01/2015 - "ErbB3 binding protein 1 (EBP1) participates in the regulation of intestinal inflammation via mediating Akt signaling pathway."
05/19/2015 - "Epidermal Fatty Acid binding protein promotes skin inflammation induced by high-fat diet."
04/10/2015 - "The widespread expression of DPP4 on blood vessels, myocardium, and myeloid cells and the nonenzymatic function of CD26 as a signaling and binding protein, across a wide range of species, suggest a teleological role in cardiovascular regulation and inflammation. "
03/01/2015 - "Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of UCP2."

04/01/1999 - "TNF-binding protein ameliorates inhibition of skeletal muscle protein synthesis during sepsis."
08/01/2012 - "The purpose of the study was to evaluate the value of heart-type fatty acid-binding protein (hFABP) as a novel clinical biomarker in patients with severe sepsis. "
01/01/2013 - "Here, we investigated the protein-binding rate and elimination efficiency of LZD in a sepsis patient receiving dialysis. "
08/01/2012 - "Usefulness of heart-type fatty acid-binding protein in patients with severe sepsis."
10/01/2010 - "Urinary L-type fatty acid-binding protein showed the higher value of area under the receiver operating characteristic curve for mortality compared with Acute Physiology and Chronic Health Evaluation (APACHE) II and Sepsis-related Organ Failure Assessment (SOFA) scores (L-type fatty acid-binding protein 0.994 [0.956-0.999], APACHE II 0.927 [0.873-0.959], and SOFA 0.813 [0.733-0.873], p < .05). "

07/01/2015 - "In addition, patients with ESRD may also have alterations in gastrointestinal absorption, volume of distribution, protein binding, and metabolic clearance of pharmacologic agents. "
01/01/2011 - "Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease."
12/01/2009 - "Serum level of heart-type Fatty Acid-binding protein in patients with chronic renal failure."
12/01/2008 - "End-stage renal disease (ESRD) is associated with marked alterations in the pharmacokinetics of many drugs, not only from reduction in renal clearance but also from changes in metabolic activity, bioavailability, volume of distribution and plasma protein binding. "
09/01/2001 - "The influence of ESRD on the different phases of the pharmacokinetic profile of drugs in general is examined in light of bioavailability, distribution, protein binding, metabolism, and elimination. "