Peptides

Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

Also Known As:

Networked: 22950 relevant articles (719 outcomes, 2147 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Itoh, Kyogo: 77 articles (10/2015 - 02/2002)
2.	Gallo, Richard L: 47 articles (05/2015 - 09/2002)
3.	Harada, Mamoru: 37 articles (09/2015 - 02/2002)
4.	Hancock, Robert E W: 36 articles (12/2015 - 03/2002)
5.	Chen, Xiaoyuan: 33 articles (10/2015 - 09/2004)
6.	Matsueda, Satoko: 31 articles (10/2015 - 10/2003)
7.	Yamada, Akira: 30 articles (10/2015 - 09/2002)
8.	Sette, Alessandro: 30 articles (05/2015 - 12/2003)
9.	Itoh, K: 30 articles (12/2007 - 03/2000)
10.	Shichijo, Shigeki: 28 articles (10/2015 - 02/2002)

Related Diseases

1.	Neoplasms (Cancer) 12/23/2014 - "This system resulted in highly improved in vitro/in vivo tumor-selective uptake over AuNP bearing a single ligand (Tf or Tat peptides). " 12/25/2009 - "The first class includes peptides that are highly potent against both bacteria and cancer cells, but not against mammalian cells. " 07/01/2012 - "The insertion of peptides into fiber proved more effective for targeting tumor cell types expressing low levels of CAR receptor, as this strategy can partially compensate for the very low infectivity of wild-type adenovirus in those cells. " 01/01/2006 - "To increase the chances for successful therapy it is important to deliver full-length tumor Ag instead of loading single peptides. " 01/01/2006 - "To increase chances for successful therapy it is important to deliver full-length tumor Ag instead of loading single peptides. "
2.	Infection 10/21/2008 - "On the basis of the structural and functional information of anti-HIV peptides from a previous study, we designed an HIV fusion inhibitor named CP32M, a 32-mer synthetic peptide that is highly effective in inhibiting infection by a wide range of primary HIV-1 isolates from multiple genotypes with R5- or dual-tropic (R5X4) phenotype, including a group O virus (BCF02) that is resistant to T20 and C34 (another anti-HIV peptide). " 01/01/2013 - "Besides the native peptides, several shortened, modified, or even artificial sequences were highly effective in different murine infection models. " 07/01/2007 - "Most importantly, CTL lines directed against these peptides conferred protection against lethal WNV infection in direct proportion to the epitope immunodominance. " 03/01/2001 - "Together, hLF and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant S. " 01/25/2015 - "This work demonstrates a design strategy to optimize antimicrobial peptides with an ideal balance of minimal cytotoxicity, enhanced stability, potent cell penetration and effective antimicrobial activity, which hold great promise for the treatment of intracellular microbial infections and potentially systemic anti-infective therapy. "
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2015 - "Taken together with results of others that found brain clearance of Aβ peptides and behavioral improvements mediated by CD36 in mice, regulation of CD36-mediated Aβ phagocytosis by suppression of EP2 signaling may provide a new approach to suppressing some aspects of Alzheimer disease pathogenesis. " 04/18/2003 - "Our results suggest that the pharmacological profile of beta-sheet breaker peptides can be improved to produce compounds with drug-like properties that might offer a new promise in the treatment of Alzheimer's disease." 08/01/2015 - "Moreover, recent studies suggest that the interactions between RAGE and Aβ peptides may be the culprit behind Alzheimer's disease (AD). " 05/01/2012 - "A survey of peptides with effective therapeutic potential in Alzheimer's disease rodent models or in human clinical studies." 01/01/2012 - "The objective of the present study was to clarify the diagnostic impact of the Aβ peptides 1-38ox, 2-40, and 2-42 peptides on the neurochemical cerebrospinal fluid (CSF) diagnosis of Alzheimer's disease (AD). "
4.	Melanoma (Melanoma, Malignant) 08/01/2001 - "There are several reports of successful induction of HLA class I-restricted antitumor CTLs using MAGE peptides, and some clinical trials with these immunogenic peptides were reported as effective for some patients with malignant melanoma. " 09/01/2015 - "Vaccination with Melanoma Helper Peptides Induces Antibody Responses Associated with Improved Overall Survival." 11/30/2001 - "Of major interest, we determined that freshly-isolated PBMC frequencies of Th1-type CD4+ T recognizing these peptides are frequently elevated in HLA-DR4+ melanoma patients (but not normal donors) that are currently disease-free as a result of therapeutic intervention. " 03/01/2004 - "Substitution of the C-terminal anchor residue of the survivin-derived peptides improved the recognition by tumor-infiltrating lymphocytes from melanoma patients. " 02/15/1997 - "One of these peptides was also immunogenic for lymphocytes derived from a melanoma patient in remission. "
5.	Inflammation 01/01/2014 - "A growing amount of evidence suggests that these peptides may also impact the cardiovascular system, including beneficial effects on myocardial cells, lipid profiles and blood pressure as well as reduced markers of systemic inflammation and improved endothelial dysfunction. " 06/17/2015 - "Thus, drugs that promote the clearance of Aβ peptides and resolution of inflammation may represent viable therapeutic approaches. " 01/01/2015 - "In this sense, we have previously shown that next-generation active vaccination technology with short peptides, AFFITOPEs®, was effective in two transgenic models of synucleinopathies at reducing behavioral deficits, α-syn accumulation and inflammation. " 10/30/2011 - "These results suggested that our peptides inhibited MK2 activity in vitro and should be investigated further as a potential therapeutic for applications involving inflammation. " 09/01/2012 - "Regarding autoimmunity, successful data have been reported in numerous mouse models of autoimmune inflammation, yet relatively few clinical trials based on synthetic peptides are currently underway. "

Related Drugs and Biologics

1.	Antigens
2.	Amyloid (Amyloid Fibrils)
3.	Proteins (Proteins, Gene)
4.	Antibodies
5.	Vaccines
6.	Epitopes
7.	Anti-Bacterial Agents (Antibiotics)
8.	Apolipoproteins E (ApoE)
9.	Cytokines
10.	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)

Related Therapies and Procedures

1.	Immunotherapy
2.	Heterologous Transplantation (Xenotransplantation)
3.	Drug Therapy (Chemotherapy)
4.	Transplants (Transplant)
5.	Injections