Lipoproteins (Lipoprotein)

Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.

Also Known As:

Networked: 21930 relevant articles (667 outcomes, 2551 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rader, Daniel J: 60 articles (11/2015 - 01/2002)
2.	Kastelein, John J P: 53 articles (07/2015 - 07/2002)
3.	Watts, Gerald F: 51 articles (12/2015 - 02/2002)
4.	Schaefer, Ernst J: 46 articles (05/2015 - 02/2002)
5.	Ballantyne, Christie M: 42 articles (12/2014 - 03/2002)
6.	Barrett, P Hugh R: 40 articles (12/2015 - 01/2002)
7.	Otvos, James D: 36 articles (08/2015 - 01/2002)
8.	Nordestgaard, Børge G: 34 articles (09/2015 - 10/2002)
9.	Fisher, Edward A: 34 articles (08/2015 - 02/2002)
10.	Yamashita, Shizuya: 33 articles (07/2015 - 09/2002)

Related Diseases

1.	Atherosclerosis 09/01/2005 - "High-density lipoprotein (HDL) plays an important role in protection against atherosclerosis. " 08/01/2014 - "High-density lipoprotein (HDL) confers protection against atherosclerosis by several different mechanisms. " 06/01/2012 - "High-density lipoprotein (HDL) is protective against atherosclerosis development. " 08/01/2009 - "High-density lipoprotein (HDL) and 17beta-estradiol independently provide protection against atherosclerosis. " 08/01/2006 - "In our view, CETP inhibitors in combination with statins will be profoundly beneficial in reducing human atherosclerosis, primarily because they normalize HDL particles and prevent the transfer of cholesteryl ester from HDL to atherogenic lipoproteins."
2.	Hypertriglyceridemia 08/01/2009 - "Hypertriglyceridemia is a consequence of increased VLDL synthesis from the liver, which is also loaded by ectopic triglyceride deposition, reduced clearance of triglyceride-rich lipoproteins or both. " 03/01/2009 - "ApoCIII causes hypertriglyceridemia by inhibiting the catabolism and the clearance of TG-rich lipoproteins (TLRs), and the association of apoCIII with CHD has been commonly attributed to these properties; however, it has been untested whether apoCIII itself or in association with lipoproteins directly affects atherogenic mechanisms in vascular cells. " 05/01/1991 - "One reason for the variability of results obtained with H-1 NMR may be that hypertriglyceridemia also induces linewidth narrowing of lipoprotein lipid methyl and methylene resonances, and can cause false positive results. " 08/27/1984 - "Finally, hepatic overproduction of VLDL can produce hypertriglyceridemia, or if there is a concomitant defect in clearance of lipoproteins, an accentuated increase of VLDL, remnants or LDL will occur. " 05/01/2015 - "In the present study, we examined the association of 13 polymorphisms at these 10 loci with the prevalence of hypertriglyceridemia, hyper-low-density lipoprotein (LDL) cholesterolemia, hypo-high-density lipoprotein (HDL) cholesterolemia, or CKD in community-dwelling Japanese individuals. "
3.	Coronary Disease (Coronary Heart Disease) 06/01/2010 - "High-density lipoprotein (HDL) is believed to be protective against coronary heart disease (CHD). " 01/01/2009 - "Clinical trials demonstrate that to reduce cardiovascular events, a statin is more effective than placebo, intensive statin therapy is more effective than moderate statin therapy in patients with established coronary disease, and in patients receiving intensive statin therapy the lowest risk is associated with the lowest low-density lipoprotein levels. " 08/01/1995 - "The protective effects of alcohol against coronary heart disease may be partly mediated by these lipoprotein changes. " 01/01/1985 - "Although the consequences of these changes and their mechanisms remain to be established, they may explain the negative outcome of the prevention trials, the protection against coronary disease offered by the reduction of blood pressure being offset by the associated changes in lipoprotein metabolism." 02/01/1995 - "Although these observations are limited to a single phase of the menstrual cycle, the alcohol-induced changes in lipoproteins are consistent with changes that are thought to confer protection against coronary heart disease."
4.	Hyperlipidemias (Hyperlipidemia) 11/01/1998 - "The TG responses in plasma and TG-rich-lipoprotein (TRL) (d <1.006) after the oral fat load were significantly greater in NIDDMs with nephropathy compared to controls or NIDDMs without nephropathy, while such a marked postprandial lipemia was not observed in patients with primary renal disease. " 11/01/2000 - "We attempted to determine the effectiveness of exercise prescription for women with hyperlipidemia (HL), because some HL women showed no significant improvement in serum lipid and lipoprotein profiles despite the continuation of exercise conditioning. " 01/01/2013 - "Depending on study aims, for the use of the model it may be beneficial to perform single-dose assessments at time points later than 36 h when the lipoprotein concentrations will be more similar to those seen in patient with hyperlipidemia." 02/01/2006 - "A combination of preparative and analytical ultracentrifugation was used to investigate of LDL aliquots, to prepare radioactive-labeled lipoproteins and to study induced hyperlipidemia in rabbits. " 02/01/2006 - "The objective of this study was to investigate the lipoprotein profiles in Wistar rats and New Zealand white rabbits with experimentally induced hyperlipidemia by means of ultracentrifugation. "
5.	Coronary Artery Disease (Coronary Atherosclerosis) 04/01/1993 - "Disorders associated with the overproduction or delayed clearance of beta-very low density lipoprotein and low density lipoprotein (LDL) are strikingly related to premature coronary artery disease. " 04/01/2013 - "High-density lipoprotein (HDL) particles are heterogeneous in their composition, structure and size and may differ in conferring protection against coronary artery disease. " 07/01/2000 - "Its high density lipoprotein-lowering effect, however, prevents it from being protective against progression of coronary atherosclerosis. " 04/01/2000 - "Protection against coronary artery disease (CAD) by moderate alcohol consumption is thought to be partly mediated through an increase in high density lipoprotein (HDL) levels. " 10/01/1995 - "Epidemiological evidence suggests that plasma high-density lipoprotein (HDL) is protective against coronary artery disease, whereas oxidatively modified low density lipoprotein is atherogenic. "

Related Drugs and Biologics

1.	Cholesterol
2.	LDL Cholesterol
3.	HDL Cholesterol
4.	Lipoproteins (Lipoprotein)
5.	Triglycerides (Triacylglycerol)
6.	Insulin (Novolin)
7.	Lipids
8.	Apolipoproteins
9.	Apolipoprotein A-I (Apolipoprotein A1)
10.	Apolipoproteins B (ApoB)

Related Therapies and Procedures

1.	Blood Component Removal (Apheresis)
2.	Drug Therapy (Chemotherapy)
3.	Renal Dialysis (Hemodialysis)
4.	Plasmapheresis
5.	Transplants (Transplant)