Globulins

A group of proteins that are salt-soluble and form a large fraction of BLOOD PROTEINS. There are three types of globulins, ALPHA-GLOBULINS, BETA-GLOBULINS, and GAMMA-GLOBULINS, which are distinguished from one another by their degree of electrophoretic mobility.

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Networked: 3062 relevant articles (108 outcomes, 272 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nigro, Giovanni: 12 articles (10/2022 - 09/2005)
2.	Mori, Keiichiro: 11 articles (03/2022 - 01/2020)
3.	Shariat, Shahrokh F: 10 articles (03/2022 - 01/2020)
4.	Karakiewicz, Pierre I: 9 articles (03/2022 - 08/2020)
5.	Mostafaei, Hadi: 9 articles (03/2022 - 01/2020)
6.	Quhal, Fahad: 9 articles (03/2022 - 08/2020)
7.	Laukhtina, Ekaterina: 8 articles (03/2022 - 01/2021)
8.	Pradere, Benjamin: 8 articles (03/2022 - 01/2021)
9.	Schuettfort, Victor M: 8 articles (03/2022 - 01/2021)
10.	Adler, Stuart P: 8 articles (12/2020 - 09/2005)

Related Diseases

1.	Infections 07/01/1982 - "In contrast, a combination of a subneutralizing dilution of globulin and leukocytes from nonimmune or immune human donors, given one day before inoculation, was highly protective against lethal HSV infection. " 01/01/2017 - "Addition of rabbit antihuman thymocyte globulin to αCD154 (n = 6) or αCD154 + αCD20 (n = 10) improved graft protection from graft rejection and failure during treatment but was associated with significant morbidity in 8 of 16 recipients (6 infections, 2 drug-related complications). " 12/01/2016 - "A recent randomized controlled trial of treatment of CMV during pregnancy with hyperimmune globulin did not show significant efficacy in prevention of foetal infection and morbidity, although there was a trend towards improvement with treatment. " 02/01/1977 - "Increasing doses of anti-lymphoblast globulin (ALG) had beneficial results in HL-A mismatched sibling transplants, but were slightly detrimental in phenotypically identical HL-A donor-recipient pairs because of an increased rate of infection. " 12/01/2009 - "Experiments using animal models of CMV infection and observational studies in humans indicate that administration of a CMV hyperimmune globulin (HIG) to the pregnant woman with a primary CMV infection should be effective for both the treatment and prevention of fetal infection. "
2.	Body Weight (Weight, Body) 01/01/2015 - "The data revealed that the g.34490C > T mutation in intron 3 was significantly associated with liver weight and globulin, the g.35363T > C polymorphism in exon 5 was significantly associated with body weights at 6, 10, and 12 weeks of age. " 11/01/2011 - "Heifers with serum γ-globulin levels >10 g/L at 30 to 60 h of life showed better health status and reached body weights allowing first insemination sooner." 09/01/1974 - "At 16 and 18 days the ability of the middle region had declined significantly, and this decline continued so that little globulin was transmitted from this region at 20 and 22 days.3. The proximal intestine retained the ability to transmit globulin to the circulation in significant amounts up to 20 days.4. There is a close negative correlation between body weight and total radioactivity of the sera of rats which had received doses of labelled globulin into the proximal and middle regions of the intestine. " 01/01/2021 - "In this multicenter, double-blind trial, pregnant women with primary CMV infection diagnosed before 24 weeks' gestation were randomly assigned to receive a monthly infusion of CMV hyperimmune globulin (at a dose of 100 mg per kilogram of body weight) or matching placebo until delivery. " 09/01/2023 - "Markers of treatment success included resolution of pyrexia, effusions, and presenting signs of FIP in the first half of treatment and normalization of globulin concentration, and continued body weight gains in the latter half of the treatment period. "
3.	Aplastic Anemia (Anemia, Hypoplastic) 01/01/1984 - "A controlled prospective trial of antithoracic duct lymphocyte globulin (ATDLG) for treatment of severe aplastic anemia." 01/01/2020 - "Treatment of Severe Aplastic Anemia with Porcine Anti-Human Lymphocyte Globulin." 10/14/2016 - "[Progress in the treatment of severe aplastic anemia with porcine anti- human lymphocyte globulin]." 04/01/2009 - "Treatment of severe aplastic anemia by immunosuppressor anti-lymphocyte globulin/anti-thymus globulin as the chief medicine in combination with Chinese drugs." 07/01/2003 - "Direct binding of antithymoctye globulin to haemopoietic progenitor cells in aplastic anaemia."
4.	Cytomegalovirus Infections (Inclusion Disease) 09/29/2005 - "Treatment of pregnant women with CMV-specific hyperimmune globulin is safe, and the findings of this nonrandomized study suggest that it may be effective in the treatment and prevention of congenital CMV infection. " 01/01/2019 - "The Congenital Human Cytomegalovirus Infection Prevention (CHIP) study, a randomized, blinded, placebo-controlled trial, demonstrated that the efficacy of hyperimmune globulin (HIG) was not different from that of placebo regarding transmission of cytomegalovirus (CMV) from mothers to newborns. " 11/09/2023 - "Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection - 2-Year Outcomes." 01/01/2022 - "Secondary analysis of a multicenter randomized placebo-controlled trial designed to evaluate whether cytomegalovirus hyperimmune globulin reduces congenital cytomegalovirus infection in neonates of individuals diagnosed with primary cytomegalovirus infection before 24 weeks of gestation. " 01/01/2021 - "A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection."
5.	Hepatitis 02/01/1975 - "In addition, it was found that American globulin is comparable to Israeli globulin for protection against strains of Type A hepatitis prevalent in Israel. " 09/01/1986 - "Hepatitis hyperimmune globulin and exposure to human immunodeficiency virus." 10/28/1983 - "The hospital's hepatitis control program costs $91,995 per year, including costs for workman's compensation, hyperimmune globulin, laboratory tests, lost revenue, liability, personnel, and medical treatment. " 11/01/1976 - "This globulin was prepared selectively from plasma of donors giving a history of overt viral hepatitis two or more years earlier. " 11/20/1975 - "Among 251 persons passively immunized with globulin having a conventionally low anti-HBs titer, hepatitis developed in 17 (seven per cent) within six months. "

Related Drugs and Biologics

1.	Albumins
2.	Proteins (Proteins, Gene)
3.	Thomsen-Friedenreich antibodies
4.	Cyclosporine (Ciclosporin)
5.	Ganciclovir (Cytovene)
6.	Immunoglobulin G (IgG)
7.	Creatinine
8.	Testosterone (Sustanon)
9.	Hemoglobins (Hemoglobin)
10.	Alanine Transaminase (SGPT)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Splenectomy
4.	Transplantation
5.	Stem Cell Transplantation