Cytoskeletal Proteins

Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.

Also Known As:

Networked: 557 relevant articles (7 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pant, Harish C: 4 articles (11/2010 - 06/2006)
2.	Towbin, Jeffrey A: 3 articles (08/2015 - 03/2002)
3.	Miyagawa, Shigeru: 3 articles (12/2013 - 08/2005)
4.	Sawa, Yoshiki: 3 articles (12/2013 - 08/2005)
5.	Vatta, Matteo: 3 articles (10/2010 - 03/2002)
6.	Haverkamp, Wilhelm: 2 articles (10/2015 - 12/2002)
7.	Chen, Ju: 2 articles (10/2015 - 02/2009)
8.	Zhang, Y: 2 articles (03/2015 - 05/2003)
9.	Chen, Lin: 2 articles (01/2015 - 04/2010)
10.	Zhou, Jie: 2 articles (10/2014 - 04/2011)

Related Diseases

1.	Fibrosis (Cirrhosis) 02/01/2006 - "Sheet-shaped myoblast graft implantation improved cardiac performance and prolonged life expectancy, associated with a reduction in myocardial fibrosis and re-organization of the cytoskeletal proteins in DCM hamsters. " 05/01/2012 - "Left ventricular (LV) in vivo function, myocardial fibrosis, cytoskeletal proteins expression and distribution, Ca(2+) handling and contractile function of isolated cardiomyocytes were evaluated at the stages of the early, compensated, and late, decompensated heart failure in 4-, 12- and 14-month-old Tgαq*44 mice, respectively, and compared to age-matched wild-type FVB mice. " 12/01/2013 - "ONO1301 atelocollagen-sheet implantation reorganized cytoskeletal proteins, such as α-sarcoglycan, increased capillaries, reduced fibrosis, and was associated with upregulated expression of multiple cardioprotective factors, leading to preservation of cardiac performance and prolongation of survival in the δ-sarcoglycan-deficient DCM hamster." 08/01/2005 - "An improved survival associated with transient reorganization of the cytoskeletal proteins and reduction in myocardial fibrosis was achieved by hepatocyte growth factor treatment in an adult hamster model of dilated cardiomyopathy. " 07/01/2015 - "The pathoproteomic signature of the mdx-4cv diaphragm included a significant increase in the fibrosis marker collagen and related extracellular matrix proteins (asporin, decorin, dermatopontin, prolargin) and cytoskeletal proteins (desmin, filamin, obscurin, plectin, spectrin, tubulin, vimentin, vinculin), as well as decreases in proteins of ion homeostasis (parvalbumin) and the contractile apparatus (myosin-binding protein). "
2.	Neoplasms (Cancer) 01/01/2016 - "Use of Nanobodies to Localize Endogenous Cytoskeletal Proteins and to Determine Their Contribution to Cancer Cell Invasion by Using an ECM Degradation Assay." 09/01/2015 - "Thus, canine skeletal OS is composed of pleomorphic and heterogenous tumor cells as is reflected in the diversity of histologic patterns and expression of cytoskeletal proteins. " 04/13/2015 - "Biomechanical behaviours of cells change during cancer progression due to alterations in the main cytoskeletal proteins. " 10/17/2014 - "The results show that the PriSM selectively accumulate in cancer cells via macropinocytosis to impede the dynamics of cytoskeletal filaments via promiscuous interactions with cytoskeletal proteins, thus inducing apoptosis. " 06/01/2014 - "Quantitative pattern analysis of cells has wide applications for understanding mechanisms of small molecules, because many anti-cancer drugs directly or indirectly target cytoskeletal proteins. "
3.	Infection 01/01/2012 - "Many RBC disorders result from mutations in genes encoding cytoskeletal proteins and these are associated with increased protection against malarial infections. " 07/01/2014 - "However, the importance of PIP2 in regulating cytoskeletal proteins and thus HIV-1 infection has been overlooked. " 01/01/2014 - "In addition to preventing macrophage infection, CCR5 antagonists could diminish viral-induced alteration and phosphorylation of cytoskeletal proteins, monocyte adhesion to the brain endothelium and viral entry into the central nervous system." 06/01/2011 - "GBS-III-COH31 in a time- and infection ratio-dependent manner induces great macrophage cytoskeleton alterations, causing degradation of several structural and regulatory cytoskeletal proteins. " 01/01/2010 - "These results provided a basis for the further analysis of ECTV motion in the infected cells as well as for impact of ECTV infection on the cytoskeletal proteins."
4.	Neoplasm Metastasis (Metastasis) 12/15/2014 - "Therapeutic agents that target cytoskeletal proteins and are effective in inhibiting cell migration may open new avenues in the treatment of cancer and metastasis. " 05/01/2008 - "Hence, S100A4 interacts with cytoskeletal proteins and enhances metastasis of several types of cancer cells. " 06/01/2015 - "The intracellular domain of Trask has the ability to undergo tyrosine phosphorylation and thereafter undergo increased genomic expression, as well as interact with cytoskeletal proteins in the cell periphery and other local signal transduction machinery to induce invadopodia formation and distant metastasis. " 05/01/2010 - "fascin has received a lot of attention among cytoskeletal proteins because multiple clinical studies have implicated its expression in cancer progression and metastasis. " 01/01/2015 - "Despite efforts to discover the cellular pathways regulating breast cancer metastasis, little is known as to how prolactin (PRL) cooperates with extracellular environment and cytoskeletal proteins to regulate breast cancer cell motility and invasion. "
5.	Muscular Diseases (Myopathy) 02/01/1999 - "Immunohistochemical study of some cytoskeletal proteins in hereditary myopathy of the diaphragmatic muscles in Holstein-Friesian cattle." 05/01/1999 - "Changes in the cytoskeletal proteins, sarcoplasmic reticulum, and capillaries in acute relaxant-steroid myopathy (ARSM) in contrast to the corticosteroid myopathy." 12/01/2001 - "Our results suggest that ECP functions in the degradation of myofibrillar and membrane-associated cytoskeletal proteins, indicating that tissue eosinophils have a specific role in muscle fiber degradation in some myopathies associated with numerous tissue eosinophils, such as eosinophilic myositis, eosinophilic myalgia syndrome, and eosinophilic endocardial disease." 10/01/2002 - "Finally, direct imaging of muscle cells with fluorescently labeled cytoskeletal proteins shows that lack of the desmin protein results in tremendous disorganization of the myofibrillar lattice which may help to explain desmin myopathies." 10/01/2007 - "Myotilinopathy is a subgroup of myofibrillar myopathies caused by mutations in the myotilin gene in which there is aggregation of abnormal cytoskeletal proteins and ubiquitin. "

Related Drugs and Biologics

1.	Vimentin
2.	Tubulin
3.	Desmin
4.	Retinaldehyde (Retinal)
5.	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
6.	Proteins (Proteins, Gene)
7.	Antibodies
8.	Neurotransmitter Agents (Neurotransmitter)
9.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
10.	Antigens

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Lenses
4.	Axotomy
5.	Liver Transplantation