Intercellular Signaling Peptides and Proteins (Growth Factors)

Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.

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Networked: 12097 relevant articles (294 outcomes, 1091 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Morishita, Ryuichi: 18 articles (01/2014 - 05/2002)
2.	Anitua, Eduardo: 15 articles (10/2015 - 02/2007)
3.	Orive, Gorka: 14 articles (10/2015 - 02/2008)
4.	Achen, Marc G: 14 articles (01/2014 - 07/2002)
5.	Stacker, Steven A: 13 articles (06/2013 - 07/2002)
6.	Lyman, Gary H: 12 articles (10/2013 - 11/2003)
7.	Meldrum, Daniel R: 12 articles (08/2011 - 06/2004)
8.	Yarden, Yosef: 11 articles (03/2015 - 02/2003)
9.	Konturek, S J: 11 articles (09/2006 - 12/2000)
10.	Petraglia, Felice: 10 articles (12/2015 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2007 - "Recent excitement has been generated by the clinical efficacy of targeted antiangiogenic therapy against growth factors important in angiogenesis and tumor proliferation. " 07/01/2009 - "Since angiogenesis is crucial for tumor growth, a better understanding of the potential clinical relevance as well as the interactions between the numerous proangiogenic growth factors is essential to develop improved therapeutic strategies in these tumors. " 01/01/2009 - "Advances in neutrophil biology coupled with better understanding and development of myeloid growth factors offer great promise for improving the care of patients with cancer and many other disorders." 01/01/2008 - "growth factors and their receptors), it was hoped that new targeted agents, by inhibiting cancer-specific pathways, would spare normal cells and thereby offer improved safety benefits and a higher therapeutic index over standard chemotherapeutics. " 06/01/1990 - "In the field of cancer therapy the major benefit of the haemopoietic growth factors will be if they permit dosage escalation and there is a consequent improvement in response rate and long-term survival. "
2.	Wounds and Injuries (Trauma) 08/01/1993 - "Growth factors are extremely potent biologic agents that show promise in accelerating wound repair in both animal and human studies. " 01/01/2010 - "However, the exogenous application of growth factors to chronic wounds has not proven to be effective in healing them. " 09/24/2008 - "Growth factors are known to act in concert to promote wound repair, but their topical application rarely leads to a significant clinical improvement of chronic wounds due to premature inactivation in wound environment. " 06/01/1990 - "The animals treated with growth factors also had significantly greater wound closure at 21 days than those treated with the vehicle. " 04/01/2011 - "These results suggest that simple uniform distributions of growth factors immobilized to an extracellular matrix material may be as effective in directing cell migration into a wound site as more complex patterns with concentration gradients."
3.	Neutropenia 11/01/1999 - "Hematopoietic growth factors accelerate the recovery from treatment-induced neutropenia and may improve the remission rate, remission duration, and even overall survival. " 11/01/1988 - "Early studies in animals and in humans suggest that these cell growth factors are effective in correcting neutropenia." 08/01/1995 - "There is increasing evidence that haemopoietic growth factors are effective in reversal of neutropenia associated with large granular lymphocytes (LGLs) proliferation. " 05/01/2013 - "During the 1990 s he was one of the first in Europe who have used hematopoietic growth factors as a supportive therapy in the protocol ALL-BFM and has also helped to set up the International Registry for Severe Chronic Neutropenias [SCNIR] in his Department. " 01/01/1998 - "Grade 3 and 4 neutropenia occurred, respectively in 30% and 23% of the cycles; 6% of the cycles benefited from medullary growth factors. "
4.	Infection 09/01/1997 - "Such changes in growth factors could be important in a variety of processes that occur during infection, such as protection against injury or tissue repair and recovery processes." 01/01/1993 - "We conclude that myeloid growth factors are effective for the treatment and prevention of acute infections and chronic inflammatory complications in patients with GSD Ib." 05/01/2012 - "The Bim-dependent intrinsic pathway of apoptosis removes effector CD8 T cells upon clearance of viral infection, which is driven by withdrawal of growth factors. " 01/01/2011 - "Evidence from ALL trials is mixed with some studies suggesting a reduction of severe infections by myeloid growth factors whereas others report no effect. " 05/15/2007 - "This study investigates whether dose modifications for adverse hematologic effects or the use of hematopoietic growth factors influenced the outcome of therapy for hepatitis C virus (HCV) infection in patients who were coinfected with HCV and human immunodeficiency virus (HIV) and who were participants in a randomized, controlled trial. "
5.	Ulcer 12/01/1993 - "Several growth factors are showing promising results in clinical trials, especially in cases of impaired healing, such as chronic ulcers. " 11/01/2007 - "This study tests the hypothesis that addition of a protease-modulating matrix enhances the efficacy of autologous growth factors in diabetic ulcers. " 12/01/1997 - "Furthermore, we believe that in some patients ulcer healing may be improved by exogenous provision of specific growth factors." 06/15/2001 - "In particular, the ulcer-healing model using the cultured monolayer is promising and convenient for the study of several growth factors such as HGF as well as antiulcerogenic agents. " 03/01/2000 - "Growth factors in ulcer healing: lessons from recent studies."

Related Drugs and Biologics

1.	Cytokines
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Epidermal Growth Factor (EGF)
4.	Hormones
5.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
6.	Granulocyte Colony-Stimulating Factor (G-CSF)
7.	Insulin (Novolin)
8.	Insulin-Like Growth Factor I (IGF-1)
9.	Proteins (Proteins, Gene)
10.	Collagen

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplants (Transplant)
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Tissue Therapy (Cell Therapy)
5.	Injections