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DNA-Binding Proteins (DNA Binding Protein)

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Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Also Known As:

DNA Binding Protein; Single-Stranded DNA-Binding Protein; Single Stranded DNA Binding Proteins; DNA Single-Stranded Binding Protein; SS DNA BP; Binding Protein, DNA; DNA Binding Proteins; DNA Single Stranded Binding Protein; DNA-Binding Protein, Single-Stranded; Single Stranded DNA Binding Protein; DNA Helix Destabilizing Proteins; Single-Stranded DNA Binding Proteins

Networked: 1111 relevant articles (5 outcomes, 54 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - DNA-Binding Proteins: 1111

Experts

1.	Trojanowski, John Q: 46 articles (12/2015 - 07/2007)
2.	Dickson, Dennis W: 30 articles (11/2015 - 05/2007)
3.	Lee, Virginia M-Y: 27 articles (12/2015 - 07/2007)
4.	Rademakers, Rosa: 26 articles (07/2015 - 10/2007)
5.	Hasegawa, Masato: 21 articles (08/2014 - 12/2006)
6.	Neumann, Manuela: 20 articles (07/2015 - 02/2007)
7.	Arai, Tetsuaki: 20 articles (08/2014 - 12/2006)
8.	Van Broeckhoven, Christine: 18 articles (02/2015 - 08/2009)
9.	Akiyama, Haruhiko: 17 articles (08/2014 - 12/2006)
10.	Miller, Bruce L: 16 articles (06/2015 - 06/2008)

Related Diseases

1.	Frontotemporal Lobar Degeneration (Semantic Dementia) 03/01/2014 - "In cohort 2, the frequency of carriers homozygous for the minor allele was not significantly reduced in patients as compared to controls (OR 0.77, p = 0.079); however, a significant reduction was observed when focusing on those patients with frontotemporal lobar degeneration and TAR DNA-binding protein 43 inclusions (FTLD-TDP; OR 0.26, p < 0.001). " 06/01/2013 - "Laminar distribution of the pathological changes in sporadic frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) proteinopathy: a quantitative study using polynomial curve fitting." 07/26/2011 - "The aim of this study was to compare clinical features and perfusion patterns on SPECT of patients with familial FTLD-TAR DNA binding protein 43 kDa (TDP) and MAPT mutations. " 02/01/2010 - "Studies suggest that frontotemporal lobar degeneration with transactive response DNA-binding protein of 43 kDa (TDP-43) proteinopathy (FTLD-TDP) is heterogeneous with division into four or five subtypes. " 01/01/2009 - "Recent studies showed that TAR DNA-binding protein 43 (TDP-43), encoded by the TARDBP gene, is a major pathological protein in both sporadic and familial frontotemporal lobar degeneration (FTLD). "
2.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/01/2015 - "We have used this technique to study aspects of amyotrophic lateral sclerosis (ALS) by administering AAV encoding the ALS-related gene transactive response DNA binding protein of 43 kDa (TDP-43) to neonatal rats. " 05/01/2014 - "The aim of this study was to investigate whether an increased level of TAR DNA-binding protein 43 (TDP-43) in the cerebrospinal fluid (CSF) could be a biomarker for amyotrophic lateral sclerosis (ALS) and facilitate differential diagnosis of ALS from peripheral motor neuropathy. " 04/01/2009 - "Recent studies identified rare missense mutations in amyotrophic lateral sclerosis (ALS) patients in the TARDBP gene encoding TAR DNA binding protein (TDP)-43, the major protein of the ubiquitinated inclusions (UBIs) found in affected motor neurons (MNs). " 11/23/2015 - "Transactive response DNA-binding protein 43 kD (TDP-43) is an aggregation-prone prion-like domain-containing protein and component of pathological intracellular aggregates found in most amyotrophic lateral sclerosis (ALS) patients. " 08/01/2015 - "Review: Prion-like mechanisms of transactive response DNA binding protein of 43 kDa (TDP-43) in amyotrophic lateral sclerosis (ALS)."
3.	Infection 10/01/2014 - "Early in infection, UL84FLAG colocalized with the viral single-stranded DNA binding protein UL57, but colocalization became less prominent as infection progressed. " 01/01/2014 - "[Application of artificial DNA-binding proteins and artificial nucleases to prevention of virus infection: development of virus-resistant plants and protein-based anti-viral drugs]." 02/01/2012 - "The protamine-like DNA-binding protein P6.9 epigenetically up-regulates Autographa californica multiple nucleopolyhedrovirus gene transcription in the late infection phase." 01/01/2010 - "EBNA1 is an EBV-encoded DNA-binding protein required for viral genome maintenance during latent infection. " 05/01/2008 - "The ability of Vpx to counteract the restriction to HIV-1 and SIV infection was dependent upon the HIV-1 Vpr interacting protein, damaged DNA binding protein 1 (DDB1), and DDB1 partially substituted for Vpx when fused to Vpr. "
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 04/01/2014 - "Accumulation of transactive response DNA binding protein (TDP-43) fragments in motor neurons is a post mortem hallmark of different neurodegenerative diseases. " 01/14/2011 - "TAR DNA-binding protein 43 (TDP-43) is associated with a spectrum of neurodegenerative diseases. " 04/01/2010 - "TAR DNA-binding protein 43 in neurodegenerative disease." 01/01/2010 - "The role of the 43-kDa transactivation-responsive DNA-binding protein (TDP43) in neurodegenerative diseases is not yet clearly established. " 09/15/2015 - "TAR DNA-binding protein 43 (TDP-43) is a major disease protein in amyotrophic lateral sclerosis (ALS) and related neurodegenerative diseases. "
5.	Paralysis (Palsy) 01/01/2015 - "This study demonstrates that human UPF1 exerts protective effects in a rat paralysis model based on the amyotrophic lateral sclerosis (ALS)-associated protein, TDP-43 (transactive response DNA-binding protein 43 kDa). " 09/01/2011 - "Recent transgenic mouse studies have revealed a high degree of toxicity due to transactive response DNA-binding protein 43 proteins when overexpressed under the control of strong neuronal gene promoters, resulting in early paralysis and death, but without the presence of amyotrophic lateral sclerosis-like ubiquitinated transactive response DNA-binding protein 43-positive inclusions. "

Related Drugs and Biologics

1.	protein TDP-43 (TDP-43)
2.	DNA (Deoxyribonucleic Acid)
3.	Thrombomodulin
4.	lenalidomide (CC 5013)
5.	Proteins (Proteins, Gene)
6.	Ubiquitin
7.	HMGB1 Protein (HMG1)
8.	tau Proteins (tau Protein)
9.	Histones (Histone)
10.	Viral DNA

Related Therapies and Procedures

1.	Therapeutics
2.	Heterologous Transplantation (Xenotransplantation)