LIM Domain Proteins

A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Al-Hasani, Jaafar: 1 article (01/2021)
2.	Ghosh, Subhajit: 1 article (01/2021)
3.	Hecker, Markus: 1 article (01/2021)
4.	Sporkova, Alexandra: 1 article (01/2021)
5.	Cheng, Zhiheng: 1 article (01/2019)
6.	Cui, Longzhen: 1 article (01/2019)
7.	Dai, Yifeng: 1 article (01/2019)
8.	Fu, Lin: 1 article (01/2019)
9.	Hu, Kai: 1 article (01/2019)
10.	Liu, Yan: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2012 - "Finally, the role of LIM-domain proteins in myofibroblasts found in fibrotic foci and tumor stroma will be discussed." 01/01/2006 - "LIM domain proteins were demonstrated to play key roles in various biological processes such as embryonic development, cell lineage determination, and cancer differentiation. " 07/20/2022 - "BACKGROUND LIM domain proteins play crucial roles in tumors by interacting with diverse proteins. " 02/01/2013 - "LIM-domain proteins are a large family of proteins that are emerging as key molecules in a wide variety of human cancers. "
2.	Carcinogenesis 01/01/2019 - "PDZ and LIM domain proteins (PDLIM) are involved in the regulation of a variety of biological processes, including cytoskeletal organization, cell differentiation, organ development, neural signaling or tumorigenesis. " 04/01/1999 - "The features of the LMO family of genes, which encode LIM-domain proteins involved in T-cell acute leukemia through chromosomal translocations, typify these abnormal functions in tumorigenesis. "
3.	Ganglion Cysts (Ganglion) 06/01/2014 - "The well-represented classes included biomarkers of enteric ganglions, extracellular matrix proteins, LIM domain proteins, serum proteins, and other pleiotropic proteins. "
4.	Genetic Translocation (Chromosomal Translocation) 04/01/1999 - "The features of the LMO family of genes, which encode LIM-domain proteins involved in T-cell acute leukemia through chromosomal translocations, typify these abnormal functions in tumorigenesis. "
5.	Lipoma (Lipomata) 01/01/2021 - "In terms of homology and structural features, lipoma preferred partner is the nearest relative of zyxin among the LIM domain proteins. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Zyxin
3.	Extracellular Matrix Proteins
4.	Biomarkers (Surrogate Marker)
5.	Blood Proteins (Serum Proteins)