Viral Proteins

03/01/2015 - "Therefore, why the same potent host immune responses generated during lytic infection to these viral gene products are not recognized during latency, thereby allowing clearance of latently infected cells, is far from clear. "
09/01/2008 - "While humoral antibody plays a major role in protection against disease, T-cell immunity targeted to viral proteins appears to terminate viral infection. "
01/13/2014 - "Using viral genes to confer pathogen-derived resistance against crops is a well-established procedure, and the expression of various viral gene products has proved to be effective in preventing or reducing infection by various plant viruses since the 1990s. "
07/01/2007 - "These results indicate that the introduction of long dsRNAs corresponding to viral proteins, which are essential for WSSV infection, is quite effective in blocking WSSV infection in P. "
08/13/2013 - "Experimental and computational evidence suggests that HLAs preferentially bind conserved regions of viral proteins, a concept we term "targeting efficiency," and that this preference may provide improved clearance of infection in several viral systems. "

09/15/2008 - "Therefore, Ab to conserved, internal viral proteins, such as NP, provides an unexpected, yet important mechanism of protection against influenza. "
01/01/2014 - "In this study, we performed a computational search, based on a ribosome scanning mechanism, on all influenza A coding sequences to identify possible forward-reading ORFs that could be translated into novel viral proteins. "
10/01/1983 - "Studies on heterotypic interference between influenza A and B viruses: a differential inhibition of the synthesis of viral proteins and RNAs."
06/15/2015 - "Growing resistance to therapies that target viral proteins has led to increased urgency in the search for novel anti-influenza compounds. "
01/01/2015 - "By contrast, memory CD4 T cells recognize conserved viral proteins and are cross-reactive to multiple influenza strains. "

07/01/2014 - "Also involved in tumor progression is the dysregulation of cellular processes by viral proteins, and we describe how this has been investigated by studies in cell culture and in experimental animals and by molecular cellular approaches. "
01/01/2012 - "Current studies of CSC could provide novel insights regarding tumor initiation and progression, their relation with viral proteins and interplay with the tumor micro-environment. "
04/01/2015 - "In addition, some findings provide novel evidence that Polygonatum species may contain potential anti-tumor and anti-viral proteins for possible medical application and large-scale pharmaceutical production. "
01/01/2015 - "Tumor suppressor p53 plays a crucial antiviral role and targeting of p53 by viral proteins is a common mechanism involved in virus oncogenesis. "
12/01/2014 - "In most, if not all, cancers lacking mutation, wild-type (WT) p53 is inactivated by interaction with cellular (MDM2/MDM4) or viral proteins, leading to its degradation. "

09/24/1986 - "These procedures permit efficient and reproducible screening of both endogenous and exogenous (viral) gene products, thus facilitating the study of normal differentiation, the localization of virus and the monitoring of viral diseases. "
04/01/2014 - "Viral proteins have enabled the design of selective and efficacious treatments for viral diseases. "
01/01/2011 - "Detection of viral proteins in combination with viral transcripts is a potentially powerful method for establishing virus-disease relationships."
09/01/2009 - "It was interesting whether Abs from patients with viral diseases can hydrolyze viral proteins. "
07/20/2001 - "The highest homologies were detected between putative viral gene products of CIV and lymphocystis disease virus of fish (LCDV). "

06/01/2003 - "Liver damage caused by chronic hepatitis B virus (HBV) infection may be enhanced through the selection of deleted HBV preS mutants by intracellular accumulation of viral proteins and subsequent cell death. "
10/01/1993 - "These results suggest that increases in viral replication and accumulation of viral proteins in the serum and intracellularly and the subsequent immune response play an important role in initiating acute exacerbations of liver injury in chronic hepatitis B infection. "
05/01/2010 - "Some studies suggested that viral proteins interfere with DNA methyltransferase in chronic hepatitis B. "
11/10/2012 - "This preclinical study investigated the therapeutic efficacy of electroporation (EP)-based delivery of plasmid DNA (pDNA) encoding viral proteins (envelope, core) and IFN-γ in the duck model of chronic hepatitis B virus (DHBV) infection. "