Proteome

01/01/2012 - "With the advances in modern diagnostic expertise for cancer, certain approaches allowing scanning of the complete genome and the proteome are becoming very useful for researchers. "
03/01/2011 - "The improved understanding of the underlying molecular features of common cancers and the availability of a multitude of recently developed technologies to interrogate the genome, transcriptome, proteome and metabolome of tumors and biological fluids have made it possible to develop clinically applicable and cost-effective tests for many common cancers. "
08/01/2007 - "Cancer research in recent years has immensely benefited from the development of novel technologies that enable scientists to perform detailed investigations of genomes, transcriptomes, proteomes, and metabolomes. "
11/01/2020 - "Analysis of ccRCC patient data from The Cancer Proteome Atlas database showed YB-1 expression was negatively associated with survival, whereas SCD1 was associated with improved survival. "
01/01/2018 - "The ultimate goal is to map the entire human cancer proteome to disclose tumor biology and drive improved diagnostics, treatment and management of cancer. "

01/01/2019 - "ECH_0660 gene mutation, causing the pathogen's rapid clearance and offering protection against wild type infection challenge in a vertebrate host, had a minimal impact on proteome similar to our prior observations from transcriptome analysis. "
12/13/2018 - "Complementary to the changes in the proteome, sublethal exposure to NO and H2O2 improved the survival of the bacteria after macrophage infection. "
10/04/2016 - "gondii infection relies on an improved understanding of the proteome and chemical pathways of this parasite. "
07/09/2009 - "Immunization with inflammatory proteome of Brugia malayi adult worm induces a Th1/Th2-immune response and confers protection against the filarial infection."
08/18/2023 - "We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response to infection. "

01/01/2023 - "These findings demonstrate the remarkable efficacy of PCB in alleviating the nociception and inflammation in the AIA mice model and shed new light on mechanisms underlying the PCB modulation of the neuronal proteome. "
06/01/2023 - "This study proposes discriminant milk and plasma proteomes, depending on diet-induced divergence in milk fat secretion, that are related to nutrient homeostasis, inflammation, immunity and lipid metabolism. "
06/01/2023 - "This study showed that the tear proteome in patients with MS is modified and can reflect inflammation. "
01/01/2023 - "Finally, mechanistic studies using transcriptome and proteome analyses suggest inhibition of HDM-induced genes involved in inflammation, cell proliferation, and tissue remodeling by SF-3-030. "
01/01/2023 - "This study identified key molecular and immunological relationships with cervicovaginal inflammation, including higher APCs, bacterial metabolism, and proteome alterations that underlie inflammation. "

01/01/2021 - "One of the key characteristics of senescent cells is a complex secretory phenotype, known as the senescence-associated secretory proteome (SASP), which by prompting immune-mediated clearance of senescent cells maintains tissue homeostasis and suppresses tumorigenesis. "
07/08/2022 - "The aim of the present study was to gain new insights into the progression of prostate carcinogenesis by analyzing the urine proteome. "
01/01/2022 - "Overall, this study provides a comprehensive landscape of the proteome and phosphoproteome of IMPC, which will contribute to a further understanding of IMPC tumorigenesis and treatment. "
01/01/2020 - "Most of studies on UV carcinogenesis actually focus on DNA damage while their proteome-damaging ability and its contribution to skin carcinogenesis have remained largely underexplored. "
09/01/2007 - "In the present study, we conducted comparative proteomics to analyze the differential proteome of G1 tumour and adjacent non-tumour tissues, with aims to identify the molecules as early tumour markers and to understand the early molecular events involved in initiation of tumorigenesis in hepatitis B virus (HBV)-infected G1 tumour. "

01/01/2009 - "Characterization of the mitochondrial proteome may therefore be extremely useful for identification and validation of targets for therapeutic treatment of human diseases, including aging and age-related disorders, diabetes, and obesity. "
05/01/2005 - "In summary, proteome analysis of muscle has helped us better describe the molecular etiology of obesity-related disease."
01/01/2023 - "We provide an overview of the published papers on the integrated analysis of proteomic and genomic data in obesity and summarize four mainstream strategies: overlap, colocalization, Mendelian randomization, and proteome-wide association studies. "
12/01/2022 - "Altogether, the study's results provide an overview of SSPS-induced changes in the liver proteome, which could help us understand the molecular mechanism by which SSPS alleviates obesity."
01/01/2016 - "Therefore, the aim of our study was to investigate the role of obesity and RYGB on the human skeletal muscle proteome. "