Amyloid (Amyloid Fibrils)

A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.

Also Known As:

Networked: 22775 relevant articles (507 outcomes, 1842 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Blennow, Kaj: 153 articles (12/2015 - 01/2002)
2.	Masters, Colin L: 139 articles (10/2015 - 01/2002)
3.	Zetterberg, Henrik: 131 articles (12/2015 - 05/2004)
4.	Holtzman, David M: 116 articles (11/2015 - 03/2002)
5.	Hyman, Bradley T: 90 articles (12/2015 - 02/2002)
6.	Trojanowski, John Q: 86 articles (12/2015 - 08/2002)
7.	Villemagne, Victor L: 75 articles (01/2016 - 02/2006)
8.	Rowe, Christopher C: 70 articles (10/2015 - 04/2007)
9.	Bush, Ashley I: 69 articles (10/2015 - 05/2002)
10.	Perry, George: 68 articles (05/2014 - 01/2002)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 07/01/2006 - "Most drug discovery efforts for Alzheimer's disease (AD) have focused on prevention or clearance of beta-amyloid (Abeta) fibrils or oligomers, with far less attention to prevention of tau abnormalities that lead to neurofibrillary tangles (NFTs). " 06/01/2010 - "This study deals with the structurally important intermediates and it may help to understand the mechanism of amyloid fibril aggregation leading to the onset of Alzheimer's disease." 01/01/2014 - "Amyloid-β (Aβ) is an important pathogenic player in Alzheimer's disease, and it is cleared from the brain partly by transportation across the BBB. " 06/01/2012 - "camphorata is proven to provide strong neuroprotection in neuron cells and suggested to have the potential of protection against neurotoxicity of amyloid β-protein (Aβ) known as the risk factor toward Alzheimer's disease (AD) development. " 01/13/2012 - "Accumulation of amyloid-beta (Aβ) is one of the hallmarks of Alzheimer's disease (AD), and efficient clearance of Aβ by cells of the innate immune system may be an important mechanism for controlling or preventing disease onset. "
2.	Amyloidosis 07/31/1982 - "These observations support the view that major increases in SAA levels are a necessary condition for the deposition of this form of amyloid and suggest that prospective monitoring of the SAA concentration in predisposing diseases may help to identify those individuals who are most at risk for amyloidosis." 09/01/2003 - "Relapse occurred after 4 years of complete remission, and the second renal biopsy revealed amyloid light-chain (AL)-amyloidosis. " 01/01/2013 - "Noninvasive imaging techniques for amyloidosis are beneficial for early and definite diagnosis of amyloid deposition in the body. " 12/01/2008 - "On the other hand, antioxidative intervention studies in animal models of AD-like amyloidosis show a significant reduction in amyloid beta deposition and behavioral improvements. " 09/01/2000 - "The serum HGF level was significantly elevated in both amyloid light-chain and amyloid A amyloidosis and was a very useful indicator of suspected amyloidosis as well as a potential prognostic indicator. "
3.	Amyloid Plaque 11/01/2004 - "Since active and passive immunization of amyloid precursor protein (APP) gene- transgenic mice showed significant reduction of beta amyloid deposits in the brain and the immunized mice showed improvement in cognitive functions, clinical trials were performed in US and Europe. " 01/01/2004 - "In the past two decades AD research has benefited significantly from the use of genetically engineered cell lines expressing components of the amyloid-generating pathway, as well as from the study of transgenic mice that develop the pathological hallmarks of the disease, mainly neuritic plaques. " 08/01/2012 - "The improved image resolution is sensitive enough to demonstrate an age-dependent increase of amyloid plaque load and a good correlation between the amyloid load measured by μMRI and histology. " 09/15/1987 - "Image analysis disclosed that the cross-sectional size of the large stromal amyloid deposits was significantly greater than those in age-matched patients with lattice corneal dystrophy type I. All patients had a discontinuous band of amyloid (15 to 25 micron wide) in the superficial stroma beneath Bowman's layer, which usually had only one or two small disruptions. " 04/01/2006 - "Better understanding of the mechanisms underlying amyloid formation has led to the development of novel treatment strategies aimed at inhibiting fibrillogenesis or destabilizing existing amyloid deposits. "
4.	Memory Disorders (Memory Loss) 06/29/2012 - "Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice." 07/01/2011 - "We found that the memory deficit in the AD mice was significantly improved by these treatments, but amyloid β deposition was unchanged. " 04/01/2013 - "The purpose of this study was to investigate the protective effects of L-NNNBP on β-amyloid (Aβ) deposition and memory deficits in an AD model of APP/PS1 mice. " 11/01/2011 - "The aim of this study is to evaluate the protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) on learning and (or) memory deficit in aged rats, as well as to explore the possible connection between TSG and the β-amyloid precursor protein (APP) pathway. " 10/14/2015 - "Using a mouse model of AD, we found that genetic reduction of S6K1 improved synaptic plasticity and spatial memory deficits, and reduced the accumulation of amyloid-β and tau, the two neuropathological hallmarks of AD. "
5.	Inflammation 04/01/2012 - "Importantly, an unchanged amyloid beta (Aβ) plaque load, an increase in soluble Aβ42 levels, and an aggravation of some behavioral parameters were noted, raising the question whether suppression of inflammation by nonsteroidal anti-inflammatory drug is beneficial in AD." 09/25/2008 - "This paper will give an overview on the protective effects of HupA, which includes regulating beta-amyloid precursor protein (APP) metabolism, protecting against Abeta-mediated oxidative stress, apoptosis and mitochondrial dysfunction, as well as anti-inflammation. " 06/01/1993 - "Prospective monitoring studies in patients whose JRA-associated inflammatory activity was in remission demonstrated regression of amyloid in 8 patients and no substantial changes in 8 others; however, in 4 further patients with active inflammation, there was accumulation of amyloid. " 03/09/2015 - "In AD mice deficient for TREM2, the CD45(hi)Ly6C(+) macrophages are virtually eliminated, resulting in reduced inflammation and ameliorated amyloid and tau pathologies. " 10/01/2014 - "Astrocytes may contribute to the clearance of amyloid β-peptide (Aβ) and restrict the spread of inflammation in the brain. "

Related Drugs and Biologics

1.	Peptides
2.	Antibodies
3.	tau Proteins (tau Protein)
4.	Amyloid (Amyloid Fibrils)
5.	Proteins (Proteins, Gene)
6.	Amyloid Precursor Protein Secretases (beta-Secretase)
7.	Apolipoproteins
8.	Melphalan (Alkeran)
9.	Apolipoproteins E (ApoE)
10.	Curcumin

Related Therapies and Procedures

1.	Immunotherapy
2.	Stem Cell Transplantation
3.	Therapeutics
4.	Transplants (Transplant)
5.	Injections