Glycogen Synthase Kinase 3 beta

A glycogen synthase kinase-3 type enzyme that functions in ENERGY METABOLISM; EMBRYONIC DEVELOPMENT; and NEUROGENESIS. It is also involved in PROTEIN BIOSYNTHESIS and regulates cell growth and proliferation as a component of the WNT SIGNALING PATHWAY and other signaling pathways. Certain polymorphisms in the GSK3B gene have been associated with PARKINSON DISEASE; ALZHEIMER DISEASE; and BIPOLAR DISORDER.

Also Known As:

Networked: 794 relevant articles (27 outcomes, 85 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Woodgett, James R: 11 articles (05/2010 - 05/2006)
2.	Avila, Jesús: 8 articles (04/2008 - 12/2002)
3.	Jope, Richard S: 8 articles (01/2007 - 04/2002)
4.	Zhu, Min: 7 articles (11/2022 - 06/2006)
5.	Miura, Tetsuji: 7 articles (10/2010 - 08/2006)
6.	Chen, Gang: 7 articles (09/2009 - 07/2004)
7.	Luo, Jia: 7 articles (09/2009 - 07/2004)
8.	Thiemermann, Christoph: 7 articles (09/2008 - 09/2005)
9.	Li, Yan: 6 articles (01/2012 - 07/2005)
10.	Minamoto, Toshinari: 6 articles (12/2009 - 09/2005)

Related Diseases

1.	Reperfusion Injury 12/01/2009 - "In conclusion, with the use of our protocols, EPO showed better protective effects than IPost against reperfusion injury through higher phosphorylation of GSK-3beta." 08/01/2011 - "Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism." 01/01/2016 - "GSK-3beta Inhibitor Induces Expression of Nrf2/TrxR2 Signaling Pathway to Protect against Renal Ischemia/Reperfusion Injury in Diabetic Rats." 06/01/2010 - "Mitochondria and GSK-3beta in cardioprotection against ischemia/reperfusion injury." 07/01/2009 - "GSK-3beta phosphorylation is a step to which multiple protective signaling pathways converge, and thus GSK-3beta phosphorylation is crucial in cardioprotection of a variety of interventions against ischemia/reperfusion injury. "
2.	Neoplasms (Cancer) 07/15/2008 - "These findings identify GSK-3beta signaling as a key regulator of radiation-induced damage in hippocampal neurons and suggest that GSK-3beta inhibitors may have a therapeutic role in protecting both pediatric and adult cancer patients and may help to improve quality of life in cancer survivors." 09/14/2009 - "Our study also demonstrated significant correlation between GSK3beta nuclear localization and tumor grade (p = 0.02), suggesting its association with tumor progression. " 01/01/2007 - "Moreover, recent studies in other human malignancies have implicated GSK-3beta as a regulator of cancer cell proliferation, survival and chemoresistance through distinct mechanisms. " 07/01/2020 - "Glycogen synthase kinase 3 beta (GSK3-β) acts either as a tumor suppressor or an oncogene in various human cancers. " 06/12/2014 - "Glycogen synthase kinase 3 beta (GSK3β) is highly inactivated in epithelial cancers and is known to inhibit tumor migration and invasion. "
3.	Ischemia 11/01/2009 - "Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion." 09/01/2009 - "Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion." 07/01/2010 - "We conclude that diabetes further deteriorates ischemia-induced brain damage and cognitive deficits which may be associated with abnormal phosphorylation of tau as well as activation of GSK-3beta. " 02/01/2010 - "Using in vitro and in vivo models, we tested the hypothesis that GSK3beta promotes Bax-mediated apoptosis, contributing to tubular injury and organ dysfunction after acute renal ischemia. " 05/27/2008 - "Wild-type and transgenic GSK3beta-S9A mice (the cardiac GSK3beta activity of which cannot be inactivated) underwent 60 minutes of ischemia and 24 hours of reperfusion. "
4.	Brain Injuries (Brain Injury) 08/01/2006 - "The present study suggests that the Akt/GSK3beta pathway might be involved in neuronal survival in acute brain injury after SAH." 01/01/2018 - "Glycogen synthase kinase 3 beta (GSK-3β) plays an important role in neurological outcomes after brain injury. " 05/01/2007 - "We conclude that reduction in oxidative stress by SOD1 overexpression may attenuate acute brain injury after SAH via activation of Akt/GSK3beta survival signaling." 08/01/2006 - "Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats." 09/01/2006 - "Our findings suggest that estradiol plays a potent protective role against brain injury and that phosphorylation of Akt and GSK3beta by estradiol mediated these protective effects."
5.	Schizophrenia (Dementia Praecox) 03/01/2008 - "This study examined whether Par-4, beta-arrestin1, AKT1 and GSK-3beta are involved in the pathophysiology of schizophrenia. " 08/01/2004 - "In this study we aimed to find whether the reduction in brain GSK-3beta is reflected in CSF of schizophrenia patients. " 01/01/2004 - "Association study of -1727 A/T, -50 C/T and (CAA)n repeat GSK-3beta gene polymorphisms with schizophrenia." 10/01/2008 - "Since GSK3beta regulation is altered in schizophrenia, polymorphic variation in this gene may affect susceptibility to schizophrenia or treatment response. " 10/01/2008 - "In general, the data suggest that phosphorylation levels of GSK3beta are reduced in schizophrenia, resulting in increased GSK3beta activity. "

Related Drugs and Biologics

1.	Glycogen Synthase Kinase 3 beta
2.	NF-kappa B (NF-kB)
3.	Glucose (Dextrose)
4.	beta Catenin
5.	Proteins (Proteins, Gene)
6.	Glycogen Synthase (Synthase I)
7.	Phosphotransferases (Kinase)
8.	Insulin-Like Growth Factor I (IGF-1)
9.	4- benzyl- 2- methyl- 1,2,4- thiadiazolidine- 3,5- dione
10.	Proto-Oncogene Proteins c-akt (Protein Kinase B)

Related Therapies and Procedures

1.	Ischemic Postconditioning
2.	Drug Therapy (Chemotherapy)
3.	Laminectomy
4.	Therapeutics
5.	Hepatectomy