Transferases

Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor:acceptor group transferase". (Enzyme Nomenclature, 1992) EC 2.

Also Known As:

Networked: 4296 relevant articles (94 outcomes, 406 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cuzzocrea, Salvatore: 7 articles (10/2012 - 08/2002)
2.	Cortes, Jorge: 7 articles (11/2007 - 03/2003)
3.	Peters, W H: 7 articles (01/2001 - 01/2000)
4.	Fukao, Toshiyuki: 6 articles (02/2015 - 12/2004)
5.	Parmar, Devendra: 6 articles (11/2013 - 02/2008)
6.	Saavedra, Joseph E: 6 articles (04/2013 - 06/2004)
7.	Keefer, Larry K: 6 articles (04/2013 - 06/2004)
8.	Agúndez, José A G: 6 articles (10/2008 - 03/2005)
9.	Kantarjian, Hagop: 6 articles (11/2007 - 03/2003)
10.	Kwon, Byoung-Mog: 6 articles (03/2007 - 04/2003)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2002 - "The hypothesis that the inhibition of farnesyl protein transferase (FPTase) may be beneficial in the treatment of certain cancers is finally being clinically tested. " 10/01/1999 - "Patients with cancer also show significantly greater spontaneous ex vivo apoptosis in peripheral blood mononuclear cells (PBMC) compared to normal controls, as measured by a terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) assay. " 07/01/2011 - "Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. " 01/01/2003 - "Sch-66336 (sarasar), a benzocycloheptapyridyl Farnesyl Transferase Inhibitor (FTI), has been found to be effective in cellular proliferation assays and in in vivo oncology models both as a single agent and in combination with other anti-cancer agents. " 06/01/2002 - "Farnesyl transferase inhibitors (FTIs) were previously shown to be effective in modulating tumor growth in Ras-transformed tumor cells. "
2.	Body Weight (Weight, Body) 01/23/2009 - "In situ cell death in hippocampus quantified by Terminal Deoxynucleated Transferase Nick-End Labeling and on ratio of brain to body weight was investigated. " 12/07/2001 - "This may be explained on the basis of body weight, being 3.2 times higher in geese, and by hepatic metabolism, where GSH S-transferase (GST) activity is 2.9-fold higher in geese and presumably has a role in the binding of Pb to GSH and subsequent biliary excretion. " 01/01/1993 - "Effects of change in body weight on serum aminotransferase and gamma-glutamyl transferase levels." 11/01/2012 - "Clinical parameters, e.g., joint edema, body weight and of gamma glutamyl transferase (GGT) activity as an inflammatory marker, have also been determined. " 09/01/2009 - "Liver ALP at all doses, as well as the activity of gamma glutamyl transferase (GGT) at 500 mg/kg body weight was reduced. "
3.	Breast Neoplasms (Breast Cancer) 02/01/2008 - "The aim of this study was to investigate whether polymorphisms in N-acetyl transferase 1 and 2 modify the association between meat consumption and risk of breast cancer. " 03/01/2003 - "Inhibitors of the enzyme farnesyl transferase (FTIs) are now undergoing early-stage clinical trials, including in patients with advanced breast cancer. " 01/01/2015 - "N-acetylglucosaminyl 1-phosphate transferase: an excellent target for developing new generation breast cancer therapeutic." 09/01/2013 - "Two variants in KAT6B, an acetal transferase gene, were identified in six family members of which five were affected with breast cancer and one is the unaffected obligate carrier. " 01/01/2011 - "Previously, we have shown that breast cancer cells with low metastatic potential can be induced into a reversible state of dormancy by farnesyl transferase inhibitors (FTIs). "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/1981 - "Indirect immunofluorescence for terminal transferase enzyme (TdT) was used to study the blasts of 64 patients with acute non-lymphoid leukaemia (ANLL). " 03/01/2005 - "Acute myeloid leukemias (AMLs) are appropriate disease targets in that they express relevant biologic targets such as Ras, MEK, AKT, and others that may depend upon farnesyl protein transferase activity to promote cell proliferation and survival. " 07/01/1994 - "Detection of terminal transferase in acute myeloid leukemia by flow cytometry." 01/01/1990 - "Acute myelogenous leukemia was diagnosed with a weak reaction of red blood cells with anti-A antibody and a decreased level of A-transferase activity. " 03/01/1989 - "Terminal transferase positive acute myeloid leukemia: immunophenotypic characterization and response to induction therapy."
5.	Pancreatic Neoplasms (Pancreatic Cancer) 10/01/1996 - "[Growth inhibition of human pancreatic cancer by farnesyl transferase inhibitor]." 09/01/2003 - "Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor." 11/01/2002 - "A well designed randomized trial of treatment of patients with gemcitabine with or without a farnesyl transferase inhibitor (tried because pancreatic cancers have a high incidence of K- abnormalities) showed no improvement in survival rates. " 10/01/2005 - "A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest oncology group (SWOG 9924) study." 04/01/2005 - "Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases."

Related Drugs and Biologics

1.	Glutathione (Reduced Glutathione)
2.	Alanine (L-Alanine)
3.	Alkaline Phosphatase
4.	Enzymes
5.	tipifarnib (R115777)
6.	Alanine Transaminase (SGPT)
7.	Cholesterol
8.	Aspartic Acid (Aspartate)
9.	DNA (Deoxyribonucleic Acid)
10.	Bilirubin

Related Therapies and Procedures

1.	Oral Administration
2.	Adjuvant Chemotherapy
3.	Intravenous Injections
4.	Withholding Treatment
5.	Blood Transfusion (Blood Transfusions)