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Proto-Oncogene Proteins c-akt (Protein Kinase B)

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A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.

Also Known As:

Protein Kinase B; AKT1 Protein Kinase; AKT2 Protein Kinase; AKT3 Protein Kinase; Akt-alpha Protein; Akt-beta Protein; Akt-gamma Protein; Protein Kinase B alpha; Protein Kinase B beta; Protein Kinase B gamma; Protein-Serine-Threonine Kinase (Rac); Proto-Oncogene Protein Akt; Proto-Oncogene Protein RAC; Proto-Oncogene Proteins c-akt1; Proto-Oncogene Proteins c-akt2; Proto-Oncogene Proteins c-akt3; RAC-PK Protein; Rac Protein Kinase; Rac-PK alpha Protein; Rac-PK beta Protein; Related to A and C-Protein; c-akt Proto-Oncogene Protein; Akt alpha Protein; Akt beta Protein; Akt gamma Protein; Akt, Proto-Oncogene Protein; Protein, akt Proto-Oncogene; Protein, c-akt Proto-Oncogene; Proteins c-akt1, Proto-Oncogene; Proteins c-akt2, Proto-Oncogene; Proteins c-akt3, Proto-Oncogene; Proto Oncogene Protein Akt; Proto Oncogene Protein RAC; Proto Oncogene Proteins c akt; Proto Oncogene Proteins c akt1; Proto Oncogene Proteins c akt2; Proto Oncogene Proteins c akt3; Proto-Oncogene Protein, akt; Proto-Oncogene Protein, c-akt; RAC PK Protein; RAC, Proto-Oncogene Protein; Rac PK alpha Protein; Rac PK beta Protein; Related to A and C Protein; akt Proto Oncogene Protein; alpha Protein, Rac-PK; c akt Proto Oncogene Protein; c-akt, Proto-Oncogene Proteins; c-akt1, Proto-Oncogene Proteins; c-akt2, Proto-Oncogene Proteins; c-akt3, Proto-Oncogene Proteins; akt Proto-Oncogene Protein; c-akt Protein

Networked: 945 relevant articles (23 outcomes, 62 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Maiese, Kenneth: 10 articles (12/2014 - 04/2004)
2.	Chong, Zhao Zhong: 8 articles (12/2012 - 04/2004)
3.	Zhang, Jing: 6 articles (09/2015 - 04/2008)
4.	Xia, Chun: 6 articles (08/2015 - 01/2009)
5.	Zhang, Bing: 6 articles (08/2015 - 01/2009)
6.	Dong, Qihan: 5 articles (01/2015 - 03/2009)
7.	Zhu, Gui-Dong: 5 articles (06/2007 - 09/2002)
8.	Li, Qun: 5 articles (06/2007 - 09/2002)
9.	Flaherty, Keith T: 4 articles (09/2015 - 08/2010)
10.	Yao, Mu: 4 articles (01/2015 - 04/2010)

Related Diseases

1.	Reperfusion Injury 09/01/2012 - "Activation of Akt/protein kinase B mediates the protective effects of mechanical stretching against myocardial ischemia-reperfusion injury." 04/01/2007 - "Thus, it has been established that the activation of the PI3K (Phosphoinositide-3 kinase)/Akt (Protein kinase B, PKB) signaling pathway is essential for protection against ischaemia/reperfusion injury. " 05/01/2014 - "Protein kinase B (PKB/AKT1) formed signaling complexes with mitochondrial proteins and prevented glycolytic energy dysfunction in cultured cardiomyocytes during ischemia-reperfusion injury." 06/01/2006 - "Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury." 05/01/2006 - "Western blot analysis was used to determine phosphorylation of reperfusion injury salvage kinases including protein kinase B/Akt and its downstream targets after 15 min of reperfusion. "
2.	Melanoma (Melanoma, Malignant) 01/01/2015 - "Finally, we found that muc1 promotes melanoma migration through the protein kinase B (Akt) signaling pathway. " 04/01/2012 - "Central role of constitutively active protein kinase B/Akt (PKB) in melanoma drives the search for new targets to abolish its deranged signaling. " 06/01/2010 - "Coupling of mitochondria to store-operated Ca(2+)-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells." 08/29/2005 - "The protein kinase B-RAF is a human oncogene that is mutated in approximately 70% of human melanomas and transforms mouse melanocytes. " 12/15/2002 - "Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression."
3.	Neoplasms (Cancer) 10/01/2006 - "The purpose of the study was to evaluate the use of phospho-Akt in mouse and human skin as a surrogate target for tumor phospho-Akt to measure the effect of antitumor inhibitors of phosphatidylinositol-3-kinase (PI-3-K)/Akt (protein kinase B) signaling. " 10/01/2014 - "Likewise, the phosphatidylinositide 3-kinase (PI3K)/protein kinase B (PKB/Akt) pathway has been determined to play an important role in both stem cell maintenance and tumor development. " 09/01/2014 - "AKT2 (protein kinase B), an important protein in PI3K signaling pathway, is overexpressed in a variety of malignant tumors. " 03/01/2014 - "Protein kinase B (PKB/Akt) is an attractive target for the treatment of tumor. " 01/01/2014 - "Impaired fatty acid synthesis was associated with reduced solid tumor cell proliferation, the formation of cystic lesions in some animals, and decreased phosphorylation of Src and protein kinase B (Akt). "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 09/01/2012 - "Activation of Akt/protein kinase B mediates the protective effects of mechanical stretching against myocardial ischemia-reperfusion injury." 01/01/2014 - "Phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway plays a key role in myocardial ischemia-reperfusion (I/R) injury. " 04/01/2007 - "Recent studies have demonstrated that reactive oxygen species (ROS) mediate myocardial ischemia-reperfusion (I/R) and angiogenesis via the mitogen-activated protein kinases and the serine-threonine kinase Akt/protein kinase B pathways. " 11/01/2007 - "Protection against myocardial ischemia-reperfusion (I/R) injury involves activation of phosphatidylinositol-3-OH kinase (PI3K)- Akt/protein kinase B and p44/42 mitogen-activated protein kinase (MAPK), components of the reperfusion injury salvage kinase (RISK) pathway. " 10/01/2010 - "Leptin-induced protection against myocardial ischemia-reperfusion (I/R) injury involves the activation of the reperfusion injury salvage kinase pathway, incorporating phosphatidylinositol 3-kinase-Akt/protein kinase B and p44/42 MAPK, and the inhibition of the mitochondrial permeability transition pore (MPTP). "
5.	Insulin Resistance 05/01/2008 - "Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance." 03/04/2005 - "S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance." 07/17/2015 - "In addition, we showed that over-expression of PCBP2 ameliorates palmitate (PA)-induced insulin resistance, which was indicated by elevated phosphorylation of protein kinase B (AKT) and glycogen synthase kinase 3β (GSK3β). " 10/02/2015 - "In addition, we showed that interference of PRDX1 ameliorated palmitate-induced insulin resistance in HepG2 cells, which was indicated by elevated phosphorylation of protein kinase B (AKT) and of glycogen synthase kinase-3 (GSK3β). " 08/01/2010 - "To observe the effects of Bushen Tongmai Recipe (, BSTMR) on mRNA and protein expressions of protein kinase B alpha (PKB alpha) in hepatic, adipose, muscular, and ovarian tissues of polycystic ovary (PCO) rats with insulin resistance (IR) and to explore the possible molecular mechanism of BSTMR in treating IR and ovulation dysfunction. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
3.	Protein Kinases (Protein Kinase)
4.	Sirolimus (Rapamycin)
5.	Serine (L-Serine)
6.	Insulin (Novolin)
7.	Proteins (Proteins, Gene)
8.	Phosphatidylinositol 3-Kinases
9.	Threonine (L-Threonine)
10.	Insulin Receptor

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Ligation
4.	Ischemic Postconditioning
5.	Angioplasty (Angioplasty, Transluminal)