Ischemic Postconditioning

The application of repeated, brief periods of vascular occlusion at the onset of REPERFUSION to reduce REPERFUSION INJURY that follows a prolonged ischemic event. The techniques are similar to ISCHEMIC PRECONDITIONING but the time of application is after the ischemic event instead of before.

Also Known As:

Networked: 416 relevant articles (56 outcomes, 81 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Ovize, Michel: 12 articles (04/2015 - 09/2007)
2.	Zhao, Heng: 11 articles (04/2015 - 09/2006)
3.	Liu, Xiuheng: 9 articles (07/2015 - 08/2007)
4.	Chen, Hui: 9 articles (07/2015 - 08/2007)
5.	Chen, Zhiyuan: 8 articles (07/2015 - 08/2007)
6.	Heusch, Gerd: 8 articles (07/2015 - 01/2009)
7.	Ji, Xunming: 8 articles (12/2014 - 06/2011)
8.	Piot, Christophe: 8 articles (03/2014 - 12/2007)
9.	Singh, Nirmal: 7 articles (12/2015 - 03/2007)
10.	Xing, Bianzhi: 7 articles (02/2015 - 08/2007)

Related Diseases

1.	Reperfusion Injury 09/01/2012 - "Ischemic postconditioning was defined as rapid intermittent interruptions of blood flow in the early phase of reperfusion, which has been found to be protective against renal ischemia-reperfusion injury (IRI) in animal models but not in clinical trials.We" 09/01/2014 - "In the present study, we tested the hypothesis that ischemic postconditioning is effective for salvaging ischemic skeletal muscle resulting from limb ischemia-reperfusion injury, and that the mechanism involves expression of HIF-1α. " 05/01/2011 - "The purpose of this study was to investigate the protective effects of ischemic post-conditioning on damage to the barrier function of the small intestine caused by limb ischemia-reperfusion injury. " 12/01/2009 - "This study aimed to contrast the protective effects of ischemic preconditioning and ischemic postconditioning in hepatic ischemia-reperfusion injury in rats. " 08/07/2015 - "Limb remote ischemic postconditioning (RIPostC) has been proved to be a safe and effective measurement of cardioprotection against ischemia-reperfusion injury. "
2.	Ischemia 12/01/2015 - "The neurological outcomes of the remote ischemic preconditioning (4.2 ± 0.4) and ischemic postconditioning (4.6 ± 0.8) groups were significantly improved when compared with the ischemia group (2.2 ± 04). " 01/01/2012 - "It can be concluded that ischemic postconditioning possesses strong protective effects against ischemia reperfusion-induced myocardium oxidative injury in IR rats." 01/01/2012 - "In this study, we try to find the better protocol of limb ischemia postconditioning by observing different protective effects of limb ischemic postconditioning (different strength and time windows in rabbits). " 05/01/2008 - "In the Langendorff perfused rat heart model, ischemic postconditioning (6 cycles of 10 s reperfusion/10 s global ischemia starting at the beginning of reperfusion) increased formazan content, reduced LDH release, improved the recovery of the left ventricular developed pressure, maximal rise/fall rate of left ventricular pressure and rate pressure product (left ventricular developed pressure multiplied by heart rate), attenuated the decrease of coronary flow during reperfusion and increased the isolated cell viability. " 01/01/2007 - "In the Langendorff perfused rat heart model, ischemic postconditioning (6 cycles of 10 s reperfusion/10 s global ischemia starting at the beginning of reperfusion) increased formazan content, reduced LDH release, improved the recovery of the left ventricular developed pressure, maximal rise/fall rate of left ventricular pressure, left ventricular end-diastolic pressure and rate pressure product (left ventricular developed pressure multiplied by heart rate), attenuated the decrease of coronary flow during reperfusion and increased the isolated cell viability. "
3.	Myocardial Infarction 03/13/2012 - "Myocardial infarct size was increased in uremic animals, but all 3 conditioning strategies (IPC, remote IPC, ischemic postconditioning) proved highly efficacious in reducing myocardial infarct size (relative reduction, 86%, 39%, and 65% [P<0.005, P<0.05, and P<0.05], respectively). " 10/01/2014 - "Ischemic postconditioning during PCI in ST-segment elevation myocardial infarction appears to be superior to PCI alone in reduction of both myocardial injury or damage and improvement in global and regional left ventricular function. " 10/14/2014 - "To evaluate the cardiac protective effects of ischemic postconditioning (IPC) in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI). " 01/01/2014 - "We aimed to summarize the evidence from randomized clinical trials studies examining the efficacy of ischemic postconditioning (IPost) in ST-elevation myocardial infarction. " 05/01/2015 - "In the Effects of Postconditioning on Myocardial Reperfusion in Patients with ST-segment Elevation Myocardial Infarction (POST) trial, ischemic postconditioning failed to improve myocardial reperfusion. "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 10/01/2010 - "Recent studies have shown that ischemic postconditioning reduces myocardial ischemia-reperfusion (I/R) injury; however, the effects of inhibiting apoptosis on cardioprotection induced by ischemic postconditioning remain to be determined. " 10/01/2014 - "Ischemic postconditioning (PoCo) reduces infarct size following myocardial ischemia/reperfusion. " 01/01/2013 - "Notch signaling is known to be activated following myocardial ischemia, but its role in cardioprotection provided by ischemic preconditioning (IPC) and ischemic postconditioning (IPost) remains unclear. " 01/01/2012 - "'Conditioning' [ischemic preconditioning (IPC), ischemic postconditioning (IPO) and remote ischemic preconditioning (RIPC)] the heart to render it more resistant to an episode of acute myocardial ischemia-reperfusion (I/R) injury is an endogenous cardioprotective strategy. " 11/11/2011 - "Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion."
5.	Stroke (Strokes) 02/01/2013 - "Ischemic postconditioning has been established for its protective effects against stroke in animal models. " 11/01/2015 - "Ischemic postconditioning, including early and delayed ischemic postconditioning, has been recognized as a simple and promising strategy in the treatment of stroke. " 10/05/2015 - "It has been reported that ischemic postconditioning (PC) changes the reperfusion pattern in permanent or transient models of stroke and confers neuroprotection. " 09/01/2015 - "Here, we examine the hypothesis that ischemic postconditioning amplifies neurogenesis and angiogenesis during stroke recovery. " 12/01/2014 - "Remote ischemic postconditioning (RIPostC) has been proved to protect the brain from stroke, but the precise mechanism remains not fully understood. "

Related Drugs and Biologics

1.	Cyclosporine (Ciclosporin)
2.	mitochondrial permeability transition pore
3.	Phosphotransferases (Kinase)
4.	Opioid Receptors (Opioid Receptor)
5.	Adenosine
6.	Brain-Derived Neurotrophic Factor (BDNF)
7.	Phosphocreatine (Neoton)
8.	penehyclidine
9.	Sirolimus (Rapamycin)
10.	rosuvastatin (Crestor)

Related Therapies and Procedures

1.	Resuscitation
2.	Stents
3.	Induced Heart Arrest (Cardioplegia)
4.	Angioplasty (Angioplasty, Transluminal)
5.	Transplants (Transplant)