Laminectomy

A surgical procedure that entails removing all (laminectomy) or part (laminotomy) of selected vertebral lamina to relieve pressure on the SPINAL CORD and/or SPINAL NERVE ROOTS. Vertebral lamina is the thin flattened posterior wall of vertebral arch that forms the vertebral foramen through which pass the spinal cord and nerve roots.

Also Known As:

Networked: 3133 relevant articles (198 outcomes, 233 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Cuzzocrea, Salvatore: 37 articles (01/2014 - 10/2004)
2.	Mazzon, Emanuela: 34 articles (01/2015 - 02/2005)
3.	Bramanti, Placido: 31 articles (01/2015 - 02/2005)
4.	Di Paola, Rosanna: 29 articles (01/2014 - 10/2004)
5.	Esposito, Emanuela: 27 articles (01/2014 - 07/2006)
6.	Genovese, Tiziana: 26 articles (08/2011 - 10/2004)
7.	Epstein, Nancy E: 23 articles (01/2015 - 04/2002)
8.	Bydon, Ali: 15 articles (03/2015 - 01/2008)
9.	Gokaslan, Ziya L: 14 articles (10/2015 - 04/2005)
10.	Muià, Carmelo: 14 articles (08/2008 - 02/2005)

Related Diseases

1.	Pain (Aches) 05/01/1989 - "It is clear that for the patient with acute disc displacement with leg-pain as the predominant symptom, simple laminectomy and disc excision will yield good results in most cases. " 03/01/1979 - "Laminectomy is most effective for pain secondary to direct compression of the neural elements. " 04/01/2010 - "Significantly improved axial pain scores with skip laminectomy. " 02/01/2000 - "Electrodes placed through laminectomy furnished significantly greater long-term pain relief than did those placed percutaneously, as measured by a four-tier outcome grading scale (P = 0.02). " 11/01/1984 - "While this operation is effective in many cases, it is seldom successful for pain associated with lumbar disc disease requiring lumbar laminectomy and spine fusion. "
2.	Spinal Cord Diseases 01/01/2015 - "This is a commentary on the article laminoplasty versus laminectomy and fusion (LF) for multilevel cervical myelopathy: A meta-analysis of clinical and radiological outcomes by Chang-Hyun Lee et al. Here, the authors utilized seven studies to compare the efficacy of cervical expansive laminoplasty (EL) versus laminectomy and fusion (LF) to address three or more level multilevel cervical spondylotic myelopathy (CSM). " 05/15/2008 - "Since posterior decompressive laminectomy is not always effective in the treatment of thoracic myelopathy caused by OPLL, circumferential spinal cord decompression through a single posterior approach seems to offer an effective treatment option. " 01/01/2007 - "Spinal canal decompression via cervical laminectomy with or without foraminotomy is a mainstay of treatment of cervical spondylotic myelopathy and myeloradiculopathy. " 01/01/2007 - "With proper patient selection and attention to surgical technique, laminectomy is a safe and effective approach to the management of cervical myelopathy in selected patients." 03/01/2002 - "Skip laminectomy--a new treatment for cervical spondylotic myelopathy, preserving bilateral muscular attachments to the spinous processes: a preliminary report."
3.	Spinal Stenosis (Stenosis, Spinal) 07/01/2010 - "CONCLUSIONS Lumbar laminectomy appears to be the most cost-effective treatment strategy for patients with symptomatic lumbar spinal stenosis." 05/01/2013 - "There is significant clinical improvement after laminectomy and dynamic stabilization with Dynesys for lumbar spinal stenosis. " 01/01/2013 - "There is significant clinical improvement after laminectomy and dynamic stabilization for symptomatic lumbar spinal stenosis. " 07/01/2001 - "Our conclusion in lumbar spinal stenosis diagnosed by objective clinical and radiological findings is that decompressive laminectomy and extensive foraminotomy without instrumentation allow a good outcome." 10/01/1987 - "We conclude that TLS laminectomy is an effective treatment for spinal stenosis if performed early in the course of the neurologic syndrome. "
4.	Pathologic Constriction (Stenosis) 08/01/2005 - "Bilateral and unilateral laminotomy allowed adequate and safe decompression of lumbar stenosis, resulted in a highly significant reduction of symptoms and disability, and improved health-related quality of life. " 10/01/2007 - "In Tema, decompressive lumbar laminectomy for lumbar stenosis achieves significant clinical improvement with attendant low morbidity and mortality rates in patients who have failed conservative treatment. " 02/15/2002 - "Microendoscopic laminotomy can be used to decompress the spinal canal as effectively as an open laminotomy and may prove to be beneficial in decreasing the complications and morbidity of standard treatments for lumbar stenosis." 04/01/1996 - "In conclusion, (a) although instability did not necessarily preclude a good outcome, a poor ambulatory outcome was always associated with instability; (b) laminectomy can effectively ameliorate the symptoms of lumbar stenosis; however, there is a subset of patients in whom laminectomy is associated with instability and a poor clinical course." 04/01/2008 - "The methods of laminectomy, removal of nucleus pulposus, fusion of intra-transverse process and GSS system fixation are effective in treatment of multi-segmental lumbar disc herniation and spinal canal stenosis."
5.	Fibrosis (Cirrhosis) 01/01/1998 - "The study population was culled from a randomized, multicenter clinical trial designed to evaluate the efficacy of a device inhibiting postoperative epidural fibrosis after single-level, unilateral laminectomy/diskectomy for herniated lumbar disk. " 01/01/2014 - "Further investigations under the light of these findings may help to reduce epidural fibrosis formation after laminectomy." 09/01/2014 - "Significance of the mass-compression effect of postlaminectomy/laminotomy fibrosis on histological changes on the dura mater and nerve root of the cauda equina: an experimental study in rats." 01/01/2014 - "It was shown in our study that manuka honey reduces the degree of epidural fibrosis in rats following laminectomy. " 01/01/2014 - "In this study, effects of "manuka honey" on epidural fibrosis development after laminectomy was evaluated in rats. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Hyaluronic Acid (Hyaluronan)
3.	Bupivacaine (Bupivacaine Hydrochloride)
4.	Mitomycin (Mitomycin-C)
5.	Collagen
6.	TNFR-Fc fusion protein (etanercept)
7.	Dexamethasone (Maxidex)
8.	gabapentin (Neurontin)
9.	polylactic acid-polyglycolic acid copolymer (PLGA)
10.	poly(lactic acid) (polylactic acid)

Related Therapies and Procedures

1.	Decompression
2.	Diskectomy (Discectomy)
3.	Laminectomy
4.	Radiotherapy
5.	Injections