HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Proline-Directed Protein Kinases

Subscribe to New Research on Proline-Directed Protein Kinases

A subclass of protein serine-threonine kinases that phosphorylate proteins on a SERINE or THREONINE residue that is immediately preceding a PROLINE residue.

Also Known As:

PDPK Enzymes; Proline-Directed Protein Kinase; Protein-Proline Kinase; Kinase, Proline-Directed Protein; Kinase, Protein-Proline; Kinases, Proline-Directed Protein; Proline Directed Protein Kinase; Proline Directed Protein Kinases; Protein Kinase, Proline-Directed; Protein Kinases, Proline-Directed; Protein Proline Kinase

Networked: 26 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Phosphotransferases: 30637
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9706
        Protein-Serine-Threonine Kinases: 1353
        Proline-Directed Protein Kinases: 26
        Mitogen-Activated Protein Kinases: 952
        Cyclin-Dependent Kinases: 639
        Glycogen Synthase Kinase 3: 493

Experts

1.	Yang, Shiaw-Der: 6 articles (08/2006 - 08/2002)
2.	Fu, Hsiao-Hui: 4 articles (08/2006 - 08/2002)
3.	Hsu, C P: 4 articles (10/2001 - 03/2000)
4.	Yang, C C: 4 articles (10/2001 - 03/2000)
5.	Yang, S D: 4 articles (10/2001 - 03/2000)
6.	Peng, Chien-Chung: 2 articles (11/2002 - 08/2002)
7.	Yang, Chuan-Ching: 2 articles (11/2002 - 08/2002)
8.	Chung, Yuan-Chiang: 2 articles (11/2002 - 08/2002)
9.	Chang, King-Jen: 2 articles (11/2002 - 08/2002)
10.	Hsu, Chih-Ping: 2 articles (11/2002 - 08/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2000 - "Initial clinic studies revealed that the overexpression of proline-directed protein kinase F(A) (PDPK F(A)) is associated conversely with various stages of tumor tissue differentiation. " 09/01/2005 - "Proline-directed protein kinase F(A) (PDPK F(A)) has been established as a multisubstrate/multifunctional PDPK essential for the development of highly malignant phenotypes and rapid progression of lethal cancers. " 09/01/2005 - "Proline-directed protein kinase FA as a new signal transducing target for lethal cancer treatment." 11/01/2004 - "Proline-directed protein kinase FA (PDPK FA) was originally identified as a phosphatase activating factor (FA) but has subsequently been characterized as a multisubstrate/multifunctional PDPK possibly associated with human cancers. " 11/01/2004 - "Proline-directed protein kinase FA as a potential target for diagnosis and therapy of human cancers."
2.	Carcinoma (Carcinomatosis) 11/01/2002 - "Initial studies revealed that the multisubstrate proline-directed protein kinase F(A) (PDPK F(A)) is overexpressed in various types of human carcinomas relative to normal controls. " 11/01/2002 - "Association of proline-directed protein kinase FA with tumorigenesis, invasion, and poor prognosis of human colon carcinoma." 08/15/2002 - "It has been shown previously that proline-directed protein kinase F(A) (PDPK F(A)) is overexpressed in various human malignancies compared with its expression in normal controls, and the suppression of overexpressed PDPK F(A) is capable of inhibiting the growth of various types of human carcinoma cells, suggesting a role for this PDPK in human malignancies. " 08/15/2002 - "Association of overexpressed proline-directed protein kinase F(A) with chemoresistance, invasion, and recurrence in patients with bladder carcinoma." 10/01/2001 - "Previously, the authors reported that specific antisense suppression of overexpressed proline-directed protein kinase (PDPK) F(A) enhances the chemosensitivity of various clinical anticancer drugs up to > 100-fold in human prostate carcinoma cells, suggesting an association of PDPK F(A) with drug resistance in human malignancies. "
3.	Alzheimer Disease (Alzheimer's Disease) 01/15/2000 - "The present study examined changes in tau phosphorylation and localization in response to osmotic stress, which activates the stress-activated protein kinases (SAPKs), a family of proline-directed protein kinases shown to phosphorylate tau in vitro and hypothesized to phosphorylate tau in Alzheimer's disease. " 01/01/1997 - "A number of studies have implicated a proline-directed protein kinase, glycogen synthase kinase-3 (GSK-3) in the hyperphosphorylation of tau in Alzheimer's disease (AD). " 01/01/1997 - "Recent in vitro data suggest that mitogen-activated protein kinase (MAPK), a proline-directed protein kinase, phosphorylates the sites on tau common to Alzheimer's disease. " 05/21/1993 - "Antibody SMI33 recognizes neurofibrillary tangles after treatment with alkaline phosphatase, suggesting that the proline-directed protein kinase may phosphorylate tau at sites that are phosphorylated in Alzheimer's disease." 11/01/2010 - "The dual-specificity tyrosine(Y)-phosphorylation-regulated kinase 1A (Dyrk1A) gene is located on human chromosome 21 and encodes a proline-directed protein kinase that might be responsible for mental retardation and early onset of Alzheimer's disease (AD) in Down syndrome (DS) patients. "
4.	Pheochromocytoma 04/25/1990 - "Previous studies identified synapsin I as a potential substrate for a newly discovered growth factor-sensitive, proline-directed protein kinase originally isolated from rat pheochromocytoma. " 09/25/1989 - "Additional findings indicate that the activity of proline-directed protein kinase is increased transiently in PC12 pheochromocytoma cells following treatment with nerve growth factor. " 09/15/1991 - "Site-specific analysis of tyrosine hydroxylase phosphorylation in rat pheochromocytoma led previously to the identification of a novel growth factor-sensitive serine/threonine protein kinase, designated proline-directed protein kinase (PDPK). "
5.	Neoplasm Metastasis (Metastasis) 08/10/2006 - "Molecular, cellular, and animal studies have established that overexpressed proline-directed protein kinase F(A) (PDPK F(A)) is essential for the development of tumorigenesis, invasion, and metastasis of human cancer cells. "

Related Drugs and Biologics

1.	Protein Kinases (Protein Kinase)
2.	Glycogen Synthase (Synthase I)
3.	Phosphotyrosine
4.	Synapsins (Synapsin I)
5.	Flavonoids
6.	Tyrosine (L-Tyrosine)
7.	Threonine (L-Threonine)
8.	Serine (L-Serine)
9.	Phosphotransferases (Kinase)
10.	Antibodies

Related Therapies and Procedures

1.	Aftercare (After-Treatment)