Glycogen Synthase Kinases

A class of protein-serine-threonine kinases that was originally found as one of the three types of kinases that phosphorylate GLYCOGEN SYNTHASE. Glycogen synthase kinases along with CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASES and CYCLIC AMP-DEPENDENT PROTEIN KINASES regulate glycogen synthase activity.

Also Known As:

Networked: 435 relevant articles (10 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Minamoto, Toshinari: 8 articles (02/2015 - 01/2006)
2.	Kawakami, Kazuyuki: 6 articles (10/2013 - 01/2006)
3.	Nakada, Mitsutoshi: 5 articles (02/2015 - 02/2009)
4.	Lin, Chiou-Feng: 5 articles (11/2014 - 09/2009)
5.	Motoo, Yoshiharu: 5 articles (01/2013 - 01/2006)
6.	Thiemermann, Christoph: 5 articles (01/2012 - 01/2007)
7.	Werstuck, Geoff H: 4 articles (05/2015 - 01/2006)
8.	Chen, Chia-Ling: 4 articles (11/2014 - 09/2009)
9.	Shimasaki, Takeo: 4 articles (01/2013 - 12/2009)
10.	Huang, Wei-Ching: 4 articles (06/2012 - 09/2009)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2009 - "Furthermore, we found a significant reduction in the levels of glycogen synthase kinase 3beta (GSK-3beta) protein in the tumors relative to OB. " 05/01/2015 - "Clinical significance of inactivated glycogen synthase kinase 3β in HPV-associated cervical cancer: Relationship with Wnt/β-catenin pathway activation." 03/01/2015 - "In the absence of Wnt signal (off-state), β-catenin prevents phosphorylation of glycogen synthase kinase (GSK)-3β leading to aberrant nuclear accumulation in human tumors. " 10/01/2014 - "Emerging evidence indicates that activation of Wnt/β-catenin signaling at the cell surface results in inhibition of glycogen synthase kinase 3β (GSK3β), leading to activation of mTORC1 signaling in cancer cells. " 01/01/2013 - "Glycogen synthase kinase 3β (GSK3β) regulates multiple cellular pathways and is implicated in various diseases including cancer. "
2.	Myocardial Infarction 12/01/2008 - "We investigated the role of the Akt-glycogen synthase kinase (GSK)-3beta signalling pathway in mediating the protective effects of tissue kallikrein on myocardial injury by promoting angiogenesis and blood flow in rats after myocardial infarction (MI). " 05/01/2006 - "Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo." 03/15/2015 - "Overexpression of protein phosphatase 2A in a murine model of chronic myocardial infarction leads to increased adverse remodeling but restores the regulation of β-catenin by glycogen synthase kinase 3β."
3.	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 06/01/2012 - "Binding of adenomatous polyposis coli (APC) to the microtubule plus ends in polarized cells is regulated by glycogen synthase kinase 3β (GSK-3β). " 10/28/2011 - "Expression of β-catenin is strictly regulated in normal cells via the glycogen synthase kinase 3β (GSK3β)- adenomatous polyposis coli-axin-mediated degradation pathway. " 05/01/2011 - "Activation of this signaling pathway causes disruption of the Axin/adenomatous polyposis coli/glycogen synthase kinase 3β complex, resulting in stabilization of β-catenin and its association with lymphoid enhancer factor/T-cell factor in the nucleus. " 01/28/1999 - "The adenomatous polyposis coli (APC) tumour-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin. " 07/01/2011 - "Hypoxia significantly decreased β-catenin protein, but had no effect on glycogen synthase kinase (GSK)-3β or adenomatous polyposis coli (APC) levels. "
4.	Reperfusion Injury 10/24/2008 - "Inhibition of glycogen synthase kinase (GSK)-3 reduces ischemia/reperfusion injury by mechanisms that involve the mitochondria. " 05/01/2006 - "Inhibition of glycogen synthase kinase (GSK)-beta protects against ischemia-reperfusion injury. " 02/01/2012 - "Therefore, in this study, we aimed to investigate whether delayed administration of parecoxib inhibited mitochondria-mediated neuronal apoptosis induced by ischemic reperfusion injury via phosphorylating Akt and its downstream target protein, glycogen synthase kinase 3β (GSK-3β). " 11/01/2015 - "Diverse transmitting pathways trigger a variety of signaling cascades, including the reperfusion injury salvage kinase and survivor activating factor enhancement pathways, all of which converge on glycogen synthase kinase 3β (GSK3β). " 11/01/2013 - "Role of glycogen synthase kinase 3β in protective effect of propofol against hepatic ischemia-reperfusion injury."
5.	Diabetic Cardiomyopathies 05/01/2015 - "As Wnt/β-catenin/glycogen synthase kinase 3β (GSK3β) signaling has been implicated in myocardial injury and diabetic cardiomyopathy (DCM) is a major part of diabetic cardiovascular complications, we therefore investigated the alterations of Wnt/β-catenin/GSK3β signaling during the development of DCM. " 01/01/2011 - "The present study was to investigate the role of kinin B2 receptor-Akt-glycogen synthase kinase (GSK)-3β signalling pathway in mediating the protective effects of tanshinone IIA (TSN) on diabetic cardiomyopathy. " 04/03/2006 - "Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol."

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	beta Catenin
3.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
4.	4- benzyl- 2- methyl- 1,2,4- thiadiazolidine- 3,5- dione
5.	tanshinone
6.	Lithium
7.	Cyclins
8.	Cyclooxygenase 2 (Cyclooxygenase-2)
9.	Isoflurane
10.	indirubin

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Transplantation (Transplant Recipients)
4.	Castration