Phosphotransferases (Kinase)

A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.
Also Known As:
Kinase; Kinases; ATP Phosphotransferases; Phosphotransferases, ATP; Transphosphorylases
Networked: 30637 relevant articles (693 outcomes, 2500 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Grant, Steven: 54 articles (05/2015 - 01/2002)
2. Dent, Paul: 51 articles (09/2015 - 01/2002)
3. Druker, Brian J: 48 articles (12/2015 - 03/2002)
4. Gray, Nathanael S: 47 articles (09/2015 - 12/2007)
5. Heinrich, Michael C: 47 articles (03/2015 - 03/2002)
6. Salgia, Ravi: 45 articles (06/2015 - 01/2003)
7. Lang, Florian: 42 articles (09/2015 - 01/2002)
8. Zhang, Wei: 42 articles (08/2015 - 11/2002)
9. Alessi, Dario R: 42 articles (08/2015 - 12/2002)
10. Rosen, Neal: 37 articles (12/2015 - 06/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Melanoma (Melanoma, Malignant)
3. Breast Neoplasms (Breast Cancer)
07/01/2002 - "In this study, we explored the efficacy of a type 5 recombinant adenovirus encoding a kinase dead form of ErbB-2, AderbB-2 Delta tk, as a potential therapeutic agent for breast cancer using a murine breast model expressing constitutively active ErbB-2. "
11/15/2010 - "However, they also indicate that patient stratification based on expression/activation of drug targets, coupled with use of multi-kinase inhibitors or combination therapies, may be required for effective treatment of this breast cancer subgroup."
03/01/2013 - "In the present study, in order to optimize the efficacy of replication-defective adenoviral and lentiviral vectors for gene therapy, RT-PCR was used to evaluate the expression of Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) in the Bcap37 human breast cancer cell line, dThd was used to determine the activity of Dm-dNK, cell cytotoxicity was evaluated by MTT assay and cell proliferation was assessed using a hemocytometer. "
08/01/2012 - "The aim of this study was to evaluate the selective killing efficacy of adenovirus (Ad)-mediated double suicide genes driven by the kinase domain-containing receptor (KDR) promoter in human breast cancer cells and vascular endothelial cells. "
01/01/2007 - "All of these concepts are being revisited with respect to the efficacy of HER family TKI therapies; in particular, HER3 signalling buffered against incomplete inhibition of HER2 kinase activity has been suggested to be the mechanism that allows HER2 over-expressing breast cancer cells to escape HER TKIs. "
4. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
5. Reperfusion Injury

Related Drugs and Biologics

1. tyrosine receptor (receptor, tyrosine)
2. imatinib (Gleevec)
3. Tyrosine (L-Tyrosine)
4. Cyclins
5. Protein Kinases (Protein Kinase)
6. sorafenib (BAY 43-9006)
7. sunitinib (Sutent)
8. Protein-Tyrosine Kinases (Tyrosine Kinase)
9. Sirolimus (Rapamycin)
10. Phosphotransferases (Kinase)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)
3. Therapeutics
4. Molecular Targeted Therapy
5. Aftercare (After-Treatment)