HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Reperfusion Injury

Subscribe to New Research on Reperfusion Injury

Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.

Also Known As:

Injury, Ischemia-Reperfusion; Injury, Reperfusion; Reperfusion Damage; Damage, Reperfusion; Damages, Reperfusion; Injuries, Ischemia-Reperfusion; Injuries, Reperfusion; Injury, Ischemia Reperfusion; Ischemia Reperfusion Injury; Ischemia-Reperfusion Injuries; Reperfusion Damages; Reperfusion Injuries; Ischemia-Reperfusion Injury

Networked: 15492 relevant articles (1694 outcomes, 2100 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Ischemia
2.	Myocardial Ischemia (Ischemic Heart Diseases)
3.	Brain Ischemia (Cerebral Ischemia)
4.	Inflammation
5.	Myocardial Infarction

Experts

1.	Busuttil, Ronald W: 64 articles (03/2015 - 01/2002)
2.	Kupiec-Weglinski, Jerzy W: 56 articles (03/2015 - 01/2002)
3.	Cuzzocrea, Salvatore: 49 articles (02/2013 - 01/2002)
4.	Gao, Feng: 48 articles (10/2015 - 05/2002)
5.	Yellon, Derek M: 43 articles (12/2015 - 10/2002)
6.	Thiemermann, Christoph: 38 articles (03/2013 - 01/2002)
7.	Lee, H Thomas: 36 articles (11/2014 - 01/2002)
8.	Kron, Irving L: 35 articles (12/2015 - 04/2002)
9.	Kukreja, Rakesh C: 32 articles (05/2015 - 03/2002)
10.	Laubach, Victor E: 31 articles (12/2015 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Reperfusion Injury:

1.	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/01/2003 - "These findings support the role of nitric oxide as an important mediator in the protection against skin flap ischemia/reperfusion injury." 05/01/2004 - "Nitric oxide has been reported to be beneficial in preserving muscle viability following ischemia-reperfusion injury. " 04/15/1999 - "Thus, our results suggest that supplement of nitric oxide during reperfusion is effective in attenuating exocrine microvascular reperfusion injury." 10/01/2015 - "Nitric oxide was shown to have protective effects on ischemia/reperfusion injury. " 07/27/2014 - "Mechanisms of hepatic ischemia-reperfusion injury and protective effects of nitric oxide."
2.	OxygenIBA 08/01/2008 - "Experimental studies have suggested that hyperoxemia provided by hyperbaric oxygen may be beneficial in the treatment of reperfusion injury. " 08/01/1990 - "In conclusion, leukocyte depletion by in vivo use of leukocyte filter was effective for reperfusion injury of warm ischemic lung and oxygen metabolites may play a role in these process." 04/01/1994 - "Drugs that scavenge or inhibit the formation of reactive oxygen metabolites and/or prevent the recruitment of PMN may be useful in the treatment of reperfusion injury." 09/01/1996 - "Improvement in alveolar-arterial oxygen gradient and reduction in extravascular lung water during the study period imply that the ischemia-reperfusion injury induced by this model is reversible. " 01/01/2015 - "Oxygen Insufflation in University of Wisconsin Solution Ameliorates Reperfusion Injury in Small Bowel after Cold Storage and Reperfusion."
3.	Superoxide DismutaseIBA 10/01/1999 - "Superoxide dismutase (SOD) is a potent candidate for myocardial protection against ischemia-reperfusion injury; however, its clinical significance by means of exogenous administration remains controversial. " 07/01/2012 - "Serum superoxide dismutase activity was significantly higher in group 2 than in group 3. The ratios of bilateral testicular weight, mean seminiferous tubule diameter, and germinal epithelial cell thickness were significantly higher in group 5 than in group 4. Therapy with EGCG before reperfusion might exert protective effects via antioxidant activities in a rat experimental model of testicular ischemia-reperfusion injury." 03/01/1997 - "Furthermore, the hearts transfected with manganese-superoxide dismutase showed significant improvement in tolerance against ischemia reperfusion injury. " 03/01/1991 - "The results indicate that retroinfusion of superoxide dismutase into the great cardiac vein before reperfusion may be an effective treatment for the prevention of reperfusion injury, even in the absence of a well developed coronary collateral circulation. " 01/01/2003 - "This study confirms the protective effects of superoxide dismutase against ischemia-reperfusion injury. "
4.	MelatoninIBA 05/06/2010 - "In rodent studies melatonin has been shown to be highly effective in limiting abnormal cardiac physiology and the loss of critical heart tissue resulting from ischemia/reperfusion injury. " 01/01/2013 - "The protection against endothelial damage, vasoconstriction, platelet aggregation and leukocyte infiltration might contribute to the beneficial effects against ischemia-reperfusion injury by melatonin. " 12/01/2010 - "In the present skeletal muscle acute I/R injury model, protective effects of melatonin against reperfusion injury have been revealed. " 12/01/2010 - "[Protective effects of melatonin on ischemia-reperfusion injury of skeletal muscle]." 07/01/2003 - "The protective effects of physiological and pharmacological concentrations of melatonin on renal ischemia-reperfusion injury in rats."
5.	Adenosine Triphosphate (ATP)IBA 07/01/2004 - "The above results, therefore, suggest to us that IP by activation of K(ATP) channels can afford protection against the ischemia-reperfusion injury in the hypertrophied heart." 07/01/2004 - "In this study we have demonstrated the role of ischemic preconditioning (IP) in preventing the reperfusion injury of the hypertrophied heart by activation of the depleted K(ATP) channels. " 07/15/1996 - "This study examines the effect of intestinal reperfusion injury (IIR) on renal blood flow and relates this temporally to changes in renal ATP levels and renal tubular function. " 01/01/1989 - "From this study it was concluded that PEP and ATP partially protect skeletal muscle from ischaemia and reperfusion injury." 12/01/2015 - "δPKC interaction with the d subunit of F1Fo ATP synthase impairs energetics and exacerbates ischemia/reperfusion injury in isolated rat hearts."
6.	Adenosine FDA LinkGeneric 09/01/2001 - "In contrast, in the cardiac and pulmonary systems, postischemic adenosine has potent anti-inflammatory attributes and is protective against reperfusion injury via activation of A(2a) ARs. " 11/01/2009 - "Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts." 11/01/1991 - "Thus, administration of adenosine or potentiators of adenosine production in the ischemic myocardium may be beneficial for the attenuation of ischemic and reperfusion injuries, although further clinical investigations are necessary." 06/19/1997 - "Adenosine, a theoretically attractive agent for preventing reperfusion injury, has shown promise in small, clinical studies, and appears to be an endogenous substance involved in the protective effect of ischemic preconditioning. " 05/01/2002 - "[Adenosine production and its role in protection against ischemic and reperfusion injury of the myocardium]."
7.	Phosphotransferases (Kinase)IBA 01/01/2008 - "The demonstration that the protective effects of the cytokine were dependent on PI3-kinase/Akt and ERK1/2 activation provides compelling evidence that reperfusion injury salvage kinases (RISKs) are key survival mechanisms in human myocardium, as they are in experimental animal species. " 02/24/2012 - "Extracellular-regulated-kinase 5-mediated renal protection against ischemia-reperfusion injury." 01/01/2016 - "Growing evidence from basic and clinical studies demonstrates that a DPP-4 inhibitor could exert cardioprotection and improve left ventricular function by reducing oxidative stress, apoptosis, and increasing reperfusion injury salvage kinase (RISK) activity. " 07/05/2015 - "In this study, we investigated whether cardioprotection induced by NP202 depended on activation of the reperfusion injury survival kinase (RISK) pathways. " 02/27/2015 - "In this study, we investigated the roles of reperfusion injury salvage kinase (RISK) and apoptosis-related pathways in the attenuation of cardioprotection of IPoC in the presence of HC. "
8.	Acetylcysteine (Siran)FDA LinkGeneric 06/01/2005 - "Because N-acetyl-L-cysteine (NAC) was effective in attenuating lung reperfusion injury, its properties on aortic dysfunction were tested. " 01/01/2007 - "Numerous studies performed in recent years have shown protective effects of N-acetylcysteine (NAC) on cardiac and renal tissue damage following ischemia/reperfusion injury. " 08/01/1995 - "Protective effects of N-acetylcysteine on hypothermic ischemia-reperfusion injury of rat liver." 11/01/2005 - "N-Acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosis." 05/18/2010 - "High-dose N-acetylcysteine reduced the incidence of contrast-induced nephropathy in patients with high contrast volumes and reduced reperfusion injury in animal trials. "
9.	Allopurinol (Remid)FDA LinkGeneric 03/01/1995 - "Is allopurinol beneficial in the prevention of renal ischaemia-reperfusion injury in the rat?: evaluation by near-infrared spectroscopy." 07/01/1993 - "The present study suggests that allopurinol protection against ischemia-reperfusion injury may involve generalized alterations in tissue antioxidant status, and that the measurement of erythrocyte susceptibility to oxidative challenge could provide a useful approach to optimizing the effectiveness of therapeutic interventions undertaken prior to surgery in order to minimize the risk of damage resulting from postischemic tissue reperfusion." 08/01/1990 - "We conclude that enteral allopurinol in the presently available form and dose is effective in reducing mesenteric reperfusion injury." 04/01/1990 - "Allopurinol is effective in reducing reperfusion injury in the currently available enteral form in dose ranges that should not cause prohibitive side effects." 01/01/2013 - "Protective effects of reducing renal ischemia-reperfusion injury during renal hilar clamping: use of allopurinol as a nephroprotective agent."
10.	Retinaldehyde (Retinal)IBA 01/01/2011 - "AG provides retinal protection against ischemia-reperfusion injury in rat retina, probably through an inducible NOS-dependent mechanism." 10/01/2008 - "These results indicate that LPS provides retinal protection against ischemia-reperfusion injury in a dose-dependent manner, probably through an inducible NOS-dependent mechanism." 01/01/2012 - "The purpose of this study was to report a rare case of retinal reperfusion injury after optic nerve sheath fenestration surgery. " 11/01/2009 - "In another study by us, ROCK inhibitor showed neuroprotective effects against rat retinal ischemia reperfusion injury. " 12/01/2008 - "In this study, we explored the expression of SDF-1 in a rat model of retinal ischemia-reperfusion injury and investigated the possible role of retinal microvasculature endothelium cells in generation of this chemokine. "

Therapies and Procedures

1.	Transplants (Transplant) 11/01/2012 - "3. Our experience with liver HMP is the only reported clinical experience worldwide representing a total of 41 successful liver transplant cases showing improved outcomes and diminished markers of ischemia/reperfusion injury. " 09/01/2005 - "Thus, it is conceivable that prevention of ischemia-reperfusion injury by HO-1 overexpression also might be beneficial for reduced-size liver grafts without affecting their proliferative capacity." 01/01/2005 - "FR183998 may be considered beneficial for ischemia/reperfusion injury to pancreatic grafts from NHBDs." 02/01/2002 - "Protection against ischemia-reperfusion injury, acute and/or chronic rejection without significant side effects would be a major breakthrough in transplant research. " 02/01/1999 - "After 1 hour of reperfusion, gas exchange function and tissue lipid peroxide levels were significantly improved in Lazaroid-treated groups III, and V compared with no treatment group I. Histologic damage was less severe in groups III, IV, and V than in group I. These findings suggest that Lazaroid U74389G ameliorates ischemia-reperfusion injury in the rat lung transplants by inhibiting lipid peroxidation, regardless of whether it is administrated intravenously or given as an additive to the preservation solution."
2.	Transplantation (Transplant Recipients) 03/01/2011 - "Cold storage in HTK exhibited superior protective effects against ischemia-reperfusion injury of hearts from older donors in this rat transplantation model." 01/01/1997 - "Emphasized antiviral prophylaxis and treatment, improved preservation and prevention of ischaemia reperfusion injury are other means presently available to obtain better results after intestinal transplantation in the near future. " 03/01/2013 - "The therapeutic efficacy of mesenchymal stem cell (MSC) transplantation has recently been attributed to exosomes when a single bolus of MSC exosomes prior to reperfusion of ischemic myocardium ameliorates reperfusion injury and reduces infarct size. " 06/01/2005 - "NO has protective effects on the ischemia/reperfusion injury of pancreaticoduodenal transplantation." 08/01/2004 - "NO has protective effects on ischemia/reperfusion injury in pancreaticoduodenal transplantation."
3.	Lung Transplantation 09/01/1997 - "Antioxidant treatment with lazeroids has proven beneficial for the amelioration of reperfusion injury in experimental lung transplantation. " 09/01/1991 - "The above results suggest that EC-SOD plays an important role in cyto-protection against reperfusion injury after lung transplantation." 06/01/2002 - "However, Group 3 had improved pulmonary artery pressure, peak inspiratory pressure, arterial oxygenation, and wet-to-dry weight ratio measurements compared with Group 2. High-flow reperfusion results in severe reperfusion injury after lung transplantation. " 04/01/2011 - "The aim of this study was to investigate whether intratracheal administration of a new synthetic surfactant that includes the cationic, hydrophobic 21-residue peptide KLLLLKLLLLKLLLLKLLLLK (KL₄), might be effective in reducing ischaemia-reperfusion injury after lung transplantation. " 04/01/1999 - "In this study, transforming growth factor-beta1 was transfected to proximal pulmonary artery segments, and the efficacy of transforming growth factor-beta1 transfection was examined in ischemia-reperfusion injury and acute rejection models of rat lung transplantation. "
4.	Homologous Transplantation (Allograft) 09/01/1997 - "In the swine model the decrease flow from baseline in allograft post-reperfusion renal blood flow was significantly greater in kidneys preserved in Collins'-2 than in University of Wisconsin solution (41.75 +/- 5.69 versus 11.18 +/- 13.99 ml. per minute, p = 0.005), supporting that this technique can assess mild to moderate reperfusion injury. " 03/27/2000 - "Hyperbaric pressure is a safe and effective vector for the ex vivo delivery of AS-ICAM-1-ODN to rodent cardiac allografts and results in a reduction in reperfusion injury." 07/01/1999 - "In view of these protective effects and its low toxicity in humans, GSH should be considered a candidate drug for prevention of ROS-related reperfusion injury of the liver allograft." 04/01/2012 - "Its ability to attenuate ischemia-reperfusion injury translates to reduction in ischemia-reperfusion injury with improved early allograft function. " 12/01/2015 - "Experimental and clinical studies in solid organs and VCA have confirmed that MSCs facilitate immunosuppression-free allograft survival or tolerance, stimulate peripheral nerve regeneration, attenuate ischaemia-reperfusion injury, and improve tissue healing after surgery. "
5.	Ischemic Postconditioning 09/01/2012 - "Ischemic postconditioning was defined as rapid intermittent interruptions of blood flow in the early phase of reperfusion, which has been found to be protective against renal ischemia-reperfusion injury (IRI) in animal models but not in clinical trials.We" 09/01/2014 - "In the present study, we tested the hypothesis that ischemic postconditioning is effective for salvaging ischemic skeletal muscle resulting from limb ischemia-reperfusion injury, and that the mechanism involves expression of HIF-1α. " 05/01/2011 - "The purpose of this study was to investigate the protective effects of ischemic post-conditioning on damage to the barrier function of the small intestine caused by limb ischemia-reperfusion injury. " 12/01/2009 - "This study aimed to contrast the protective effects of ischemic preconditioning and ischemic postconditioning in hepatic ischemia-reperfusion injury in rats. " 08/07/2015 - "Limb remote ischemic postconditioning (RIPostC) has been proved to be a safe and effective measurement of cardioprotection against ischemia-reperfusion injury. "