Macromolecular Substances

Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.

Also Known As:

Networked: 64 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Veitia, Reiner A: 3 articles (06/2015 - 08/2009)
2.	Karganov, M Yu: 3 articles (05/2005 - 09/2002)
3.	Rumyantseva, E I: 3 articles (05/2005 - 09/2002)
4.	Kovaleva, O I: 3 articles (05/2005 - 09/2002)
5.	Kovalev, I E: 3 articles (05/2005 - 09/2002)
6.	Arora, Kavisha: 2 articles (12/2015 - 10/2015)
7.	Naren, Anjaparavanda P: 2 articles (12/2015 - 10/2015)
8.	Zhang, Weiqiang: 2 articles (12/2015 - 10/2015)
9.	Yarlagadda, Sunitha: 2 articles (12/2015 - 10/2015)
10.	Birchler, James A: 2 articles (01/2014 - 11/2012)

Related Diseases

1.	Infection 01/01/2011 - "The term toxin was introduced by Roux and Yersin and describes macromolecular substances that, when produced during infection or when introduced parenterally or orally, cause an impairment of physiological functions that lead to disease or to the death of the infected organism. " 03/01/2005 - "Vad1 was located within macromolecular complexes that formed cytoplasmic granular bodies in mature cells and during infection of mouse brain. " 10/03/2014 - "In this study, we focused on the composition of important macromolecular complexes of Pseudomonas aeruginosa involved in transcription, DNA replication, fatty acid biosynthesis, RNA regulation, energy metabolism, and cell division during infection with members of seven distinct clades of lytic phages. " 04/01/1993 - "Examples of excellent visualization of the ultrastructure of macromolecular complexes (nucleic acids, extracellular material, membranes etc.), small organisms (bacteria, algae, cyanobacteria and fungi) and large biological samples such as plant and animal tissue as well as the plant-pathogen (fungus) interface and infection structures are presented. " 06/01/1950 - "The effect of bacteria, bacterial and other polysaccharides, and various macromolecular substances of influenzal infection in mice and on haemagglutination by influenza viruses and chemical agents."
2.	Typhoid Fever (Typhoid) 11/01/1971 - "[Study of the content of macromolecular compounds in continuous cultivation of typhoid bacteria. " 05/01/1971 - "[Content of macromolecular compounds in continous cultivation of typhoid bacteria. "
3.	Polyploidy 01/01/2014 - "Molecular evolution studies found that genes encoding members of macromolecular complexes were preferentially retained following polyploidy and underrepresented in copy number variants. " 11/01/2012 - "Following polyploidy formation, members of macromolecular complexes persist in the evolutionary lineage longer than random genes and a complementary pattern is found for segmental duplications in that there is an underrepresentation of members of macromolecular complexes. "
4.	Diarrhea 10/01/2015 - "Our study provides insight into the mechanism of pathophysiologic occurrence of diarrhea in UC and suggests that targeting CFTR and CFTR-containing macromolecular complexes will ameliorate diarrheal symptoms and improve conditions associated with inflammatory bowel disorders. " 12/01/2015 - "Drugs that perturb CFTR-containing macromolecular complexes in the intestinal epithelium and upregulate intracellular cAMP and/or cGMP levels can hyperactivate the CFTR channel, causing excessive fluid secretion and secretory diarrhea. "
5.	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 10/30/2001 - "Recent studies indicate that the protein affected in spinal muscular atrophy, SMN, plays a role in the assembly of a number of macromolecular complexes that function in the nucleus, interacting with its partner proteins via their arginine- and glycine-rich domains."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	RNA (Ribonucleic Acid)
3.	Glycine (Aminoacetic Acid)
4.	Colloids (Colloid)
5.	Arginine (L-Arginine)
6.	Autoantibodies
7.	Inflammasomes
8.	Polysaccharides
9.	Lipids
10.	Immunoglobulins (Immunoglobulin)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Needles
3.	Ligation