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NF-kappa B (NF-kB)

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

Also Known As:

NF-kB; NF-kappaB; Nuclear Factor kappa B; Ig-EBP-1; Enhancer-Binding Protein, Immunoglobulin; Factor NF-kB, Transcription; Ig EBP 1; Immunoglobulin Enhancer Binding Protein; NF kB; NF kappaB; NF-kB, Transcription Factor; Transcription Factor NF kB; Immunoglobulin Enhancer-Binding Protein; Transcription Factor NF-kB; kappa B Enhancer Binding Protein

Networked: 11194 relevant articles (378 outcomes, 1336 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aggarwal, Bharat B: 117 articles (01/2015 - 03/2002)
2.	Sarkar, Fazlul H: 56 articles (07/2013 - 01/2002)
3.	Karin, Michael: 54 articles (01/2015 - 04/2002)
4.	Umezawa, Kazuo: 53 articles (01/2015 - 07/2002)
5.	Sethi, Gautam: 34 articles (06/2015 - 02/2006)
6.	Banerjee, Sanjeev: 33 articles (01/2011 - 09/2002)
7.	Li, Yiwei: 29 articles (07/2013 - 07/2002)
8.	Blackwell, Timothy S: 27 articles (01/2015 - 05/2002)
9.	Ahn, Kwang Seok: 26 articles (06/2015 - 11/2005)
10.	Cuzzocrea, Salvatore: 26 articles (07/2012 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2008 - "The inhibition of PC3 tumors by combined treatment correlated with significant reduction in expression of p-Akt and NF-kappaB in tumor tissue. " 01/01/2007 - "NF-kappaB plays a central role in the immune system and is described as a major actor in many of human cancers mainly because of its protective effects against apoptosis. " 08/01/1999 - "Thus, inhibiting NF-kappaB activation may sensitize cells to anticancer therapy, thereby providing a more effective treatment for certain cancers. " 11/01/2006 - "The results open new perspectives in the search for novel proapoptotic molecules effective in the treatment of cancers presenting aberrant NF-kappaB regulation." 10/30/2006 - "Since suppression of NF-kappaB has been shown to inhibit oncogenic potential of transformed cells, targeting it should be effective in the prevention and treatment of cancer."
2.	Inflammation 03/14/2005 - "NF-kappaB activation is an important event that may be involved in acute and chronic inflammation development and may contribute to self-protection against early inflammation damage. " 03/01/2009 - "Our findings project a role for p21 in the control of NF-kappaB-associated inflammation, and suggest that therapeutic modulation of p21 expression could be beneficial in inflammation-associated diseases." 04/01/2010 - "We anticipate that targeting the pathways, which facilitates CFTR's rescue to the cell surface and lipid-rafts, will not only restore CFTR channel function but also control NF-kappaB mediated chronic inflammation, although the level of correction may be a critical factor for therapeutic efficacy. " 03/21/2007 - "Thus, these stilbenoids were effective in inhibition of PGE2- or NO-mediated inflammation and NF-kappaB- or C/EBPdelta-mediated inflammatory gene expression. " 08/01/2005 - "Vectors, expressing inhibitors of signal transduction pathways involving to NF-kB and JAK-STAT-3, are effective in modulating joint inflammation in mice. "
3.	Colitis 09/15/2009 - "NF-kappaB p65siRNA shows protective effects upon the mice with DSS-induced colitis. " 09/01/2006 - "TFDG exerts protective effects in experimental colitis and inhibits production of inflammatory mediators through a mechanism that, at least in part, involves inhibition of NF-kappaB activation." 01/01/2015 - "Orally administrated Lactobacillus pentosus var. plantarum C29 ameliorates age-dependent colitis by inhibiting the nuclear factor-kappa B signaling pathway via the regulation of lipopolysaccharide production by gut microbiota." 12/01/2014 - "Rice prolamin extract ameliorates acute murine colitis by inhibiting nuclear factor-kappa B and modulating intestinal apoptosis and cell proliferation." 08/06/2014 - "This study investigated the effects of UA on nuclear factor-kappa B (NF-κB) signaling in cells and experimental murine colitis. "
4.	Sepsis (Septicemia) 01/01/2010 - "In addition, our data indicate that NF-kappaB inhibition ameliorates sepsis-induced ARF." 08/01/2009 - "While NF-kappaB inhibitors hold promise for inflammatory conditions such as sepsis, caution is necessary. " 12/15/2007 - "In conclusion, lymphocyte-directed augmentation of canonical NF-kappaB ameliorates immunosuppression during murine sepsis. " 04/01/2000 - "We postulated that early measurement of the activation of nuclear factor kappaB (NF-kappaB), a transcriptional regulatory protein involved in proinflammatory cytokine expression, may help to predict the outcome of sepsis. " 12/15/2007 - "In this study the function of canonical NF-kappaB in T cells was studied in the context of murine sepsis. "
5.	Reperfusion Injury 12/01/2005 - "The use of MMF in concert with an agent that affects NF-kappaB activation may provide even further protection against lung reperfusion injury as multiple inflammatory pathways are inhibited." 06/01/2005 - "Nuclear factor {kappa}B inactivation in the rat liver ameliorates short term total warm ischaemia/reperfusion injury." 01/01/2007 - "The present study examined the role of hepatocyte NF-kappaB activation during ischemia-reperfusion injury. " 10/01/2002 - "The present study clearly demonstrates that enhanced MCP-1 expression in rat kidney during ischemia/reperfusion injury is mediated by NF-kappaB activation and oxidative stress. " 05/01/1997 - "This study constitutes the initial demonstration that H/R activates myocardial NF kappa B and induces adaptive signal transduction against ischemia-reperfusion injury."

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Cytokines
3.	Transcription Factors (Transcription Factor)
4.	Transcription Factor AP-1 (Transcription Factor AP 1)
5.	NF-kappa B (NF-kB)
6.	Curcumin
7.	DNA (Deoxyribonucleic Acid)
8.	Small Interfering RNA (siRNA)
9.	Proteasome Endopeptidase Complex (Proteasome)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplants (Transplant)
3.	Resuscitation
4.	Oral Administration
5.	Transplantation (Transplant Recipients)