Enzymes

Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.

Also Known As:

Networked: 34502 relevant articles (744 outcomes, 3207 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sasano, Hironobu: 53 articles (11/2015 - 01/2002)
2.	Supuran, Claudiu T: 37 articles (10/2015 - 09/2003)
3.	Suzuki, Takashi: 34 articles (09/2015 - 01/2002)
4.	Sultana, Sarwat: 23 articles (01/2015 - 04/2003)
5.	Szmitkowski, Maciej: 22 articles (07/2013 - 11/2003)
6.	Gelb, Michael H: 21 articles (11/2015 - 01/2003)
7.	Zhang, Wei: 21 articles (04/2015 - 05/2006)
8.	Miki, Yasuhiro: 20 articles (09/2015 - 12/2002)
9.	Schmid-Schönbein, Geert W: 19 articles (02/2014 - 03/2002)
10.	Moriya, Takuya: 19 articles (03/2008 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 03/28/2006 - "At his most recent visit in May 2005, the patient was asymptomatic, liver enzymes were normal and the tumor was in remission on ultrasound." 03/08/2006 - "Eventually, this may help to truly individualize the dosing of this (and other) anti-cancer agent(s), using a personal genetic profile of the most relevant enzymes for every patient." 04/01/2014 - "Immunohistochemical analysis of patients' tumor samples showed low O-methyguanyl methyltransferase expression and adequate levels of mismatch repair enzymes (MLH-1, MSH-2, MSH-6, and PMS-2), which are important for the in vivo efficacy of CAPTEM. " 11/01/2008 - "Finally, the interaction between polymorphisms of genes that code for CYP2A6, CYP2A13 and other potent carcinogen-metabolizing CYP enzymes may help to determine individuals that are at higher risk of developing tumors associated with tobacco consumption." 01/01/1999 - "A knowledge of the complete sequence of events, from the gene to the outcome, would be helpful in unravelling the implications and possible preventive and treatment strategies to be employed in cases where clear associations between carcinogen-metabolizing enzymes and cancer susceptibility have been uncovered."
2.	Body Weight (Weight, Body) 11/01/2010 - "An improvement of antioxidant enzymes was associated with improved body weight control and healthier lipid profiles and therefore may play an important role in the antiobesity and hypolipidemic effects of ETJKB." 08/01/2009 - "Addition of enzymes to raw pearl-millet based diet improved the body weight gain significantly. " 10/01/2014 - "In both groups, anthropometric measurements (weight, body mass index, waist circumference), liver enzymes, and steatosis grade improved (P < 005). " 04/01/1985 - "However, the various biochemical and morphological expressions of these changes and the discrepancy between unchanged liver weight, liver:body weight ratio, liver enzymes, and the improved hepatic fat content suggest multifactorial mechanisms for TPN-related liver damage." 02/01/2015 - "There was no change in liver enzymes, body weight, or body composition during the study in either group. "
3.	Infection 06/01/2000 - "These results establish that human intestinal epithelium expresses and apically secretes SLPI, a molecule that may significantly contribute to the protection against attack from inflammatory cells and digestive enzymes, as well as against microbial infection." 06/01/1994 - "Infection of human endothelial cells by Rickettsia rickettsii causes a significant reduction in the levels of key enzymes involved in protection against oxidative injury." 01/01/2015 - "Following nanocarrier degradation by bacterial enzymes, any infection will thus emit a visible signal and be effectively treated at its source. " 01/01/2013 - "Our proteomic approach thus agreed with previously published biochemical and RT-qPCR data which reported down-regulation of scavenging enzymes and accumulation of H2O2 in recovered plants, possibly suggesting a role for this molecule in remission from infection. " 08/01/2010 - "Quorum quenching by the enzymatic inactivation of AHLs holds great promise in preventing and treating infections, and several such enzymes have been reported. "
4.	Inflammation 01/01/2015 - "Therefore, we evaluated the efficacy of a Food Supplement (FS) containing enzymes which is commonly used in various inflammatory processes and is able to modulate immune reactions during inflammation in a very rapid and efficacious way. " 10/01/2008 - "Recent studies indicate that pharmaceutical blockade of phosphoinositide 3-kinase (PI3K) signaling enzymes might be effective in reducing allergic airway inflammation. " 01/01/2003 - "This has opened the door for understanding how these enzymes are effective in inflammation. " 02/01/2010 - "Studies of Zap-70 and Itk have helped to define the potential outcomes and complications of inhibiting these enzymes in order to suppress allergic inflammation. " 04/01/2014 - "Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation."
5.	Pancreatitis 03/01/1991 - "The role of various drugs to suppress pancreatic secretion and inhibit pancreatic enzymes, although shown to be consistently effective in experimental pancreatitis, has not been established by controlled clinical trials in humans. " 06/01/1996 - "Diagnosis of acute pancreatitis (AP) has been improved in the past 15 yr as new methods for the determination of specific pancreatic enzymes have been developed. " 01/01/2013 - "It can thereby attenuate the intracellular activation of proteolytic digestive enzymes in the pancreas and reduces the severity of experimental pancreatitis when administered either intravenously or as a food supplement. " 01/01/2002 - "The findings suggest the possible roles of HSP60 and (or) HSP72 (but not that of the antioxidant enzymes) in the protection against CCK- and TC-induced acute pancreatitis. " 03/01/1995 - "Determination of serum pancreatic enzymes remains the gold standard for the diagnosis of acute pancreatitis. "

Related Drugs and Biologics

1.	Superoxide Dismutase
2.	Glutathione Peroxidase
3.	Glucose (Dextrose)
4.	Glutathione (Reduced Glutathione)
5.	Oxygen
6.	Insulin (Novolin)
7.	Catalase
8.	Aspartate Aminotransferases (Aspartate Transaminase)
9.	Antioxidants
10.	Alanine Transaminase (SGPT)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Plasma Exchange
4.	Transplantation (Transplant Recipients)
5.	Aftercare (After-Treatment)