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Cyclooxygenase Inhibitors

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Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

Also Known As:

Cyclo-Oxygenase Inhibitors; Inhibitors, Cyclo-Oxygenase; Inhibitors, Cyclooxygenase; Inhibitors, Prostaglandin Synthase; Inhibitors, Prostaglandin-Endoperoxide Synthase; Antagonists, Prostaglandin Synthesis; Cyclo Oxygenase Inhibitors; Inhibitors, Cyclo Oxygenase; Inhibitors, Prostaglandin Endoperoxide Synthase; Prostaglandin Endoperoxide Synthase Inhibitors; Prostaglandin Synthase Inhibitors; Prostaglandin Synthesis Antagonists

Networked: 424 relevant articles (32 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 56

Experts

1.	Eisenach, James C: 3 articles (01/2015 - 09/2003)
2.	Burdan, Franciszek: 3 articles (06/2012 - 11/2009)
3.	Szumiło, Justyna: 3 articles (06/2012 - 11/2009)
4.	Kumar, Anil: 3 articles (04/2011 - 12/2006)
5.	Brune, K: 3 articles (12/2009 - 08/2007)
6.	Hensley, Abigail: 2 articles (01/2015 - 08/2013)
7.	Keshavarzi, Zakieh: 2 articles (06/2014 - 09/2012)
8.	Khaksari, Mohammad: 2 articles (06/2014 - 09/2012)
9.	Geisslinger, Gerd: 2 articles (01/2013 - 04/2006)
10.	Milne, Ginger L: 2 articles (10/2012 - 06/2008)

Related Diseases

1.	Inflammation 06/01/2010 - "Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation." 02/01/2010 - "Cyclooxygenase inhibitors decrease micturition frequency in animals with bladder inflammation but to our knowledge the influence of cyclooxygenase inhibitors on detrusor overactivity has not been investigated. " 01/01/2006 - "Thus, this article provides an overview of the impact of inflammation and anti-inflammatory treatment with cyclooxygenase inhibitors on endothelial function." 10/01/2003 - "Through use of more specific cyclooxygenase inhibitors, we may be able to better understand the role of inflammation in muscle healing." 03/01/1999 - "basilicum support the dual inhibition of arachidonate metabolism as indicated by its activity in inflammation models that are insensitive to selective cyclooxygenase inhibitors. "
2.	Pain (Aches) 02/10/2010 - "Cyclooxygenase inhibitors are often prescribed to relieve severe ischemic leg pain in critical ischemic limb patients. " 05/01/2009 - "Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitors." 01/01/2008 - "The effect of three cyclo-oxygenase inhibitors on intensity of primary dysmenorrheic pain." 09/01/2003 - "Cyclooxygenase inhibitors demonstrate effective antinociception in many clinical and experimental pain models. " 12/01/2001 - "Cyclooxygenase inhibitors play primarily an adjunctive role in chronic pain treatment. "
3.	Asthma (Bronchial Asthma) 04/01/1994 - "The differing potencies of the cyclo-oxygenase inhibitors may explain the contrasting effect of these drugs in recent studies in asthma." 08/01/2003 - "This article focuses on the function of this pathway in the lung, reviews evidence implicating the involvement of this pathway in asthma and allergic airway inflammation, and discusses implications for the treatment of asthmatics with cyclooxygenase inhibitors." 11/01/1992 - "We report a case of asthma that was relieved by aspirin and other cyclooxygenase inhibitors. " 10/01/1978 - "Asthma relieved by aspirin and by other cyclo-oxygenase inhibitors." 08/01/1995 - "A very small number of patients with asthma show symptomatic improvement after administration of aspirin and other cyclooxygenase inhibitors. "
4.	Rheumatic Diseases (Rheumatism) 03/11/1998 - "Various aspects of pain in rheumatic diseases were discussed, such as physiological, neurohumoral and neurogenic mechanisms, sensory stimulation treatment, differentiation of mechanical and inflammatory pain, quality enhancement by improved cooperation between primary and tertiary care facilities, pharmacological treatment with (centrally and peripherally acting) opioids, selective cyclo-oxygenase inhibitors, and NMDA (N-methyl-D-aspartate) receptor antagonists. " 03/01/2004 - "NSAIDs or cyclooxygenase inhibitors (COX inhibitors), including aspirin, are widely used to treat pain, fever and the articular symptoms of chronic rheumatic diseases. " 05/01/1998 - "Various aspects of pain in rheumatic diseases were discussed, such as physiological, neurohumoral and neurogenic mechanisms, sensory stimulation treatment, differentiation of mechanical and inflammatory pain, quality enhancement by improved co-operation between primary and tertiary care facilities, pharmacological treatment with (centrally and peripherally acting) opioids, selective cyclo-oxygenase inhibitors, and NMDA (N-methyl-D-aspartate) receptor antagonists. "
5.	Neoplasms (Cancer) 03/01/2001 - "In contrast to anti-IL-10 treatment, application of cyclo-oxygenase inhibitors to ADJ-PC-5 tumor-bearing mice led to enhanced tumor-specific CTL responses throughout all stages of tumor progression, paralleled by retarded tumor growth and a significantly delayed onset of suppression. " 01/01/2008 - "This study evaluates HLA gene expression and tumor infiltration by B-cells, macrophages, dendritic cells, T-helper and cytotoxic T-lymphocytes in response to short-term preoperative treatment with cyclooxygenase inhibitors. " 04/01/2007 - "Cyclooxygenase inhibitors also reduced the tumor phenotype in a preliminary study. " 04/15/2008 - "Cyclooxygenase inhibitors induce apoptosis in sinonasal cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene." 07/26/2007 - "Selective cyclooxygenase inhibitors may retard the progression of cancer, but they have enhanced thrombotic potential. "

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Aspirin (Acetylsalicylic Acid)
3.	Lipoxygenase (Lipoxygenase-1)
4.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
5.	Opioid Analgesics (Opioids)
6.	N-Methylaspartate (NMDA)
7.	Ibuprofen (Motrin)
8.	Dinoprostone (PGE2)
9.	Prostaglandins
10.	Lipoxygenase Inhibitors

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Transplants (Transplant)
5.	Heterologous Transplantation (Xenotransplantation)