Arachidonate 5-Lipoxygenase (5 Lipoxygenase)

An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.

Also Known As:

5 Lipoxygenase; Arachidonate 5 Lipoxygenase; Arachidonic Acid 5-Lipoxygenase; LTA4 Synthase; Leukotriene A Synthase; Leukotriene A4 Synthase; Leukotriene A4 Synthetase; 5-Lipoxygenase, Arachidonate; 5-Lipoxygenase, Arachidonic Acid; Arachidonic Acid 5 Lipoxygenase; Synthase, LTA4; Synthase, Leukotriene A; Synthase, Leukotriene A4; Synthetase, Leukotriene A4; 5-Lipoxygenase; Arachidonate:oxygen 5-oxidoreductase

Networked: 1284 relevant articles (40 outcomes, 157 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Werz, Oliver: 33 articles (01/2024 - 08/2005)
2.	Praticò, Domenico: 20 articles (05/2023 - 04/2008)
3.	Steinhilber, Dieter: 19 articles (04/2024 - 08/2005)
4.	Rossi, Antonietta: 17 articles (01/2023 - 06/2003)
5.	Sautebin, Lidia: 16 articles (01/2019 - 06/2003)
6.	Ghosh, Jagadananda: 12 articles (01/2024 - 01/2002)
7.	Cuzzocrea, Salvatore: 10 articles (01/2007 - 06/2003)
8.	Pace, Simona: 9 articles (01/2023 - 07/2014)
9.	Peters-Golden, Marc: 9 articles (01/2020 - 01/2002)
10.	Hofmann, Bettina: 9 articles (01/2019 - 04/2009)

Related Diseases

1.	Inflammation (Inflammations) 01/15/1994 - "Inhibition of 5-lipoxygenase also reduced the severity of vascular inflammation and endothelial injury in allografts, and profoundly inhibited expression of donor MHC class II Ag on kidney cells. " 06/01/2003 - "In the present study, by comparing the responses in wild-type (WT) mice and mice lacking [knockout (KO)] the 5-lipoxygenase (5-LO), we investigated the role played by 5-LO in the development of acute inflammation. " 03/28/1997 - "In this study, we asked whether neutrophil recruitment into sites of inflammation can alter the subcellular compartmentation of 5-lipoxygenase. " 11/17/2023 - "Through network pharmacology prediction, the target of Dahuang and Baiji was identified as arachidonate 5-lipoxygenase (ALOX5), associated with inflammation. " 10/01/2022 - "These findings are indicative of a critical role of ALOX5 in myocardium healing, inflammation-resolution signaling, cardiac repair, and fibroblast pathophysiology.NEW & NOTEWORTHY Arachidonate 5-lipoxygenase (ALOX5) is critical in synthesizing specialized pro-resolving mediators that facilitate cardiac repair after cardiac injury. "
2.	Asthma (Bronchial Asthma) 03/27/1996 - "Three months of 5-lipoxygenase inhibition produced a significant improvement in asthma control. " 01/01/2014 - "Components of the 5-lipoxygenase pathway have received considerable attention as candidate drug targets resulting in one new class of medications against asthma, that is, the antileukotrienes. " 12/01/2012 - "Association of 5-lipoxygenase gene polymorphisms with bronchial asthma." 02/01/2012 - "Pharmacological intervention with 5-Lipoxygenase (5-LO) is a promising strategy for treatment of inflammatory and allergic ailments, including asthma. " 02/01/2010 - "Inhibitors of the 5-Lipoxygenase (5-LOX) pathway have a therapeutic potential in a variety of inflammatory disorders such as asthma. "
3.	Carcinogenesis 08/01/2009 - "This study aimed to investigate whether a combination of inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase, applied via a microemulsion delivery system, would be effective in topically inhibiting skin carcinogenesis. " 10/15/2004 - "Several studies suggest that there is a link between 5-lipoxygenase (5-LOX) and carcinogenesis in humans and animals. " 08/01/1998 - "These studies suggest that inhibitors of 5-lipoxygenase may have benefits as preventive agents of lung tumorigenesis." 05/01/2024 - "The role of human 5-Lipoxygenase (5-LO) in carcinogenesis - a question of canonical and non-canonical functions." 05/01/2013 - "Overexpression of 5-lipoxygenase and its relation with cell proliferation and angiogenesis in 7,12-dimethylbenz(α)anthracene-induced rat mammary carcinogenesis."
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/1986 - "The results of our study support the view that abnormal 5-lipoxygenase activity is present in psoriasis. " 01/01/1993 - "5-Lipoxygenase activation in psoriasis: a dead issue?" 01/01/1986 - "The reported increase in activity of the circulating PMNL in psoriasis does not appear to be due to increased 5-lipoxygenase activity in these cells." 06/01/1985 - "We conclude that in psoriasis there is no enhanced activity of the 5-lipoxygenase pathway in circulating polymorphonuclear leukocytes." 06/01/1985 - "Polymorphonuclear leukocyte 5-lipoxygenase activity in psoriasis."
5.	Infections 03/01/2015 - "5-Lipoxygenase negatively regulates Th1 response during Brucella abortus infection in mice." 02/15/2013 - "Animals lacking 5-lipoxygenase were significantly more vulnerable to intrauterine GAS infection than were wild-type mice and showed enhanced dissemination of bacteria out of the uterus and a more robust inflammatory response than did wild-type mice. " 01/01/2013 - "To determine the involvement of LTs in the host response to pulmonary infection, wild-type and LT-deficient mice by targeted disruption of the 5-lipoxygenase gene (knockout mice) were studied following intratracheal challenge with P. " 02/10/2011 - "5-Lipoxygenase (5-LOX) plays key roles in infection and allergic responses. " 12/15/1996 - "To determine the role of endogenous LTs in the host response to pulmonary infection, wild-type mice and mice rendered LT-deficient by targeted disruption of the 5-lipoxygenase gene (knockout mice) were studied following intratracheal challenge with Klebsiella pneumoniae. "

Related Drugs and Biologics

1.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
2.	Proteins (Proteins, Gene)
3.	Cyclooxygenase Inhibitors
4.	Enzymes
5.	Arachidonic Acid (Vitamin F)
6.	Cyclooxygenase 2 (Cyclooxygenase-2)
7.	Leukotriene B4
8.	zileuton (Zyflo)
9.	Lipoxygenase Inhibitors
10.	MK-886

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Therapeutics
4.	Chemoprevention
5.	Microspheres (Microsphere)