Asthma (Bronchial Asthma)

A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Also Known As:
Bronchial Asthma; Asthmas; Asthma, Bronchial
Networked: 51179 relevant articles (3993 outcomes, 8786 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Rhinitis
2. Inflammation
3. Chronic Obstructive Pulmonary Disease (COPD)
4. Hypersensitivity (Allergy)
5. Asthma (Bronchial Asthma)


1. Barnes, Peter J: 130 articles (10/2015 - 01/2002)
2. Park, Choon-Sik: 124 articles (07/2015 - 06/2003)
3. Weiss, Scott T: 123 articles (12/2015 - 03/2002)
4. Szefler, Stanley J: 109 articles (12/2015 - 01/2002)
5. Busse, William W: 97 articles (12/2015 - 04/2002)
6. Postma, Dirkje S: 96 articles (09/2015 - 01/2002)
7. Boulet, Louis-Philippe: 91 articles (01/2016 - 08/2002)
8. Park, Hae-Sim: 90 articles (03/2015 - 05/2002)
9. O'Byrne, Paul M: 88 articles (12/2015 - 02/2002)
10. Holgate, Stephen T: 82 articles (12/2015 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Asthma:
1. Adrenal Cortex Hormones (Corticosteroids)IBA
08/01/2003 - "The significant findings of 17 selected, controlled clinical trials of oral corticosteroids (OCSs) for acute exacerbations of asthma in children, compared with placebo or with other formulations of corticosteroids, can be summarized as follows: 1) OCSs are effective for the outpatient treatment of acute asthma, 2) pulmonary function tests may not be the best means of assessing the efficacy of OCSs for acute asthma, 3) early administration of OCSs for acute asthma reduces hospitalizations, 4) the critical factor for a positive outcome is early administration of the corticosteroid, and 5) OCSs are preferred for the outpatient treatment of acute asthma. "
10/01/1998 - "This study aimed to determine whether the changes in practice in the management of asthma since the early 1980s have improved standards (as assessed by higher actual/best function) and reduced the need for oral corticosteroids. "
11/01/2015 - "Combined inhaled corticosteroids and long-acting β-agonists treatments are most effective for preventing exacerbations among paediatric asthma patients. "
09/12/2015 - "Current therapies based on inhaled corticosteroids and longacting β2 agonists are effective in controlling asthma in most, but not all patients, with a few patients falling into the severe asthma category. "
01/01/2015 - "A previous history of asthma, smoking, and not fully reversible airflow limitation are considered the main characteristics of ACOS, with the most accepted first-line treatment being long-acting β2-agonist/inhaled corticosteroids."
2. Budesonide (Pulmicort)FDA LinkGeneric
3. Albuterol (Salbutamol)FDA LinkGeneric
4. omalizumab (Xolair)FDA Link
5. montelukast (Singulair)FDA Link
6. fluticasone (Cutivate)FDA LinkGeneric
7. salmeterol (Serevent)FDA Link
8. formoterol (Oxis)FDA Link
9. Immunoglobulin E (IgE)IBA
03/01/1999 - "This study suggests that (1) the percentage of CD4+, CD8+, or IL-2R+ lymphocytes in peripheral blood was significantly elevated during acute attacks and returned to normal ranges after complete remission was achieved; (2) plasma soluble IL-2R is a sensitive marker for asthma activity; and (3) atopic asthmatic children seem to have a hereditary predisposition of having higher levels of soluble IL-2R in asthma attacks, coinherited with the trait of IgE."
09/01/2015 - "This paper describes a patient with severe asthma and IBS where the administration of an anti-Immunoglobulin E (IgE) monoclonal antibody not only improved her asthma but also resulted in an almost complete resolution of her IBS symptoms. "
01/01/2012 - "Blood immunoglobulin E levels were significantly increased in the asthma group, and blood eosinophils were significantly elevated in the complete asthma remission, symptomatic remission and asthma groups compared with controls. "
12/01/2006 - "Skin tests are considered the gold standard for detecting allergen-specific immunoglobulin E (IgE) in the clinical setting and are an important tool for diagnosing and managing allergic asthma. "
07/01/2000 - "I have three objectives: (1) review T cell differentiation leading to the Th1/Th2 paradigm; (2) evaluate the increased prevalence of atopy, including asthma, as a consequence of a Th2-dominated immune system; (3) relate the high prevalence of asthma in inner city United States black children to the relatively recent migration of their ancestors from tropical regions of Africa, where genetically biased Th2-dependent IgE responses may be important in protection against high burdens of parasitic worms."
10. Theophylline (Theon)FDA LinkGeneric

Therapies and Procedures

1. Immunotherapy
2. Nebulizers and Vaporizers (Inhaler)
3. Metered Dose Inhalers (Metered Dose Inhaler)
4. Drug Therapy (Chemotherapy)
5. Aftercare (After-Treatment)