Prostaglandins

A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.

Also Known As:

Networked: 6793 relevant articles (149 outcomes, 557 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Narumiya, Shuh: 25 articles (01/2014 - 04/2002)
2.	Pérez-Sala, Dolores: 10 articles (10/2014 - 11/2002)
3.	Fernández, Nuria: 9 articles (11/2006 - 12/2002)
4.	Monge, Luis: 9 articles (11/2006 - 12/2002)
5.	Diéguez, Godofredo: 9 articles (11/2006 - 12/2002)
6.	Serhan, Charles N: 8 articles (09/2015 - 09/2002)
7.	Ben-Eliyahu, Shamgar: 8 articles (03/2013 - 08/2002)
8.	Basu, Samar: 7 articles (01/2015 - 07/2003)
9.	Sugimoto, Yukihiko: 7 articles (12/2014 - 04/2002)
10.	Fischer, Susan M: 7 articles (11/2014 - 01/2002)

Related Diseases

1.	Inflammation 11/01/2002 - "In addition to their proinflammatory activities, prostaglandins recently have been shown to be beneficial in the resolution of tissue injury and inflammation. " 05/01/2011 - "Despite the clinical efficacy of nonsteroidal antiinflammatory drugs, prostaglandins may function in both the promotion and resolution of inflammation. " 09/01/2015 - "Although many studies have identified their roles in inflammation, regulatory functions of prostanoids in angiogenesis are poorly understood. " 11/01/2013 - "This study aims to evaluate the effect of prostaglandins isolated from soft coral Plexaura homomalla, collected in Colombian Caribbean Sea, on in vivo and in vitro inflammation models. " 06/01/2012 - "Prostaglandins (PGs) are well established as mediators of acute inflammation, and recent studies in experimental animals have provided evidence that they also function in transition to and maintenance of chronic inflammation. "
2.	Ulcer 03/01/2014 - "- Arterial ulcers: Prostanoids and spinal cord stimulation may be effective in healing ischemic ulcers. " 09/15/2014 - "Clinical studies indicate that prostaglandins of E class (PGEs) may promote healing of tissue injury e.g., gastroduodenal and dermal ulcers. " 01/01/1994 - "Metaanalyses of therapeutic trials have indicated that time to first relapse was longer after ulcer healing with prostaglandins (PG) than after healing with H2-receptor blockers, which might be due to a different effect of the two treatments on parietal cell sensitivity. " 12/01/1992 - "Although studies continue to demonstrate the benefit of intravenous prostaglandins in the treatment of Raynaud's phenomenon and digital ulcers in scleroderma, an initial report of oral prostaglandins was disappointing. " 12/01/1990 - "The mechanism of ulcer healing by prostaglandins and the clinical relevance of antiulcer effects of drugs demonstrated in acute studies with animals were also controversial. "
3.	Neoplasms (Cancer) 08/15/2001 - "The present study examined the role of endogenous prostaglandins in the proliferation/survival, the migratory and invasive behavior and angiogenic ability of a highly metastatic murine mammary tumor cell line, C3L5, originally derived from a C3H/HeJ spontaneous mammary tumor. " 09/01/2000 - "This study suggests that prostaglandins may have a negligible net effect on NK activity associated with rat liver, and may be unlikely to mediate cancer-related immune function." 07/01/1991 - "Several studies have correlated the excessive production of prostaglandins (PGs) with tumor promotion and the suppression of the immune response. " 01/01/1986 - "The murine tumor cells used in this study produced high levels of prostaglandins. " 10/01/1985 - "In the current study it was observed that cancer patients have increased monocyte suppressor cell activity that is mediated by prostaglandins and contributes to the depressed proliferative response of the patients' T-cells. "
4.	Hypertension (High Blood Pressure) 09/01/1982 - "Hypertension and beneficial treatment with beta-blocking agents does not change the platelet sensitivity to the antiaggregatory prostaglandins." 03/01/1984 - "Results of in vitro studies performed in different laboratories have led to the hypothesis that in spontaneously hypertensive rats (SHR), the biosynthesis of the vasodilator prostaglandins (PG) I2 and E2 increases secondarily to the rise in the arterial pressure, as a protective mechanism for reducing the severity of hypertension. " 06/01/2007 - "This characteristic lymphatic hypertension may be improved by complex physiotherapy or local application of prostaglandins. " 08/01/2011 - "The aim of our study was to evaluate the contribution of endogenous vasodilator prostanoids, Ca(2+)-activated K(+) channels and NO to blood pressure (BP) maintenance in rats with three different forms of experimental hypertension. " 01/01/2004 - "This first study on the role of renal COX-2 in TGR also demonstrates that COX-2-derived vasodilatory prostanoids do not act as renal compensatory vasodilator and natriuretic substances in this model of hypertension."
5.	Pain (Aches) 11/01/1999 - "This study confirms that COX-2 derived prostanoids are important clinical mediators of pain and other symptoms of knee OA and that inhibition of COX-1 is not required to provide clinical benefit." 06/01/1983 - "It is suggested on the basis of animal studies that this effect may be mediated by release of prostaglandins as well as indirectly via pain relief." 07/01/2013 - "Here, we summarize the current knowledge on the roles of individual prostanoids in modulating inflammatory pain. " 07/01/2013 - "Prostanoids and inflammatory pain." 06/01/2013 - "Recent in-vitro/in-vivo data demonstrated presence and action of prostaglandins within the trigeminal pain pathways. "

Related Drugs and Biologics

1.	Leukotrienes
2.	Dinoprostone (PGE2)
3.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
4.	Alprostadil (Muse)
5.	Epoprostenol (Prostacyclin)
6.	Aspirin (Acetylsalicylic Acid)
7.	Iloprost (Ventavis)
8.	Nitric Oxide (Nitrogen Monoxide)
9.	Indomethacin (Indometacin)
10.	Dinoprost

Related Therapies and Procedures

1.	Amputation
2.	Injections
3.	Ligation
4.	Analgesia
5.	Liver Transplantation