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Ibuprofen (Motrin)

A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Also Known As:

Motrin; Nuprin; Rufen; Brufen; IP-82; Ibumetin; Ibuprofen I.V. Solution; Ibuprofen, (+-)-Isomer; Ibuprofen, (R)-Isomer; Ibuprofen, (S)-Isomer; Ibuprofen, Aluminum Salt; Ibuprofen, Calcium Salt; Ibuprofen, Copper (2+) Salt; Ibuprofen, Magnesium Salt; Ibuprofen, Potassium Salt; Ibuprofen, Sodium Salt; Ibuprofen, Zinc Salt; Ibuprofen-Zinc; Salprofen; Trauma-Dolgit Gel; alpha-Methyl-4-(2-methylpropyl)benzeneacetic Acid; Aluminum Salt Ibuprofen; Calcium Salt Ibuprofen; I.V. Solution, Ibuprofen; IP 82; IP82; Ibuprofen Zinc; Magnesium Salt Ibuprofen; Potassium Salt Ibuprofen; Salt Ibuprofen, Magnesium; Salt Ibuprofen, Sodium; Salt Ibuprofen, Zinc; Sodium Salt Ibuprofen; Trauma Dolgit Gel; TraumaDolgit Gel; Zinc Salt Ibuprofen; Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-

Networked: 3360 relevant articles (464 outcomes, 767 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Carboxylic Acids: 83
  - Carbocyclic Acids
    - Phenylpropionates
      - Ibuprofen: 3360
        dexibuprofen: 22
        ibuprofen arginine: 17
        solufenum: 4
        2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester: 3
        metoxibutropate: 3
        ibuprofen drug combination hydrocodone tartrate: 2
        ibuprofen drug combination oxycodone hydrochloride: 1
        ibuprofen-N-decyl-pyridostigmine: 1
        ibuprofen-N-octyl-pyridostigmine: 1
        L 5409709: 1
        Myprodol: 1
        pimeprofen: 1
        2-(4'-isobutylphenyl)propionitrile
        2-(4-dimethylvinylphenyl)propionic acid
        2-(4-hydroxyethoxyphenyl)propionic acid
        2-mercaptoethylibuprofenate
        6-isobutyl alpha-methyl-3-pyridineacetic acid
        carboxyibuprofen
        cholesteryl ibuprofen
        dextran ibuprofen ester
        hydroxyibuprofen
        ibuprofen acyl glucuronide
        ibuprofen diethylaminoethyl ester
        ibuprofen dimethyl aminoethanol octyl
        ibuprofen-S-acyl-glutathione
        imidazolium ibuprofenate
        Poly-5

Experts

1.	Moore, R Andrew: 23 articles (01/2015 - 02/2002)
2.	Derry, Sheena: 19 articles (01/2015 - 04/2006)
3.	Erdeve, Omer: 12 articles (03/2014 - 09/2008)
4.	McQuay, Henry J: 11 articles (05/2011 - 02/2002)
5.	Dilmen, Ugur: 10 articles (03/2014 - 04/2009)
6.	Rigas, Basil: 9 articles (12/2014 - 12/2002)
7.	Gitton, Xavier: 8 articles (08/2008 - 08/2004)
8.	Moore, R A: 7 articles (10/2015 - 01/2000)
9.	Altug, Nahide: 7 articles (03/2014 - 04/2009)
10.	Uras, Nurdan: 7 articles (03/2014 - 04/2011)

Related Diseases

1.	Pain (Aches) 07/01/2001 - "Ibuprofen, 200 mg and 400 mg, were statistically significantly more effective than placebo for all clinically important secondary pain relief outcomes. " 01/01/2013 - "For 400 mg ibuprofen, the incidence of confirmed perceptible pain relief was significantly greater vs. placebo at 20 min post dosing (both studies). " 03/01/2001 - "Over the 2 days of treatment, the heated patch plus placebo tablet group (mean 3.27, P <.001), the unheated patch plus ibuprofen group (mean 3.07, P =.001), and the combination heated patch plus ibuprofen group (mean 3.55, P <.001) had significantly greater pain relief than the unheated patch plus placebo group (mean 1.95). " 06/01/1999 - "Patients receiving ibuprofen showed significant improvement in WOMAC pain, physical functioning, and the total score, while improvement was detected only for bodily pain on the SF-36. " 09/01/1994 - "Patients using the topical ibuprofen cream had significant reduction in pain scores over the first 48 h of treatment."
2.	Fever (Fevers) 01/01/2011 - "The difference in antipyretic efficacy of ibuprofen in the high fever group was statistically significant in the 3rd and 4th hours, and in the low-grade fever group, in the 3rd hour after medication. " 11/01/1998 - "A significant reduction in temperature (0.7 degrees C) after fever onset in the ibuprofen group compared with the placebo group was demonstrated if all 555 fever episodes were considered. " 01/01/2008 - "Ibuprofen is effective in reducing the time with fever. " 11/01/2000 - "Ibuprofen is effective in the treatment of fever in children. " 11/01/2000 - "Both ibuprofen formulations were effective in reducing fever and may be considered clinically bioequivalent."
3.	Postoperative Pain 05/01/2010 - "Good evidence supports ibuprofen as an effective and safe analgesic for postoperative pain." 01/01/2009 - "This review updates a 1999 Cochrane review showing that ibuprofen at various doses was effective in postoperative pain in single dose studies designed to demonstrate analgesic efficacy. " 09/01/2009 - "These findings suggest that ibuprofen 800 mg IV q6h was effective for postoperative pain management and was generally well tolerated. " 11/01/2002 - "There is no clinically meaningful difference in the efficacy of ibuprofen 400 mg between men and women experiencing moderate to severe postoperative pain and women were well represented." 11/01/1992 - "The purpose of the present study was to compare the efficacy of medicating with ibuprofen immediately presurgically to medicating immediately postsurgically on postoperative pain associated with periodontal surgery. "
4.	Osteoarthritis 07/01/2014 - "Although anti-inflammatory doses of ibuprofen are very effective in treating the signs and symptoms of osteoarthritis (OA), they come with an increased risk for gastrointestinal damage which can limit their use and decrease patient adherence to therapy. " 01/01/1996 - "In conclusion, although both NSAID treatments improved the clinical condition of patients with painful osteoarthritis, statistically significant differences in favour of once-daily s-r ibuprofen (1600 mg) were demonstrated in terms of efficacy, indicating a potential therapeutic advantage for this formulation. " 11/01/2013 - "Investigate the safety and efficacy of a novel transdermal ibuprofen formulation (VALE®-ibuprofen) containing 10% ibuprofen, compared to a placebo in a randomized, double-blinded clinical trial, for clinical improvement in patients with moderate to severe painful osteoarthritis of the knee. " 01/01/2013 - " evidence from a single study of 174 people with hand osteoarthritis indicated that treatment with Arnica extract gel probably results in similar benefits as treatment with ibuprofen (non-steroidal anti-inflammatory drug) with a similar number of adverse events. " 07/13/1984 - "A review of 28 clinical trials involving ibuprofen for osteoarthritis shows sometimes conflicting results in efficacy, often because of inadequacies in study design or dosage. "
5.	Patent Ductus Arteriosus 01/01/2013 - "There are few published reports concerning the efficacy of oral ibuprofen for the treatment of patent ductus arteriosus (PDA) in extremely low birth weight (ELBW) infants. " 05/01/2000 - "This study was aimed at evaluating the efficacy of ibuprofen in the prophylaxis of patent ductus arteriosus (PDA) in very preterm neonates and at detecting eventual side-effects. " 04/01/2012 - "Improved closure of patent ductus arteriosus with high doses of ibuprofen." 04/01/2012 - "Our aim was to assess the hypothesis that a high-dose regimen of ibuprofen is more effective than the standard-dose regimen in closing patent ductus arteriosus (PDA) without increasing adverse effects. " 11/01/2012 - "Repeated courses of ibuprofen are effective in closure of a patent ductus arteriosus."

Related Drugs and Biologics

1.	Acetaminophen (Paracetamol)
2.	Naproxen (Naprosyn)
3.	Aspirin (Acetylsalicylic Acid)
4.	Indomethacin (Indometacin)
5.	Diclofenac (SR 38)
6.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
7.	Codeine (Codeine Phosphate)
8.	Ketoprofen (Orudis)
9.	Sodium
10.	celecoxib (Celebrex)

Related Therapies and Procedures

1.	Analgesia
2.	Episiotomy
3.	Tonsillectomy
4.	Oral Surgery (Maxillofacial Surgery)
5.	Tooth Extraction (Tooth Extractions)