Indomethacin (Indometacin)

A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.

Also Known As:

Networked: 7863 relevant articles (590 outcomes, 958 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Suleyman, Halis: 18 articles (02/2015 - 06/2003)
2.	Lundholm, Kent: 13 articles (12/2014 - 03/2004)
3.	Halici, Zekai: 13 articles (01/2012 - 11/2004)
4.	Goadsby, Peter J: 12 articles (01/2015 - 09/2004)
5.	Prakash, Sanjay: 12 articles (04/2014 - 07/2008)
6.	Yoshikawa, Toshikazu: 12 articles (02/2014 - 01/2006)
7.	Takagi, Tomohisa: 12 articles (02/2014 - 01/2006)
8.	Naito, Yuji: 12 articles (02/2014 - 01/2006)
9.	Takeuchi, Koji: 12 articles (10/2013 - 01/2002)
10.	Cadirci, Elif: 11 articles (11/2015 - 05/2007)

Related Diseases

1.	Pain (Aches) 01/01/1983 - "Both treatments produced marked improvement in pain and the other variables studied but, apart from blood pressure which was raised in the indomethacin group, no significant differences between treatments were observed. " 04/01/1998 - "As good pain relief facilitates post-operative ocular examination, as well as patient comfort and recovery, the authors designed a prospective randomised double masked trial to evaluate the efficacy of indomethacin as a satisfactory analgesic for such patients. " 08/01/2009 - "Physical functioning, physical role, bodily pain, general health, vitality, social functioning, grip strength, duration of morning stiffness improved significantly better in the combination group compared to indomethacin only group. " 10/01/1995 - "Rectal indomethacin use following caesarean delivery leads to significantly improved pain relief compared with placebo. " 11/05/1983 - "Pain on movement was significantly increased, and indomethacin was more effective in reducing this than cryoanalgesia. "
2.	Ulcer 11/01/1986 - "These compounds, as well as the 7-(2-chloropropionyl) derivative 2d, also exhibited antiinflammatory activity; in addition, 2c,d were highly effective in inhibiting indomethacin-induced ulcers in the rat." 02/01/1993 - "After a 2-week treatment with indomethacin, a histological study of the ulcers showed that the length of rupturing of the muscularis mucosa was significantly greater than that observed in the control group. " 01/01/2015 - "Results indicate absence of ulcers and significantly higher and prolonged anti-inflammatory efficacy for formulations F1 and F2, with carrier: coat ratio, 5:1 and drug loads of 20 and 40 %, respectively, compared with standard oral indomethacin. " 01/01/2015 - "Animals pretreated with GC extract showed a significant reduction in ulcer score, ulcer index, gastric volume, and gastric total acidity in indomethacin-induced ulcer models in a dose dependent manner when compared to the ulcerated control group. " 11/01/2004 - "It also afforded significant protection against alcohol and indomethacin induced ulcer as well as stress induced ulceration. "
3.	Neoplasms (Cancer) 01/01/1997 - "Indomethacin-treated P815 cells were observed to be less effective in inhibiting nitrite production of macrophages compared to untreated tumor cells. " 04/15/2008 - "In conclusion, indomethacin exerts proapoptotic and antitumorigenic effects in sinonasal cancer cells through the induction of NAG-1 and can be considered a safe and effective chemopreventive agent against sinonasal cancer." 07/01/2005 - "Expression of EP1 in the liver and EP4 receptor in white adipose tissue were upregulated and responded to indomethacin treatment, while downregulated expression of EP3 in skeletal muscle from tumor-bearing mice was unresponsive to indomethacin treatment despite improved carcass weight. " 03/01/2005 - "By contrast, indomethacin improved body composition similar in EP1 and EP3 knockouts as well as in wild type tumor-bearing animals and tumor growth was retarded in EP1 and promoted in EP3 knock outs. " 01/01/1992 - "The concomitant administration of indomethacin during chemoradiation therapy improved subjective status of patients and tumor response but failed to increase survival."
4.	Patent Ductus Arteriosus 06/01/1988 - "Indomethacin has proven effective in closing the patent ductus arteriosus (PDA) in most low birth weight (LBW) neonates with this disorder. " 04/01/2013 - "After the introduction of a new protocol based on the early treatment with indomethacin for patent ductus arteriosus, the objective of this study was to assess the safety and efficacy of this new practice in comparison with the safety and efficacy of the conventional treatment in a high-risk population. " 04/01/2004 - "Is oral indomethacin effective in treatment of preterm infants with patent ductus arteriosus?" 11/01/1998 - "Postnatally, therapeutic indomethacin administration is usually effective in mediating patent ductus arteriosus (PDA) constriction in premature infants. " 09/01/1993 - "Indomethacin has been demonstrated to be effective for closure of hemodynamically symptomatic patent ductus arteriosus (PDA) in premature infants. "
5.	Inflammation 06/01/2005 - "Despite hederasaponin-C and -E were found effective in the second phase of inflammation, they were not found as effective as indomethacin and hederacolchiside-F. " 03/14/2013 - "Preliminary DNP experiments with the glass-forming anti-inflammation drug, indomethacin, showed promising results, and further studies are underway to prepare DNP samples using pharmaceutical techniques." 01/01/2013 - "Emu oil reduces small intestinal inflammation in the absence of clinical improvement in a rat model of indomethacin-induced enteropathy." 05/01/2015 - "Moreover, histopathological studies indicated that EA significantly diminished migration of polymorphonuclear leukocytes into site of inflammation, as did indomethacin. " 01/01/2015 - "The effects of Syzygium cumini (L.) Skeels aqueous extract (SCC) on antifree radical, anti-inflammation, and antiulcer of SCC on indomethacin induced acute gastric ulceration were determined in our study. "

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3.	Diclofenac (SR 38)
4.	Naproxen (Naprosyn)
5.	Dinoprostone (PGE2)
6.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
7.	Ethanol (Ethyl Alcohol)
8.	Dexamethasone (Maxidex)
9.	Flurbiprofen (Froben)
10.	Piroxicam (Feldene)

Related Therapies and Procedures

1.	Arthroplasty
2.	Oral Administration
3.	Radiotherapy
4.	Ligation
5.	Immunotherapy