HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)

Subscribe to New Research on Prostaglandin-Endoperoxide Synthases

Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.

Also Known As:

Cyclooxygenase; Cyclo-Oxygenase; Prostaglandin-Endoperoxide Synthase; Arachidonic Acid Cyclooxygenase; Cyclooxygenases; Hydroperoxide Cyclase; PGH2 Synthetase; Prostaglandin Cyclo-Oxygenase; Prostaglandin Cyclooxygenase; Prostaglandin Endoperoxide Synthetase; Prostaglandin G-H Synthase; Prostaglandin H2 Synthetase; Prostaglandin Synthetase; Cyclase, Hydroperoxide; Cyclo Oxygenase; Cyclo-Oxygenase, Fatty Acid; Cyclo-Oxygenase, Prostaglandin; Cyclooxygenase, Arachidonic Acid; Cyclooxygenase, Prostaglandin; Endoperoxide Synthetase, Prostaglandin; Fatty Acid Cyclo Oxygenase; G-H Synthase, Prostaglandin; Prostaglandin Cyclo Oxygenase; Prostaglandin Endoperoxide Synthases; Prostaglandin G H Synthase; Synthase, PGH; Synthase, Prostaglandin; Synthase, Prostaglandin G-H; Synthase, Prostaglandin H; Synthase, Prostaglandin-Endoperoxide; Synthases, Prostaglandin-Endoperoxide; Synthetase, PGH2; Synthetase, Prostaglandin; Synthetase, Prostaglandin Endoperoxide; Synthetase, Prostaglandin H2; Fatty Acid Cyclo-Oxygenase; PGH Synthase; Prostaglandin H Synthase; Prostaglandin Synthase; (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase

Networked: 5248 relevant articles (177 outcomes, 593 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - Oxygenases: 89
      - Mixed Function Oxygenases: 449
        Prostaglandin-Endoperoxide Synthases: 5248
        cyclooxygenase-3: 1
        rat Ptges protein
  - Multienzyme Complexes: 7
    - Prostaglandin-Endoperoxide Synthases: 5248

Experts

1.	Konturek, S J: 19 articles (06/2011 - 09/2000)
2.	Konturek, P C: 17 articles (11/2006 - 09/2000)
3.	DuBois, Raymond N: 14 articles (12/2015 - 03/2003)
4.	Basu, Samar: 13 articles (01/2015 - 07/2003)
5.	Nair, Muraleedharan G: 13 articles (03/2013 - 01/2003)
6.	Kulkarni, Shrinivas K: 13 articles (01/2008 - 06/2002)
7.	Geisslinger, Gerd: 12 articles (11/2014 - 03/2003)
8.	Brzozowski, T: 12 articles (06/2011 - 10/2000)
9.	Dannenberg, Andrew J: 11 articles (10/2013 - 01/2002)
10.	Laufer, Stefan: 11 articles (08/2012 - 03/2002)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2006 - "There is controversy on the safety of inhibitors of cyclooxygenase administered at high doses; however, these drugs have been reported to be effective in the prevention of a variety of human cancers. " 10/15/2002 - "A number of studies have shown that cyclooxygenase (COX)-2 is overexpressed in many forms of human tumors, suggesting that COX-2 inhibition may be useful in the treatment of cancer. " 04/01/2009 - "Cyclooxygenase (COX)-2 inhibitors have demonstrated efficacy in reducing cancer risk in animal and human studies. " 03/01/2004 - "Accordingly, observations in animal experiments and short-term clinical trials in selected groups of cancer patients, have implied that cyclo-oxygenase (COX) blockade can improve host metabolism and well-being, and long-term COX-treatment of unselected groups have implied improved survival. " 10/01/2005 - "Cyclooxygenase (COX) inhibitors have demonstrated efficacy in models of human cancer but the relevant mechanisms have not all been elucidated. "
2.	Pain (Aches) 07/01/2006 - "Selective inhibition of the cyclooxygenase (COX)-2 enzyme appeared to offer patients similar pain relief with an improved adverse-effect profile. " 05/01/2010 - "These data suggest a more limited role for spinal cord cyclooxygenase in human pain states than predicted by studies in animals." 04/01/2009 - "[Modulation of cortical pain processing by cyclooxygenase inhibition: a functional MRI study]." 09/01/2007 - "Brain imaging of analgesic and antihyperalgesic effects of cyclooxygenase inhibition in an experimental human pain model: a functional MRI study." 08/01/2015 - "These drugs exert their effect by inhibiting the enzyme cyclooxygenase (COX) and are commonly used for the management of pain after endodontic treatment. "
3.	Inflammation 09/01/1992 - "The study suggests that long-term cyclooxygenase inhibition offers protection against hemodynamic and metabolic changes in juxta-articular bone secondary to synovial inflammation." 06/01/2010 - "As adjuvant during sensitization may cause unspecific immune reactions, the aim of the present study was to define the role of cyclooxygenase (COX) activity on airway inflammation and airway hyperresponsiveness (AHR) in an adjuvant-free allergic mouse model. " 02/01/2010 - "The aim of this study was to investigate the effect of a cyclooxygenase (COX)-2 inhibitor on the recovery of muscle function, inflammation, regeneration after, and adaptation to, unaccustomed eccentric exercise. " 07/01/2009 - "The aim of the current study was to define how cyclooxygenase (COX)-activity affects airway hyperresponsiveness (AHR) and inflammation using interventions with COX inhibitors at different time points during allergen challenge and/or prior to measurement of AHR in an eosinophil-driven allergic mouse model. " 10/15/2008 - "Our previous studies demonstrate that the cyclooxygenase (COX) metabolic pathway is actively involved in allergic responses and COX inhibition increases allergic airway inflammation in a STAT6-independent fashion. "
4.	Ischemia 01/01/2006 - "The aim of this study was to assess cyclooxygenase (COX)-1 and COX-2 expression in skeletal muscle after an ischemia-reperfusion (I/R). " 11/13/2001 - "The purpose of this study was to examine the effects of cyclooxygenase (COX) deficiency on baseline functional characteristics and on recovery of left ventricular developed pressure (LVDP) after 20 minutes of global ischemia and 40 minutes of reperfusion in untreated and preconditioned hearts. " 11/01/1999 - "The aim of this study was to assess whether cyclooxygenase (COX) inhibitors protect the endothelial function against the deleterious effect of ischemia and reperfusion. " 01/01/2012 - "Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia." 05/01/2011 - "Expression of cyclooxygenase genes in the jejunum of horses during low-flow ischemia and reperfusion."
5.	Osteoarthritis 08/15/2005 - "Need for common internal controls when assessing the relative efficacy of pharmacologic agents using a meta-analytic approach: case study of cyclooxygenase 2-selective inhibitors for the treatment of osteoarthritis." 11/01/2003 - "Comparing the efficacy of cyclooxygenase 2-specific inhibitors in treating osteoarthritis: appropriate trial design considerations and results of a randomized, placebo-controlled trial." 01/01/2011 - "[Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part II]." 01/01/2011 - "[Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part I]." 12/01/1999 - "To compare prostaglandin production and cyclooxygenase activity in high-density primary cultures of chondrocytes from patients with osteoarthritis and from healthy controls. "

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
3.	Lipoxygenase (Lipoxygenase-1)
4.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
5.	Arachidonic Acid (Vitamin F)
6.	Aspirin (Acetylsalicylic Acid)
7.	celecoxib (Celebrex)
8.	Dinoprostone (PGE2)
9.	Prostaglandins
10.	Protein Isoforms (Isoforms)

Related Therapies and Procedures

1.	Analgesia
2.	Oral Administration
3.	Ligation
4.	Therapeutics
5.	Prostatectomy (Retropubic Prostatectomy)