Opioid Analgesics (Opioids)

08/18/2015 - "However, close reading of the primary literature supports a different conclusion: opioids have been shown in randomized controlled trials (RCTs) to be highly effective in the treatment of chronic nonmalignant pain; long-term follow-up studies have shown that this effectiveness can be maintained; and effectiveness has been limited in many clinical trials by failure to take into account high variability in dose requirements, failure to adequately treat depression, and use of suboptimal outcome measures. "
05/01/2015 - "This study of patients with chronic spine pain was conducted to test the hypothesis that decreasing pain through interventional techniques coupled with cognitive motivational counseling can be highly effective in reducing chronic pain interference, reliance on prescription opioids, and enhancing overall function and quality of life. "
09/30/2014 - "The objectives of the article are to review the following: (1) the key initiating causes of the epidemic; (2) the evidence for safety and effectiveness of opioids for chronic pain; (3) federal and state policy responses; and (4) recommendations for neurologists in practice to increase use of best practices/universal precautions most likely to improve effective and safe use of opioids and to reduce the likelihood of severe adverse and overdose events. "
11/01/2012 - "Opioids are an extremely important part of medical practice, and for thousands of years, continued to provide relief from severe acute and chronic pain. "
01/01/2004 - "Opioid analgesics are highly effective for treating many forms of acute and chronic pain. "

05/01/2004 - "However, these guidelines can be questioned with regard to the extent of efficacy as well as the rationale for not using strong opioids as first-line treatment, especially in terminal cancer patients. "
04/01/2014 - "It was notable that 66% of the physicians had seen cancer patients in the last 12 months and 63% had seen patients with advanced stage cancer where opioids are considered as the mainstay of treatment. "
11/27/1999 - "There is evidence that systemically administered opioids are effective in alleviating breathlessness in patients with cancer."
05/01/1994 - "This article describes our experience in the clinical use of nebulized opioids for the management of dyspnoea in patients with terminal cancer by reviewing three specific patient case studies in which this treatment was found to be both safe and effective in controlling breathlessness. "
02/01/2014 - "For the growing number of cancer survivors and patients in long-term remission who take opioids, other aspects of endocrine disorders caused or exacerbated by opioids will have practical and clinical importance. "

01/01/2006 - "Short-term studies provide only equivocal evidence regarding the efficacy of opioids in reducing the intensity of neuropathic pain, whereas intermediate-term studies demonstrate significant efficacy of opioids over placebo, which is likely to be clinically important. "
06/22/2005 - "Intermediate-term studies demonstrate significant efficacy of opioids over placebo for neuropathic pain, which is likely to be clinically important. "
01/01/2015 - "Several studies demonstrated promising results in the management of both nociceptive and neuropathic pain and good tolerability profi le, particularly concerning side effects, compared to traditional opioids. "
12/01/2010 - "A number of high quality studies demonstrated that opioids are effective in relieving neuropathic pain including PHN. "
10/05/2015 - "An interesting research and therapeutic problem is the reduced beneficial efficacy of opioids in the treatment of neuropathic pain. "

02/01/1988 - "Several investigations have shown that constant rate infusions of opioids are highly effective in the provision of postoperative pain relief. "
12/01/2005 - "In addition, continuous peripheral nerve blocks showed effective and safe postoperative pain control, allowing for lower opioids consumption, improved and earlier rehabilitation, and high patient satisfaction. "
08/01/1988 - "Thus improved postoperative pain relief per se by PCA with systemic opioids had no major influence on the catabolic response to abdominal surgery."
01/01/2002 - "Clinical studies show that COX-2-selective inhibitors are effective for the treatment of preoperative and postoperative pain and reduce postsurgical requirements for opioids. "
11/01/2015 - "Opioid analgesics are widely used and effective in controlling postoperative pain, but their use poses risks that many patients don't understand and that all too often result in adverse outcomes. "

05/01/2013 - "Consistent with existing evidence, most patients with dyspnea received opioids but only the combination of opioids and BZDs was independently associated with improvement in dyspnea. "
12/01/2014 - "The opioids used for treating dyspnea do not significantly compromise respiratory function; they are safe and effective."
03/01/2010 - "One review of randomized controlled trials and another randomized controlled trial found opioids effective in relieving dyspnea without causing major adverse effects. "
06/01/2010 - "The 'dyspnea target' and 'opioid responsiveness score' are proposed as a means of defining more clearly the sensations encountered by a given patient and the likelihood of symptomatic improvement in response to opioids. "
05/01/2015 - "Opioids are an effective treatment for dyspnea. "