Chemoprevention

06/01/2013 - "With the rapidly increasing burden of preventable cancers in developing countries, efficient and feasible chemoprevention study designs and approaches, such as employed in BEST, may prove both timely and potentially beneficial in conceiving cancer chemoprevention trials in Bangladesh and beyond."
01/01/2006 - "Since most studies on these drugs were conducted on animal models or cell culture, further studies are needed to determine the efficacy of these drugs in chemoprevention of human cancers."
10/01/2011 - "Most nutritional chemoprevention agents also have the added benefit of being beneficial for the cardiovascular system, bone health and for the prevention of other cancers."
06/01/2000 - "A recent human intervention trial showed that daily supplementation with selenized yeast (Se-yeast) led to a decrease in the overall cancer morbidity and mortality by nearly 50%; past research has also demonstrated that selenized garlic (Se-garlic) is very effective in mammary cancer chemoprevention in the rat model. "
09/01/2006 - "The development of new drugs for the control of these targets that are both safe and effective will be important for the future of cancer chemoprevention."

01/01/2004 - "Chemoprophylaxis is highly effective in reducing mortality and morbidity from malaria in young children and pregnant women living in endemic areas, but is difficult to sustain and, in some studies, has impaired the development of naturally acquired immunity. "
01/01/2015 - "Seasonal malaria chemoprevention (SMC) has been shown to be highly efficacious against clinical malaria in areas where transmission is acutely seasonal. "
02/01/2013 - "Although directly observed therapy is still the gold standard of malaria chemoprophylaxis, use of cellular telephone texting technology, or SMS, for communicating ingestion may be the best alternative for reasonable accountability in the deployed setting, especially considering the highly decentralized nature of this and other deployment locations."
01/01/2012 - "Seasonal malaria chemoprevention, previously known as intermittent preventive treatment in children, is highly effective in areas with a short malaria transmission season. "
10/01/1998 - "Yet, most of travelers' diseases such as malaria cannot be prevented by vaccination and appropriate preventive measures (chemoprophylaxis and protection against insects) should be taken."

06/17/2004 - "Further studies are warranted to elucidate the efficacy of chemoprevention in women at a very high risk of breast cancer, e.g. "
07/01/2013 - "These barriers include the inability to accurately predict future breast cancer diagnosis at the individual level, the need for improved understanding of when to implement interventions, uncertainty with respect to optimal duration of treatment, and negative side effects associated with currently approved chemoprevention therapies. "
11/01/2006 - "Positive results of several recent clinical trials for preventing breast cancer in high-risk populations suggest that chemoprevention is a rational and attractive strategy."
12/01/2015 - "Undoubtedly, novel treatment strategies are needed for chemoprevention of high-risk women and for the treatment of receptor-negative breast cancer. "
02/01/2014 - "Undoubtedly novel treatment strategies are needed for chemoprevention of high risk women and for the treatment of receptor negative breast cancer. "

09/01/1994 - "These data indicate that chemoprophylaxis is highly effective in preventing primary PCP and improving survival time in infants with human immunodeficiency virus-1 infection."
01/01/2007 - "However, the QFT test was not helpful for reducing the indication of chemoprophylaxis because the infection rates were very high in our case. "
10/01/2003 - "Further study in larger populations is needed to explore whether antifungal chemoprophylaxis or other strategies may be effective in preventing fungal infection in high-risk neonates. "
01/01/2014 - "These negative effects of Peretinoin on HCV infection may be beneficial in addition to its potential for HCC chemoprevention in HCV-infected patients. "
08/01/1999 - "Intrapartum chemoprophylaxis has resulted in a significant reduction of group B Streptococcus neonatal infection. "

03/01/2006 - "At this time, nothing has been proven effective as chemoprevention against clinically significant prostate cancer."
01/01/2002 - "There are a number of moderate to high-risk cohorts and clinical models of primary and secondary prevention that can be employed in both short-term developmental (translational) trials for proof of biologic activity and in intermediate sized longer-term chemoprevention trials for proof of efficacy against prostate cancer. "
04/01/2001 - "In addition to the higher incidence of prostate cancer among African Americans compared with other populations, the mortality of prostate cancer among this high-risk population is significantly greater than 100% compared with other populations, thus further demonstrating the need for chemoprevention in this target population. "
03/01/2011 - "Improvement in the cost-effectiveness of chemoprevention for prostate cancer could be realized through the identification of patients at higher risk. "
10/20/2000 - "Television and news print media are effective in recruiting potential participants in a prostate cancer chemoprevention trial."