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Pain (Aches)

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Also Known As:
Aches; Physical Suffering; Ache; Pain, Burning; Pain, Crushing; Pain, Migratory; Pain, Radiating; Pain, Splitting; Burning Pain; Burning Pains; Crushing Pain; Crushing Pains; Migratory Pain; Migratory Pains; Pains, Burning; Pains, Crushing; Pains, Migratory; Pains, Radiating; Pains, Splitting; Physical Sufferings; Radiating Pain; Radiating Pains; Splitting Pain; Splitting Pains; Sufferings, Physical; Suffering, Physical
Networked: 219111 relevant articles (28338 outcomes, 34233 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Inflammation (Inflammations)
3. Osteoarthritis
4. Chronic Pain
5. Neuralgia (Stump Neuralgia)

Experts

1. Arendt-Nielsen, Lars: 289 articles (12/2022 - 01/2000)
2. Manchikanti, Laxmaiah: 221 articles (01/2022 - 01/2002)
3. Kaye, Alan D: 187 articles (05/2022 - 06/2002)
4. Moore, R Andrew: 160 articles (01/2022 - 06/2002)
5. Derry, Sheena: 148 articles (05/2019 - 04/2004)
6. Jensen, Mark P: 140 articles (11/2022 - 04/2001)
7. Kehlet, Henrik: 138 articles (01/2022 - 02/2001)
8. Mercadante, Sebastiano: 137 articles (05/2022 - 05/2002)
9. Porreca, Frank: 136 articles (10/2022 - 09/2001)
10. Ohtori, Seiji: 135 articles (02/2022 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pain:
1. Analgesics (Analgesic Drugs)IBA
2. Opioid Analgesics (Opioids)IBA
08/18/2015 - "However, close reading of the primary literature supports a different conclusion: opioids have been shown in randomized controlled trials (RCTs) to be highly effective in the treatment of chronic nonmalignant pain; long-term follow-up studies have shown that this effectiveness can be maintained; and effectiveness has been limited in many clinical trials by failure to take into account high variability in dose requirements, failure to adequately treat depression, and use of suboptimal outcome measures. "
10/01/1999 - "Alternative approaches to reducing visceral sensation include the use of the opioid kappa agonists, which have no central opioid effects although clinical trials have suggested that these agents are not highly effective in relieving IBS pain. "
12/01/2022 - "Delivery pain is the most unbearable pain and can be relieved with intrathecal opioids. "
03/01/2022 - "In this small sample of patients undergoing highly individualized and variable opioid taper, the opioid taper was significantly associated with improved pain responses to the cold-pressor test, with the pain threshold on average increasing by 1.14 s every 6 weeks (p = 0.0084, 95% confidence interval [CI] for 6-week change 0.3039-2.0178) and pain tolerance on average increasing by 2.87 s every 6 weeks (p = 0.0026, 95% CI for 6-week change 1.02-4.7277). "
01/01/2022 - "Although surgical revascularization is extremely effective in alleviating ischemic pain related to PAD, it is unclear whether this practice results in the discontinuation of opioids after surgery. "
3. Morphine (MS Contin)FDA LinkGeneric
4. Lidocaine (Xylocaine)FDA LinkGeneric
5. Acetaminophen (Paracetamol)FDA LinkGeneric
6. Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
7. SteroidsIBA
8. Adrenal Cortex Hormones (Corticosteroids)IBA
04/05/2023 - "However, regarding pain, the group injected with HA and PRP achieved the best results after 6 months, while patients treated with HA and corticosteroids obtained the best results at the end of the 1st week. "
02/01/1984 - "Although only a part of the management of soft tissue rheumatic conditions, a carefully given corticosteroid injection can be dramatically effective for severe pain localised to a bursa, tendon sheath or synovial space."
10/01/2015 - "The experimental groups showed a marked reduction in pain sensation and size of lesions, particularly in the final follow-up period, but there was no significant difference between the first two Groups I and II. However, healing of lesions and improvement of pain sensation was effective in Group III since a significant difference was found favoring Group III over both Groups I and II. No significant difference was found in treating erosive-ulcerative lesions of OLP by topical corticosteroids alone or combined with antifungal. "
09/01/2015 - "All the females experienced pain, and there was an optimal response to corticosteroid treatment in 100% of patients who required medical treatment (one case showed spontaneous resolution). "
08/01/2023 - "No improvement in pain between autologous PRP and corticosteroids study subjects was noted in the initial period up to 15 days whereas after 1 month, 3 months and 6 months duration, it is seen that autologous PRP injected study subjects showed significant relief in pain compared to corticosteroids. "
9. Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric
10. Local AnestheticsIBA

Therapies and Procedures

1. Therapeutics
2. Analgesia
3. Injections
4. Aftercare (After-Treatment)
5. Pain Management