TNF-Related Apoptosis-Inducing Ligand

A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.

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Networked: 770 relevant articles (15 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Griffith, Thomas S: 17 articles (10/2012 - 06/2002)
2.	Zauli, Giorgio: 15 articles (01/2015 - 08/2003)
3.	Secchiero, Paola: 14 articles (01/2015 - 08/2003)
4.	Yagita, Hideo: 14 articles (12/2012 - 02/2002)
5.	Park, Sang-Youel: 10 articles (03/2015 - 02/2002)
6.	Lee, Kang Choon: 9 articles (01/2014 - 12/2010)
7.	Smyth, Mark J: 9 articles (10/2008 - 02/2002)
8.	Okumura, Ko: 8 articles (12/2012 - 10/2002)
9.	Sanlioglu, Salih: 8 articles (01/2012 - 10/2004)
10.	Takeda, Kazuyoshi: 8 articles (12/2011 - 02/2002)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2006 - "Contrary to the known rapid clearance of systemically delivered TRAIL protein from the blood circulation, stTRAIL expressed by Ad-stTRAIL in tumor tissues persisted for more than 4 days. " 10/31/2011 - "TNF-related apoptosis inducing ligand (TRAIL), known to have tumor cell-specific killing activity, has been investigated as a novel therapeutic for cancers. " 11/15/2013 - "TNF-related apoptosis-inducing ligand (TRAIL) holds promise for treatment of cancer due to its ability to selectively kill cancer cells while sparing normal cells. " 05/01/2011 - "Improved biological half-life and anti-tumor activity of TNF-related apoptosis-inducing ligand (TRAIL) using PEG-exposed nanoparticles." 03/01/2015 - "The present study demonstrated that DFO inhibited TRAIL-mediated tumor cell death via the autophagy pathway, and the results suggest that potent anticancer agent, DFO, can be an inhibitor against antitumor therapy including TRAIL protein. "
2.	Glioma (Gliomas) 01/01/2014 - "We hypothesized that mesenchymal stem cells (MSCs) delivered via nasal application could impart therapeutic efficacy when expressing TNF-related apoptosis-inducing ligand (TRAIL) in a model of human glioma. " 02/01/2008 - "The major aim of this study was to develop novel therapeutic approaches to potentiate and reactivate apoptosis induced by TNF-Related Apoptosis Inducing Ligand (TRAIL) in malignant glioma. " 06/01/2014 - "We report that adenovirus mediated TNF-related apoptosis-inducing ligand (TRAIL) influenced the cell growth and cell cycle in the glioma cells in vitro. " 03/01/2008 - "TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in TRAIL-sensitive human malignant glioma cells. " 01/01/2007 - "Mechanisms of resistance of human glioma cells to Apo2 ligand/TNF-related apoptosis-inducing ligand."
3.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "In vitro studies into the role of OPG produced by breast tumor cells have demonstrated that OPG can block TNF-related apoptosis inducing ligand (TRAIL)-mediated apoptosis. " 06/04/2012 - "BSP showed a strong synergistic enhancement of cytotoxic activity of TNF-related apoptosis-inducing ligand (TRAIL) in human breast cancer cells. " 12/01/2010 - "Is there any correlation between TNF-related apoptosis-inducing ligand (TRAIL) genetic variants and breast cancer?" 08/30/2010 - "TRAIL protein expression in breast cancer cells correlates with nuclear grade." 11/01/2000 - "Most breast cancer cell lines are resistant to TNF-related apoptosis inducing ligand (TRAIL) induced apoptosis. "
4.	Leukemia 02/01/2005 - "This study was aimed to detect the expression of TNF related apoptosis-inducing ligand (TRAIL) and its receptors on acute myeloid leukemic (AML) cells, and explore its possible role in leukemia therapy. " 01/01/2013 - "Multi-level disruption of the extrinsic apoptotic pathway mediates resistance of leukemia cells to TNF-related apoptosis-inducing ligand (TRAIL)." 03/28/2013 - "BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia." 05/01/2003 - "TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells." 11/15/2014 - "The combination of dasatinib with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) was supposed to be effective for leukemia therapy. "
5.	Lung Neoplasms (Lung Cancer) 01/01/2006 - "To overcome this, we constructed a replication-deficient adenovirus that carries a human full-length TRAIL gene (Ad-TRAIL) and tested its efficacy against a lung cancer model system in comparison to that of the recombinant soluble TRAIL protein. " 01/26/2001 - "Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells." 05/28/2013 - "Here we describe different ways that are currently explored to induce apoptosis in lung cancer cells, specifically pathways controlled by TNF-related apoptosis-inducing ligand (TRAIL), BCL-2 family members and apoptosis inhibitory proteins (IAPs). " 08/01/2009 - "Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis in the FHIT-negative non-small lung cancer cell line Calu-1. " 07/01/2009 - "We tested the combinatorial apoptotic strategy of using bortezomib together with TNF-related apoptosis-inducing ligand (TRAIL), both in monolayers and in spheroids of A549 lung cancer cells. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Doxorubicin (Adriamycin)
3.	Death Domain Receptors
4.	Cytosine Deaminase
5.	TNF-Related Apoptosis-Inducing Ligand Receptors
6.	Caspase 3 (Caspase-3)
7.	Serum Albumin
8.	Indicators and Reagents (Reagents)
9.	Interleukin-1beta (Interleukin 1 beta)
10.	Matrix Metalloproteinase 7 (Matrilysin)

Related Therapies and Procedures

1.	Oral Administration
2.	Drug Therapy (Chemotherapy)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Therapeutics
5.	Ligation