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TNF-Related Apoptosis-Inducing Ligand

A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
Also Known As:
Apo-2 Ligand; Apo-2L Protein; CD253 Antigen; TNF Superfamily, Member 10; TRAIL Protein; Antigen, CD253; Apo 2 Ligand; Apo 2L Protein; Apoptosis-Inducing Ligand, TNF-Related; TNF Related Apoptosis Inducing Ligand; Tumor Necrosis Factor Ligand Superfamily Member 10
Networked: 1128 relevant articles (23 outcomes, 124 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Secchiero, Paola: 26 articles (11/2021 - 08/2003)
2. Zauli, Giorgio: 26 articles (11/2021 - 08/2003)
3. Griffith, Thomas S: 20 articles (09/2017 - 06/2002)
4. Yagita, Hideo: 16 articles (01/2021 - 02/2002)
5. Park, Sang-Youel: 12 articles (11/2017 - 02/2002)
6. Lee, Kang Choon: 10 articles (03/2016 - 12/2010)
7. Micheau, Olivier: 9 articles (10/2021 - 03/2003)
8. Trauzold, Anna: 9 articles (06/2021 - 04/2008)
9. Walczak, Henning: 9 articles (01/2021 - 12/2002)
10. Okumura, Ko: 9 articles (01/2020 - 10/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Glioma (Gliomas)
3. Breast Neoplasms (Breast Cancer)
4. Necrosis
5. Leukemia

Related Drugs and Biologics

1. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2. Ligands
3. Proteins (Proteins, Gene)
4. Death Domain Receptors
5. TNF-Related Apoptosis-Inducing Ligand Receptors
6. Doxorubicin (Adriamycin)
7. Cytokine TWEAK
8. Cytosine Deaminase
9. Caspase 3 (Caspase-3)
10. Bortezomib (Velcade)

Related Therapies and Procedures

1. Therapeutics
2. Oral Administration
3. Cannula
4. Drug Therapy (Chemotherapy)
5. Ligation