Tumor Necrosis Factors

A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.

Also Known As:

Networked: 152 relevant articles (5 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gisbert, Javier P: 2 articles (06/2021 - 03/2013)
2.	Kopylov, Uri: 2 articles (06/2021 - 11/2017)
3.	Kocijan, Roland: 2 articles (01/2015 - 01/2015)
4.	Muschitz, Christian: 2 articles (01/2015 - 01/2015)
5.	Rech, Jürgen: 2 articles (01/2015 - 01/2015)
6.	Abdollahi, Mohammad: 2 articles (07/2007 - 01/2007)
7.	Nikfar, Shekoufeh: 2 articles (07/2007 - 01/2007)
8.	Rahimi, Roja: 2 articles (07/2007 - 01/2007)
9.	Fan, Dazhi: 1 article (05/2022)
10.	Ma, Yubo: 1 article (05/2022)

Related Diseases

1.	Crohn Disease (Crohn's Disease) 01/01/2007 - "To determine whether anti-tumor necrosis factors induce clinical response and remission in patients with Crohn's disease, PUBMED, OVID, and SCOPUS databases were searched for studies investigated the efficacy of anti-tumor necrosis factors on CD. " 01/01/2007 - "It seems that anti-tumor necrosis factors are not effective for induction of response and remission in patients with Crohn's disease." 01/01/2007 - "Do anti-tumor necrosis factors induce response and remission in patients with acute refractory Crohn's disease? " 11/01/2017 - "Consecutive patients with Crohn's disease treated with anti-tumor necrosis factors after surgery were identified in the databases of the participating centers. " 03/01/2013 - "The sample comprised 100 patients (mean age, 42 years; 68% Crohn's disease; 49% on thiopurines; and 14% on anti-tumor necrosis factors during follow-up). "
2.	Ulcerative Colitis 02/01/2019 - "We reported before two cases of collagenous colitis developed in patients with Crohn's disease and ulcerative colitis while they were in complete mucosal remission after being treated with tumor necrosis factors-α inhibitors. " 07/01/2018 - "Expert opinion: A phase II study in moderate-to-severe ulcerative colitis (UC) patients, both naïve and previously exposed to anti-tumor necrosis factors, showed that PF-00547659 was superior to placebo for induction of remission, response, and mucosal healing at week 12. " 07/01/2007 - "The keywords used to search were "ulcerative colitis" with "infliximab", "anti tumor necrosis factor", or "anti tumor necrosis factors". " 06/01/2014 - "Anti-tumor necrosis factors (anti-TNF) including infliximab, adalimumab and certolizumab pegol are used to treat Crohn's disease (CD) and ulcerative colitis (UC). " 01/01/2016 - "In the era of biologics, laboratory tests have become essential to evaluate the inflammatory burden of the disease (C-reactive protein, fecal calprotectin) since symptoms-based scores are subjective, to predict the response to pharmacological options and the risk of relapse, to discriminate CD from ulcerative colitis, to select candidates to anti-tumor necrosis factors [screening tests looking for hepatitis B virus and hepatitis C virus status and latent tuberculosis], to assess the risk of adverse events (testing for thiopurine metabolites and thiopurine-methyltransferase activity), and to personalize and optimize therapy (therapeutic drug monitoring). "
3.	Chronic Hepatitis C 02/16/2016 - "Safety and efficacy of anti-tumor necrosis factors α in patients with psoriasis and chronic hepatitis C." 03/01/2002 - "We hypothesized that polymorphisms within the major histocompatibility complex class III region that encode for tumor necrosis factors (TNF)-alpha and TNF-beta might be predictive of response to antiviral therapy in patients with chronic hepatitis C. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 11/01/2020 - "Tumor necrosis factors-α inhibition-induced paradoxical psoriasis: A case series and literature review." 02/16/2016 - "Safety and efficacy of anti-tumor necrosis factors α in patients with psoriasis and chronic hepatitis C."
5.	Axial Spondyloarthritis 01/01/2015 - "Since there is no evidence regarding the efficacy of conventional synthetic disease modifying anti-rheumatic drugs in the improvement of axial spondyloarthritis (SpA), anti-tumor necrosis factors (anti-TNFs) are recommended if nonsteroidal anti-inflammatory drugs fail, or in case of high disease activity. " 12/01/2019 - "anti-tumor necrosis factors) are effective treatments for multiple chronic inflammatory diseases including rheumatoid arthritis, axial spondyloarthritis, and psoriatic arthritis. "

Related Drugs and Biologics

1.	Antirheumatic Agents (DMARD)
2.	2-mercaptopurine
3.	thiopurine methyltransferase (thiopurine S-methyltransferase)
4.	Biomarkers (Surrogate Marker)
5.	vedolizumab
6.	Interferons
7.	NF-kappa B (NF-kB)
8.	Infliximab (Remicade)
9.	Ligands
10.	Adalimumab (Humira)

Related Therapies and Procedures

1.	Therapeutics
2.	Remission Induction
3.	Fecal Microbiota Transplantation
4.	Drug Therapy (Chemotherapy)
5.	Hematopoietic Stem Cell Transplantation