Chaperonin 60

A group I chaperonin protein that forms the barrel-like structure of the chaperonin complex. It is an oligomeric protein with a distinctive structure of fourteen subunits, arranged in two rings of seven subunits each. The protein was originally studied in BACTERIA where it is commonly referred to as GroEL protein.

Also Known As:

Networked: 391 relevant articles (10 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Prakken, Berent J: 9 articles (01/2013 - 07/2002)
2.	Wick, Georg: 9 articles (10/2011 - 01/2003)
3.	Wick, G: 9 articles (12/2007 - 03/2000)
4.	Yamazaki, K: 7 articles (04/2014 - 05/2000)
5.	Albani, Salvatore: 7 articles (10/2012 - 07/2002)
6.	Henderson, Brian: 6 articles (12/2014 - 04/2005)
7.	Oguma, Keiji: 6 articles (11/2009 - 01/2004)
8.	de Jager, Wilco: 5 articles (01/2013 - 07/2005)
9.	Xu, Qingbo: 5 articles (11/2009 - 06/2003)
10.	Yokota, Kenji: 5 articles (08/2009 - 01/2004)

Related Diseases

1.	Infection 01/01/2008 - "Immunization of mice with recombinant groEL protein with or without adjuvant conferred 70-90% protection against lethal infections either by S. " 09/01/1997 - "Heat shock protein 60 (hsp60)-specific CD8 T cells lysed Mycobacterium bovis BCG-infected macrophages in vitro and adoptively transferred protection against mycobacterial infection. " 07/13/2012 - "ratti heat shock protein 60 (srHSP60) conferred protection to challenge infection. " 01/20/2012 - "Vaccination with Strongyloides ratti heat shock protein 60 increases susceptibility to challenge infection by induction of Th1 response." 08/01/2010 - "To test whether this epitope can protect against WNV infection, we synthesized a linear chimeric peptide composed of Ep15 and the heat-shock protein 60 peptide, p458. "
2.	Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis) 07/01/2011 - "Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis." 11/01/1996 - "Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis." 01/01/2009 - "Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new?" 07/01/2003 - "To test the hypothesis that T cell reactivity to self heat-shock protein 60 (Hsp60) in patients with remitting juvenile idiopathic arthritis (JIA) is part of an antiinflammatory, regulatory mechanism. " 07/01/2003 - "The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10."
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 08/01/1998 - "We believe our results represent strong evidence that B cells are required as APCs to generate pathogenic autoimmune T cell responses and provide a direct correlation between the protection from autoimmune diabetes previously reported in B cell-deficient NOD mice and the lack of anti-GAD65 and anti-heat shock protein 60 T cell responses in these mice." 09/01/1995 - "Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277." 10/01/2005 - "DiaPep277, a 24-amino acid peptide based on residues 437 to 460 of heat shock protein 60, is undergoing phase II clinical trials by DeveloGen for the potential treatment and prevention of established and newly diagnosed type 1 diabetes symptoms of the prediabetic state and of latent autoimmune diabetes of the adult." 07/01/2004 - "One of the immunodominant epitopes in autoimmune diabetes is p277, a specific peptide of human heat shock protein 60 corresponding to positions 437-460. " 11/01/2000 - "In the nonobese diabetic mouse, an autoimmune model of IDDM, one of the reactive beta cell autoantigens is the heat shock protein 60 (HSP60). "
4.	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 03/01/2000 - "Some study results indicate that mucosal tolerance induced by appropriate recombinant peptide fragments of human AChR is effective in suppressing experimental autoimmune myasthenia gravis and might be considered as a therapeutic modality for patients with MG. A peptide of the heat-shock protein 60 molecule, designated peptide p277, was shown to be a target of T cells in autoimmune diabetes in NOD mice, and intraperitoneal injections of glutamic acid decarboxylase (GAD) peptide 524-543 delayed the onset of diabetes and significantly reduced its incidence. "
5.	Shock 12/01/2009 - "We find that these cells, although lacking a HSR to heat shock treatment, show an enhancement of DnaK and GroEL protein levels after 30 or 90 min sinusoidal ELF-MF exposure (50 Hz, 1 mT). " 08/01/2003 - "We used quantitative two-dimensional gel electrophoresis for determining whether either the constitutive chaperonic heat shock cognate protein 70 (hsc70) or heat shock protein 60 (hsp60) contribute to B-cell differentiation and leukemogenesis. " 08/15/1996 - "Synthesis of a ubiquitously present new HSP60 family protein is enhanced by heat shock only in the Malpighian tubules of Drosophila." 08/20/1991 - "Chaperonin 60 was 9.3% of the total soluble cell protein during photolithoautotrophic growth which increased to 28.5% following heat-shock treatment. " 01/01/1991 - "micdadei specific anti-groEL antibody did not reveal a significant increase in the amount of the GroEL protein during heat shock in L. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Epitopes
3.	Glutamate Decarboxylase (Decarboxylase, Glutamate)
4.	Peptide Fragments
5.	Interleukin-10 (Interleukin 10)
6.	Interferon-gamma (Interferon, gamma)
7.	Bacterial Antigens
8.	Antibodies
9.	Antigens
10.	Heat-Shock Proteins (Heat-Shock Protein)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Transplants (Transplant)
3.	Transplantation (Transplant Recipients)
4.	Injections
5.	Immunotherapy