Heat-Shock Proteins (Heat-Shock Protein)

Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.

Also Known As:

Networked: 6371 relevant articles (160 outcomes, 563 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Calderwood, Stuart K: 32 articles (03/2015 - 04/2002)
2.	Neckers, Len: 30 articles (08/2015 - 01/2002)
3.	Workman, Paul: 26 articles (05/2014 - 01/2002)
4.	Chiosis, Gabriela: 22 articles (05/2014 - 10/2002)
5.	Multhoff, Gabriele: 19 articles (12/2015 - 05/2004)
6.	Wang, Xiang-Yang: 15 articles (08/2013 - 01/2002)
7.	Subjeck, John R: 15 articles (08/2013 - 01/2002)
8.	Gong, Jianlin: 15 articles (07/2013 - 07/2004)
9.	Prohászka, Zoltán: 15 articles (01/2012 - 02/2002)
10.	Blagg, Brian S J: 14 articles (07/2015 - 09/2006)

Related Diseases

1.	Neoplasms (Cancer) 12/15/2007 - "The small heat shock protein Hsp27 is expressed at high levels in many tumors and provides protection against anticancer drugs. " 07/01/2004 - "Moreover, cells expressing heat shock proteins during cell death are significantly more protective against subsequent tumor challenge. " 08/01/2001 - "In recent years, heat shock proteins have been shown to be effective in enhancing the immunogenicity of tumors. " 03/01/2011 - "Structure based drug design (SBDD) was used to discover heat shock protein 90 (HSP90) inhibitors useful in the treatment of cancer. " 05/01/2015 - "Elevated levels of heat shock proteins (HSPs) contribute to tumor cell survival and mediate protection against radiation-induced cell death. "
2.	Shock 07/01/1989 - "The clone has a length of 1.1 kb and codes for the complete heat-shock protein which was reported to be associated with the grana region of the thylakoid membranes and ascribes protection against photoinhibition during heat-shock. " 05/01/2004 - "This screening yielded three promoters of genes belonging to the heat shock regulon (dnaK, lon, clpPX), suggesting a role for heat shock proteins in protection against, and/or repair of, damage caused by high pressure. " 02/01/2005 - "Indeed, there is experimental evidence that overexpression of specific heat shock proteins or heat shock factors produce protective effects similar to those observed after stress preconditioning. " 12/01/1995 - "Recent studies have shown that improved myocardial salvage after heat-shock pretreatment correlates with the amount of induced cardiac heat-shock protein (HSP)72. " 06/01/2010 - "Expression of heat shock factors and subsequent heat shock protein plays a role in protection against proteotoxicity in invertebrate and vertebrate models. "
3.	Fever (Fevers) 06/01/2001 - "We examined the effect of aging on the capacity of the brain to produce heat shock protein (Hsp70) in response to heat stress, using high-powered microwaves (HPM, 2.06 GHz, 2.2 W/cm(2)) to induce hyperthermia for periods so brief that thermoregulatory factors were functionally eliminated as confounding variables. " 02/01/1992 - "Although ventricular samples from rats subjected to either hyperthermia (n = 7) or ischemic pretreatment (n = 6) all showed induction of HSP72 (heat shock protein), Western blot analysis revealed significantly greater amounts of HSP72 in samples obtained from rats subjected to hyperthermia compared with those from rats subjected to ischemic pretreatment. " 05/01/2011 - "Chronic repeated exposure to hyperthermia in humans results in heat acclimation (HA), an adaptive process that is attained in humans by repeated exposure to hyperthermia and is characterized by improved heat elimination and increased exercise capacity, and acquired thermal tolerance (ATT), a cellular response characterized by increased baseline heat shock protein (HSP) expression and blunting of the acute increase in HSP expression stimulated by re-exposure to thermal stress. " 01/01/2011 - "Hyperthermia has been shown to induce expression of heat shock proteins (HSPs) to provide protection against a variety of stresses. " 08/01/2006 - "Heat-induced expression of cytoprotective and antiapoptotic heat shock proteins (HSP) is a known complication of hyperthermia, resulting in thermotolerance and chemoresistance and hindering the efficacy of the combination therapy. "
4.	Infection 01/01/2003 - "These findings suggest an important role for heat shock proteins in host protection against pathogenic infection. " 11/01/2010 - "Influence of heat shock proteins induction in different yeast cell wall mutants on the protection against Vibrio campbellii infection in gnotobiotically grown Artemia franciscana (Kellogg)." 10/01/2001 - "The heat-inducible 70-kDa heat shock protein (Hsp70) has been associated with protection of leukocytes against the cytotoxicity of inflammatory mediators and with improved survival of severe infections. " 01/01/1996 - "We have previously reported that the expression of an endogenous 65-kD heat shock protein (HSP65) in macrophages is closely correlated with the protection against infection by Toxoplasma gondii in mice, and gamma delta T cells play a critical role in the expression of this protein. " 02/01/2012 - "This study was conducted to determine the effects of heat shock protein (Hsp)70 expression on resistance to Salmonella enteritidis infection in broiler chickens subjected to heat exposure. "
5.	Ischemia 07/11/1994 - "We will also discuss that stress proteins may be involved in the central nervous system after ischemia in two important aspects: early protection against stress and restoration of damaged lesions in the brain at later stages after ischemia." 03/01/1998 - "We hypothesized that free musculocutaneous flap survival could be improved by enhancing the flap's tolerance to relative ischemia by the prior induction of heat shock proteins. " 06/01/2001 - "Myocardial content of the 70-kd heat shock protein has been found to correlate with improved cardiac recovery after ischemia, but the mechanisms and conditions that regulate its level, particularly under clinical conditions, are unclear. " 10/07/1997 - "Simultaneous overexpression of two stress proteins in rat cardiomyocytes and myogenic cells confers protection against ischemia-induced injury." 01/01/2014 - "The aim of this study was to examine the release of small constitutive heat shock proteins (HSPs) from human and mouse myocardium after global ischemia and examine the role of extracellular small HSP in myocardial injury. "

Related Drugs and Biologics

1.	Antigens
2.	Vaccines
3.	Antibodies
4.	Peptides
5.	DNA (Deoxyribonucleic Acid)
6.	17-(allylamino)-17-demethoxygeldanamycin (17AAG)
7.	Molecular Chaperones (Chaperone, Molecular)
8.	Interleukin-2 (IL2)
9.	Heat-Shock Proteins (Heat-Shock Protein)
10.	pristane (pristan)

Related Therapies and Procedures

1.	Immunotherapy
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Stem Cell Transplantation
5.	Splenectomy