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Glutamate Decarboxylase (Decarboxylase, Glutamate)

A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
Also Known As:
Decarboxylase, Glutamate; Glutamic Acid Decarboxylase; Acid Decarboxylase, Glutamic; Carboxy-Lyase, Glutamate; Decarboxylase, Glutamic Acid; Glutamate Carboxy Lyase; Glutamate Carboxy-Lyase; L-Glutamate-1-carboxy-lyase
Networked: 2027 relevant articles (25 outcomes, 205 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Huang, Gan: 24 articles (01/2022 - 01/2003)
2. Ludvigsson, Johnny: 23 articles (01/2022 - 03/2006)
3. Hampe, Christiane S: 22 articles (01/2022 - 08/2002)
4. Zhou, Zhiguang: 21 articles (01/2022 - 11/2003)
5. Knip, Mikael: 20 articles (01/2022 - 01/2002)
6. Vincent, Angela: 20 articles (01/2017 - 03/2005)
7. Li, Xia: 18 articles (01/2022 - 01/2003)
8. Lewis, David A: 16 articles (01/2021 - 12/2002)
9. Ilonen, Jorma: 14 articles (01/2022 - 06/2003)
10. Bien, Christian G: 13 articles (03/2022 - 04/2010)

Related Diseases

1. Type 1 Diabetes Mellitus (Autoimmune Diabetes)
2. Cerebellar Ataxia (Dysmetria)
3. Limbic Encephalitis (Paraneoplastic Limbic Encephalitis)
4. Diabetes Mellitus
5. Insulinoma

Related Drugs and Biologics

1. Autoantibodies
2. aluminum sulfate (alum)
3. Insulin (Novolin)
4. Antibodies
5. C-Peptide
6. Antigens
7. Zinc Transporter 8
8. Aluminum
9. Intravenous Immunoglobulins (IVIG)
10. gamma-Aminobutyric Acid (GABA)

Related Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Glycemic Control
4. Intraperitoneal Injections
5. Bariatric Surgery