HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Adenosine Triphosphatases (ATPase)

Subscribe to New Research on Adenosine Triphosphatases

A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.

Also Known As:

ATPase; ATPases; Adenosine Triphosphatase; Adenosinetriphosphatase; ATPase, DNA-Dependent; DNA-Dependent ATPase; DNA-Dependent Adenosinetriphosphatases; ATPase, DNA Dependent; Adenosinetriphosphatases, DNA-Dependent; DNA Dependent ATPase; DNA Dependent Adenosinetriphosphatases; Triphosphatase, Adenosine; ATP phosphohydrolase

Networked: 6439 relevant articles (149 outcomes, 688 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Acid Anhydride Hydrolases
      - Adenosine Triphosphatases: 6439
        Sodium-Potassium-Exchanging ATPase: 537
        Proton-Translocating ATPases: 275
        Calcium-Transporting ATPases: 227
        CDC48 protein: 175
        RecQ Helicases: 169
        Ca(2+) Mg(2+)-ATPase: 150
        DNA Helicases: 86
        copper-transporting ATPases: 81
        ectoATPase: 76
        spermatogenesis associated factor: 54
        oligomycin sensitivity-conferring protein: 51
        Mi-2 Nucleosome Remodeling and Deacetylase Complex: 50
        Chaperonins: 38
        N-Ethylmaleimide-Sensitive Proteins: 33
        condensin complexes: 27
        sodium-translocating ATPase: 17
        katanin: 13
        Wilson disease protein: 9
        human PMS2 protein: 8
        Molecular Motor Proteins: 7
        anion-sensitive ATPases: 5
        potassium transporting ATPase: 3
        manganese ATPase: 2
        p97 ATPase: 2
        RNA-dependent ATPase: 2
        TER ATPase: 2
        calcium potassium ATPase: 1
        MutS DNA Mismatch-Binding Protein: 1
        PAN enzyme: 1
        rho-ATPase: 1
        single stranded DNA dependent ATPase: 1
        Actinobacillus actinomycetemcomitans TadA protein
        Arabidopsis At4g30490 protein
        Arabidopsis BRM protein
        Arabidopsis CAP-C protein
        Arabidopsis CIP111 protein
        Arabidopsis DRH1 protein
        Arabidopsis HMA1 protein
        Arabidopsis HMA2 protein
        Arabidopsis HMA3 protein
        Arabidopsis HMA4 protein
        Arabidopsis HMA7 protein
        Arabidopsis KTN1 protein
        Arabidopsis MinD1 protein
        Arabidopsis MLH1 protein
        Arabidopsis NAP1 protein
        Arabidopsis PDR2 protein
        Arabidopsis PEROXIN6 protein
        Arabidopsis RPT5a protein
        Arabidopsis RPT5b protein
        Arabidopsis SPLAYED protein
        Arabidopsis TGD3 protein
        Archaea CopB protein
        Arsenite Transporting ATPases
        ATPase-dATPase
        Bacillus subtilis mecB protein
        bacteria ClpE protein
        bacteria MgtA protein
        bacteria NtpJ protein
        Bacteria phosphate import ATP-binding protein
        Bacteria SecA protein
        bacteriophage phi29 protein p16
        bacteriophage SPP1 terminase
        Brevibacillus choshinensis DnaK protein
        C elegans CATP-5 protein
        C elegans F32D1.1 protein
        C elegans Lex-1 protein
        C elegans MEI-1 protein
        C elegans MEI-2 protein
        C elegans OOC-5 protein
        C elegans SSL-1 protein
        cadmium translocating ATPase
        Citrobacter freundii DhaF protein
        Citrobacter freundii DhaG protein
        Dictyostelium discoideum DVA41 protein
        Drosophila CAP-D3 protein
        Drosophila katanin p60-like 1 protein
        Drosophila katanin-60 protein
        Drosophila Mi-2 protein
        Drosophila SMC3 protein
        Drosophila spastin protein
        Drosophila spindle E protein
        Drosophila Vha100-1 protein
        Drosophila vha14 protein
        Drosophila Vps4 protein
        E coli BfpD protein
        E coli ClpX protein
        E coli Hda protein
        E coli MetN protein
        E coli MgtA protein
        E coli MinD protein
        E coli MutL protein
        E coli Par1 protein
        E coli Par2 protein
        E coli potassium translocating Kdp-ATPase
        E coli RbbA protein
        E coli SufC protein
        E coli TrwD protein
        E coli UvrA protein
        E coli YieN protein

Experts

1.	Sznajder, Jacob I: 26 articles (12/2015 - 01/2002)
2.	Wyse, Angela T S: 26 articles (04/2014 - 04/2002)
3.	Lingrel, Jerry B: 17 articles (12/2015 - 02/2005)
4.	Xie, Zijian: 17 articles (10/2015 - 01/2003)
5.	Wajner, Moacir: 16 articles (02/2013 - 04/2002)
6.	Dada, Laura A: 15 articles (12/2015 - 04/2003)
7.	Royes, Luiz Fernando Freire: 15 articles (12/2014 - 06/2003)
8.	Bagrov, Alexei Y: 14 articles (10/2015 - 02/2002)
9.	Fedorova, Olga V: 14 articles (10/2015 - 02/2002)
10.	Shapiro, Joseph I: 14 articles (10/2015 - 01/2003)

Related Diseases

1.	Ischemia 10/01/1990 - "A decrease in sarcolemmal Na+,K(+)-ATPase activity was first detected after 30 min of occlusion and a significant reduction in enzyme activity was present at 45 min of ischemia. " 08/01/2013 - "oxyphyllae ameliorates the urine concentration and renal functions in ischemia/reperfusion-induced ARF, through the restoring of AQP-2, 3 and Na,K-ATPase." 11/01/1991 - "These data suggested that K-arrest might preserve the activity of Na+/K+ ATPase during ischemia and early reperfusion, and that it attenuated the increase in Nai during ischemia and reperfusion, which resulted in less Ca++ overload during reperfusion via the Na+/Ca++ exchange mechanism and led to improved recovery." 02/01/2013 - "Previous studies have shown that ischemia-reperfusion (I/R) injury is associated with cardiac dysfunction and changes in sarcolemmal Na(+)-K(+)-ATPase subunits and activity. " 01/01/2011 - "Biotinylation studies suggested that I-R itself acted as an inducer of Na(+)-K(+)-ATPase internalization and that surface expression of the mutant was higher than the native Na(+)-K(+)-ATPase before and after ischemia. "
2.	Neoplasms (Cancer) 03/01/2001 - "The improved energy metabolism could decrease the intracellular concentration of Na+ by increasing the activity of Na+-K+-ATPase and decreasing the activity of Na+/H+. Although both 23Na and 31P spectra were consistent with improved cellular metabolism in treated tumors, the 23Na methods may be better suited for monitoring response to therapy because of higher signal:noise ratio and ease of imaging the single 23Na resonance." 06/01/1986 - "The adenosine triphosphatase reaction therefore appears to be helpful in distinguishing between benign and malignant neoplasms derived from thyroid epithelium in humans and may be a useful adjunct to routine morphology." 01/01/2009 - "Knowledge of its involvement in several diseases, including cancer, has helped to establish the importance of V-ATPase for the preservation of life." 02/06/2015 - "Previous studies have implicated V-ATPases in cancer cell invasion. " 01/01/2014 - "More importantly, a new series of pharmacologically optimized Na(+)/K(+) ATPase inhibitors has recently shown strong anti-cancer activities in multiple preclinical assays and have reached early clinical trials. "
3.	Heart Failure 06/20/2009 - "Improvement in cardiac function after sarcoplasmic reticulum Ca2+-ATPase gene transfer in a beagle heart failure model." 05/15/1999 - "Na+, K+-ATPase activity may be helpful in predicting electrophysiologic instability in patients with heart failure." 01/01/2014 - "This study aims to explore the expression and significance of ATPase in myocardium of congestive heart failure induced by pressure overload in rats. " 08/01/2009 - "The transduction of myocardial cells with viral constructs encoding a specific cardiomyocyte Ca(2+) pump in the sarcoplasmic reticulum (SR), SRCa(2+)-ATPase has been shown to correct deficient Ca(2+) handling in cardiomyocytes and improvements in contractility in preclinical studies, thus leading to the first clinical trial of gene therapy for heart failure. " 08/01/2005 - "This study was designed to determine whether chronic heart failure (CHF) results in changes in Na(+)-K(+)-ATPase properties in heart and skeletal muscles of different fiber-type composition. "
4.	Hypertension (High Blood Pressure) 07/01/1991 - "In the 40 patients with hypertension, a more marked decrease of Na+, K(+)-ATPase was observed. " 08/15/1988 - "Thus circulating Na+/K+-ATPase inhibitors may not be effective in eliciting chronic forms of hypertension unless the target cell "homeostatic response" is impaired. " 07/01/2004 - "These studies support the hypothesis that development of hypertension in SHR may involve an altered subcellular distribution of proximal tubule Na+,K+-ATPase subunits." 09/15/1998 - "These data support the alpha1 Na,K-ATPase gene as a susceptibility gene for salt-sensitive hypertension in the Dahl S rat model, and provide the basis for the study of the alpha1 Na,K-ATPase locus in human hypertension." 09/01/1998 - "This article reviews related studies from the authors' laboratory, which focus on the regulation of vascular Na+,K+-ATPase in hypertension. "
5.	Edema 09/01/1999 - "The purpose of this study was to determine whether the DA-mediated stimulation of edema clearance occurs via an adrenergic or dopaminergic regulation of alveolar epithelial Na, K-ATPase. " 10/01/1998 - "Previous studies have suggested that alveolar Na,K-ATPases play an important role in active Na+ transport and lung edema clearance. " 09/01/1994 - "The present study indicates that Na+ channels and Na(+)-K(+)-adenosinetriphosphatase, components of the active Na+ absorption transport system, are very important in opposing edema fluid accumulation in rat lungs subjected to I/R injury and operate as an edema safety factor. " 01/01/2016 - "Thus, we speculate that FXYD1 overexpression in ARDS patient lungs may limit Na(+)/K(+)-ATPase activity, and contribute to edema persistence. " 08/01/2015 - "EA of 3 mA intensity could strengthen aerobic metabolism by elevating the activities of SDH and LDH, meanwhile maintaining the ionic equilibrium in the exterior and interior brain cell and relieving the cellular edema by reinforcing the activities of Na(+)-K(+)-ATPase."

Related Drugs and Biologics

1.	Adenosine Triphosphatases (ATPase)
2.	Adenosine Triphosphate (ATP)
3.	Omeprazole (Esomeprazole)
4.	Ouabain (G Strophanthin)
5.	Enzymes
6.	Messenger RNA (mRNA)
7.	Glucose (Dextrose)
8.	Sodium
9.	Isoproterenol (Isoprenaline)
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Lenses
2.	Traditional Medicine (Folk Remedies)
3.	Lower Body Negative Pressure
4.	Resuscitation
5.	Therapeutics