Interferon-gamma (Interferon, gamma)

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.

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Networked: 12287 relevant articles (420 outcomes, 1013 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pai, Madhukar: 24 articles (10/2014 - 12/2004)
2.	Harada, Nobuyuki: 18 articles (11/2015 - 07/2004)
3.	Mori, Toru: 17 articles (01/2014 - 07/2004)
4.	Iwakura, Yoichiro: 16 articles (04/2014 - 01/2002)
5.	Higuchi, Kazue: 14 articles (11/2015 - 11/2004)
6.	Lalvani, Ajit: 13 articles (02/2014 - 05/2004)
7.	Ottenhoff, Tom H M: 13 articles (08/2012 - 09/2002)
8.	Dheda, Keertan: 12 articles (07/2015 - 07/2004)
9.	Hsueh, Po-Ren: 12 articles (01/2015 - 11/2006)
10.	Fuchs, Dietmar: 12 articles (06/2013 - 02/2004)

Related Diseases

1.	Infection 10/30/2006 - "We show that in contrast to their wild-type (WT) counterparts, CCR5-/- CD4+CD25+ nTreg cells resulted in an increased magnitude of parasite-specific, interferon gamma-producing CD4+ T cells within infection sites, dramatically reduced parasite numbers, and potent resistance to infection, a finding consistent with the clinical outcome of infected CCR5-/- mice. " 05/12/1994 - "Studies conducted in vitro and in animals suggest that cytokine signals to monocytes or macrophages by interferon gamma are important in the containment and clearance of disseminated nontuberculous mycobacterial infections. " 10/01/1999 - "Earlier investigations have not shown an important role for gamma interferon (IFN-gamma) in the early clearance of chlamydial infection from the murine female genital tract. " 09/01/1998 - "Route of infection that induces a high intensity of gamma interferon-secreting T cells in the genital tract produces optimal protection against Chlamydia trachomatis infection in mice." 04/01/1996 - "This could prove an especially important phenomenon since it is the production of interferon gamma by CD8 T cells which is seen as necessary for protection against virus infection. "
2.	Neoplasms (Cancer) 04/09/2009 - "Experimental tumor vaccination and adoptive T-cell therapies show that interferon-gamma (IFN-gamma)-producing CD4(+) T helper cells (Th1) can be highly effective in tumor prevention and therapy. " 11/28/2001 - "Interferon gamma (IFNgamma) is a potent inhibitor of cell growth effective against a wide range of tumor-derived cell lines. " 05/01/1993 - "These results suggest that NK cells infiltrate the tumor-developing lesion at an early stage and may participate in the early protection against tumors through production of a high amount of interferon-gamma and enhanced cytotoxicity at tumor-bearing sites." 12/01/1993 - "Comparing all-trans- with 9-cis-RA, the latter was more effective in inhibiting tumor cell growth and in inducing synergism with interferon-gamma. " 03/01/1990 - "Excisional biopsy specimens 12 weeks after therapy showed no evidence of tumor remaining in 7 of 14 patients (50%) treated with the higher dose of interferon gamma, whereas only 1 of 15 patients (7%) treated with low-dose interferon gamma was cured according to histologic criteria (p = 0.025). "
3.	Necrosis 12/01/1997 - "The study analyses the effects of tumour necrosis factor-alpha and interferon-gamma on proliferation, "activation" and protein synthesis of hepatic stellate cells. " 01/01/1991 - "The method was found to be suitable for study of the expression of HLA alleles on ex vivo tumour cells and allowed the detection of changes imposed by in vitro treatment with interferon gamma and tumour necrosis factor alpha." 11/01/1990 - "In this study we have demonstrated good titres of tumour necrosis factor (TNF) and interferon-gamma (IFN-gamma) in the supernatants, which accounted for their observed cytostatic activity on the tumour targets. " 03/01/1990 - "Trials of tumour necrosis factor-alpha as an anticancer agent, either singly or in combination with interferon gamma or cytotoxic drugs, are in progress. " 09/01/1988 - "This study showed that both the production and surface membrane expression of SC were additively up-regulated by tumour necrosis factor-alpha (TNF) and gamma interferon (IFN-gamma) in a human colonic cell line (HT-29m2). "
4.	Tuberculosis (Tuberculoses) 05/01/2009 - "Always having in mind the importance of clinical and epidemiological histories, these new assays based on interferon-gamma release present promising results and should be considered in tuberculosis investigation procedures for all patients, however with a special concern in the risk groups (i.e., children and immunosuppressed patients)." 10/01/2001 - "Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation." 01/01/2014 - "The diagnostic accuracy of tuberculosis (TB) remains a clinical challenge, and a number of studies have used the interferon gamma-induced protein 10 (IP-10) in the diagnosis of TB. " 11/15/2011 - "This study describes the comparison of the cell-based interferon-gamma (IFNγ) test with serological rapid antibody tests (STAT-PAK and DPP VetTB) for the ante mortem testing of tuberculosis in domestic cats. " 11/01/2010 - "This study aimed to compare the diagnostic performance of the T-cell-based interferon-gamma releasing assay (IGRA) T-SPOT.TB with the TST for the diagnosis of LTBI in an intermediate tuberculosis (TB)-burden country with high BCG coverage. "
5.	Malaria 04/01/2008 - "Previous studies have shown that gamma interferon (IFN-gamma) production in the placenta is associated with protection against placental malaria. " 12/01/2008 - "Interferon-gamma (IFN-gamma) has been implicated in both protection against and the pathogenesis of malaria in humans. " 03/01/2001 - "Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice." 04/01/2003 - "However, interferon gamma activity, associated with serious acute pathogenesis in other studies on malaria, was absent. " 12/01/2009 - "Interferon-gamma (IFN-gamma) has been suggested to play an important role in the pathogenesis of malaria. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Interleukin-2 (IL2)
3.	Antigens
4.	Cytokines
5.	Interleukin-12 (IL 12)
6.	Interleukin-10 (Interleukin 10)
7.	Interleukin-4 (Interleukin 4)
8.	Interleukins
9.	Tuberculin (PPD)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Immunotherapy
3.	Injections
4.	Transplants (Transplant)
5.	Ligation