Type 1 Diabetes Mellitus (Autoimmune Diabetes)

A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Also Known As:
Autoimmune Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Insulin-Dependent, 1; Diabetes Mellitus, Type I; Insulin-Dependent Diabetes Mellitus 1; Juvenile-Onset Diabetes; Type 1 Diabetes; Brittle Diabetes Mellitus; Diabetes Mellitus, Insulin Dependent; Diabetes Mellitus, Juvenile Onset; Diabetes Mellitus, Ketosis Prone; Diabetes Mellitus, Sudden Onset; Diabetes, Juvenile-Onset; Diabetes, Type 1; Insulin Dependent Diabetes Mellitus 1; Insulin-Dependent Diabetes Mellitus; Juvenile Onset Diabetes; Juvenile-Onset Diabetes Mellitus; Ketosis-Prone Diabetes Mellitus; Sudden-Onset Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes, Autoimmune; IDDM
Networked: 36799 relevant articles (2092 outcomes, 6685 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Type 1 Diabetes Mellitus (Autoimmune Diabetes)
2. Hypoglycemia (Reactive Hypoglycemia)
3. Type 2 Diabetes Mellitus (MODY)
4. Hyperglycemia
5. Insulin Resistance


1. Knip, Mikael: 220 articles (05/2022 - 01/2002)
2. Ilonen, Jorma: 168 articles (01/2022 - 01/2002)
3. Maahs, David M: 136 articles (06/2022 - 02/2005)
4. Atkinson, Mark A: 130 articles (01/2022 - 10/2002)
5. Rewers, Marian: 129 articles (01/2022 - 01/2002)
6. Mathieu, Chantal: 126 articles (11/2022 - 08/2002)
7. Veijola, Riitta: 125 articles (10/2022 - 05/2002)
8. Ludvigsson, Johnny: 119 articles (06/2022 - 01/2002)
9. Bonifacio, Ezio: 112 articles (01/2022 - 01/2002)
10. Yu, Liping: 103 articles (01/2022 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Type 1 Diabetes Mellitus:
1. Insulin (Novolin)FDA Link
01/01/2021 - "In this study, use of the tubeless insulin pump over 12 months was associated with significant improvement in A1C in adults with type 1 diabetes, most notably in those with an A1C ≥9.0% and those previously treated with MDI."
10/05/2019 - "Despite the improved management of type 1 diabetes with exogenous insulin, most patients do not meet clinical glycaemic goals, and diabetes remains an important medical problem that affects children and adults. "
01/01/2019 - "Unfortunately, this process is poorly understood, and the current best treatment for type 1 diabetes is the administration of exogenous insulin. "
09/01/2014 - "The life expectancy of Type 1 diabetes mellitus (T1DM) dramatically improved after the discovery of insulin in 1922, but was still 25 years shorter than that of non-diabetic population. "
01/01/2001 - "The main findings were as follows: (i) in type 1 diabetes, the combined analysis of GADA and IA-2A showed a sensitivity of 87.4% and was not appreciably improved by adding IAA; (ii) out of 31 adults who required insulin immediately or within the first two years of diagnosis, 41.9, 29.0, and 6.5% were positive for at least one, two or all three, and all three markers, respectively; GADA was the most prevalent (35.5%) and IA-2A the least represented (16.1%); (iii) 34 adult patients with slow evolution to insulin dependence showed a completely different profile: 5.9% were GADA positive and 23.5% were IAA positive and no double or triple positivity was observed as all patients were IA-2A negative; and (iv) 50 type 2 patients who had not required insulin treatment showed a low incidence of GADA (4%) as the only marker present. "
2. Glucose (Dextrose)FDA LinkGeneric
3. Blood Glucose (Blood Sugar)IBA
4. C-PeptideIBA
5. Insulin Glargine (Lantus)FDA Link
6. Streptozocin (Streptozotocin)FDA Link
7. AutoantibodiesIBA
8. Hypoglycemic Agents (Hypoglycemics)IBA
9. CarbohydratesIBA
10. Insulin Lispro (Humalog)FDA Link

Therapies and Procedures

1. Therapeutics
2. Glycemic Control
3. Islets of Langerhans Transplantation
4. Transplantation
5. Injections