Interleukin-10 (Interleukin 10)

A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.

Also Known As:

Networked: 12538 relevant articles (542 outcomes, 1592 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Müller, Werner: 21 articles (11/2014 - 11/2004)
2.	Roers, Axel: 19 articles (07/2015 - 11/2004)
3.	Flavell, Richard A: 18 articles (08/2015 - 02/2006)
4.	Volk, Hans-Dieter: 18 articles (01/2015 - 04/2002)
5.	Wynn, Thomas A: 18 articles (02/2012 - 03/2002)
6.	Saha, Bhaskar: 16 articles (09/2015 - 05/2004)
7.	Sartor, R Balfour: 15 articles (10/2015 - 11/2004)
8.	Teixeira, Mauro M: 15 articles (11/2014 - 04/2002)
9.	Milligan, Erin D: 15 articles (01/2014 - 03/2004)
10.	Zhang, Jian: 14 articles (01/2016 - 01/2003)

Related Diseases

1.	Infection 02/01/2012 - "Although Foxp3(+) regulatory CD4(+) T cells produce IL-10 during infection, highly activated IFN-γ(+) Th1 cells were shown to be the essential and sufficient source of IL-10 to guarantee protection against severe immune-mediated pathology. " 08/01/2007 - "This study evaluated associations between three single nucleotide polymorphisms in the IL10 promoter and clearance of low- or high-risk HPV infection in a cohort of 226 largely HIV-1-infected African-American adolescent females. " 09/15/2011 - "Ab4 infection resulted in a significant reduction of IL-10 responses in adult horses. " 12/23/2008 - "As a result, simultaneous blockade of IL-10 and PD-L1 was significantly more effective in restoring antiviral T-cell responses than blockade of either alone, and led to substantially enhanced control of an established persistent viral infection. " 06/01/1996 - "In vivo neutralization of IL-10 in BALB/c mice with an anti-IL-10 mAB during MoPn infection significantly increased the DTH response and enhanced clearance of MoPn. "
2.	Inflammation 01/01/2014 - "The use of a genetically engineered food-grade bacterium, such as Lactococcus lactis, secreting the anti-inflammatory cytokine IL-10 has been proven by many pre-clinical studies to be a successful therapy to treat colon inflammation. " 04/01/1998 - "Treatment with IL-10 resulted in a marked improvement in intestinal inflammation. " 02/01/2008 - "Treatment with allergen-modified-DC suppressed airway inflammation and Th2 responses, and increased IL-10 and IFN-gamma production and Foxp3(+) Tregs significantly; and eliminated the responses of CD4(+) T cells to allergen. " 01/01/2002 - "Fact, that IL-10 is produced by Th1 and that inhibits cytokine production by Th2 lymphocytes has led to the concept that IL-10 might be beneficial in mitigating allergic inflammation. " 10/01/1999 - "In conclusion, reducing the inflammatory response to SCI by systemic administration of IL-10 resulted in a significant reduction in neuronal damage, suggesting that targeting injury-induced inflammation may be an effective treatment strategy for acute SCI."
3.	Colitis 02/01/2014 - "These data demonstrate that chronic supplementation with a natural mineral extract selectively ameliorates spontaneous mild-moderate colitis in Il10(-/-) mice on a C57BL/6 J, but does not attenuate more moderate-severe colitis in BALB/c strain animals." 01/01/2010 - "The aim of this study was to determine if administration of cis-UCA would be effective in attenuating colitis and the possible role of IL-10. " 08/01/2004 - "This study investigates the therapeutic efficacy of an adenovirus encoding IL-10 (AdvmuIL-10) in the treatment of experimental colitis. " 12/01/2002 - "This study investigates the therapeutic efficacy of an adenoviral vector encoding IL-10 (AdvmuIL-10) in experimental colitis. " 02/01/2009 - "We hypothesized that interleukin-10 delivery to the distal gastrointestinal tract using a unique delivery vehicle may serve as a novel therapeutic for the treatment of experimental colitis. "
4.	Neoplasms (Cancer) 12/01/2015 - "In this study, we provided evidence that MSCs derived from cervical tumors (CeCa-MSCs) cocultured with CeCa cells induced significant expression of TGF-β1 and secretion of IL-10 by CeCa cells compared to MSCs derived from the normal cervix (NCx-MSCs) and normal bone marrow (BM-MSCs; gold standard). " 01/01/2011 - "Importantly, we demonstrate that the role of IL-10 is critical, and not redundant with other immunosuppressive molecules, to in vivo tumor progression: blockade of the IL-10 signaling network results in alleviation of MDSC-mediated immunosuppression, altered T cell phenotype and activity, and improved survival. " 09/01/2015 - "Functional studies demonstrated that some factors, including IL10 and IL32-gamma, induced PD-L1 expression on monocytes but not tumor cells. " 06/01/2015 - "Previous studies investigated the associations of interleukin-10 (IL-10) polymorphisms with different types of cancer, indicating an influence on cancer risk. " 01/01/2015 - "We searched PubMed and EBSCO for studies in evaluating the association of IL-10 expression-in serum and clinical outcome in cancer patients. "
5.	Necrosis 01/01/2008 - "The two fractions caused a significant reduction in production of tissue necrosis factor-alpha and an increase in interleukin 10 (IL-10)." 10/01/2003 - "Interleukin 10 gene transfection of donor lungs ameliorates posttransplant cell death by a switch from cellular necrosis to apoptosis." 10/01/2004 - "In this study, we investigated whether strain CR1 caused apoptosis or necrosis of macrophages after its inoculation into mice peritoneal cavity, and whether this correlated with the secretion of IL-10. " 09/15/2003 - "In this study, we show that IL-10 knockout mice infected with this parasite develop extensive areas of coagulative necrosis in the liver, and newborn larvae are required for lesion formation. " 03/01/2003 - "In in vitro cell cultures, there was reduced tumour necrosis factor-alpha and interleukin-10 production at week 26, with the latter persistent throughout the study period. "

Related Drugs and Biologics

1.	Cytokines
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Interleukin-6 (Interleukin 6)
4.	Interleukin-4 (Interleukin 4)
5.	Interleukin-12 (IL 12)
6.	Messenger RNA (mRNA)
7.	Interferon-gamma (Interferon, gamma)
8.	Interleukins
9.	Interleukin-10 (Interleukin 10)
10.	Interleukin-2 (IL2)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Aftercare (After-Treatment)
3.	Immunotherapy
4.	Oral Administration
5.	Drug Therapy (Chemotherapy)