Radiation Injuries (Radiation Sickness)

02/01/1984 - "The efficacy of WR-2721 pretreatment against radiation injury to the growing kidney was evaluated in the weanling mouse. "
06/01/1986 - "Clinical study of the radioprotective effects of Amifostine (YM-08310, WR-2721) on chronic radiation injury."
07/01/2006 - "Radiation injury to the rectum and amifostine."
01/01/2003 - "Amifostine protects both mesenchymal and hematopoietic progenitors against radiation injury, though the level of protection appears to be dependent upon the sensitivities of these progenitor cells to radiation. "
05/01/1994 - "[The effect of gammaphos on the course and outcome of surgical treatment in combined radiation injuries in pigs]."

04/01/1997 - "Effect of enteral glutamine on intestinal permeability and bacterial translocation after abdominal radiation injury in rats."
01/01/1994 - "Comparison of diets with and without the added glutamine showed significant protection of the intestine from radiation injury. "
01/01/1994 - "Protection from radiation injury by elemental diet: does added glutamine change the effect?"
09/01/1992 - "Therefore, intravenous glutamine supplementation failed to accelerate recovery of small-bowel morphology in this model of combined surgical and radiation injury."
09/01/1992 - "Intravenous glutamine fails to improve gut morphology after radiation injury."

03/01/1951 - "Relation of clearance and distribution of injected glutathione to protection against radiation injury."
09/01/2007 - "Moreover, we show that SQ20B are protected against radiation injury through a fivefold upper level of endogenous glutathione compared to SCC61. "
05/01/2002 - "In addition, the effects of exogenous glutathione (GSH) against radiation injury in rat livers were investigated. "
05/01/1992 - "The prophylactic effect of glutathione (GSH) on radiation injury in rat parotid glands was investigated. "
09/01/1987 - "[Effect of glutathione on the course of radiation sickness with a marked gastrointestinal syndrome and the effectiveness of parenteral feeding in an experiment]."

07/01/2008 - "These data suggest that genistein is protective against a range of radiation injuries."
11/01/2009 - "We previously demonstrated that a single subcutaneous (sc) administration of genistein at a non-toxic dose provided protection against acute radiation injury and that the radioprotective effects were associated with multilineage, hematopoietic progenitor cell recovery. "
11/01/2003 - "administration of the flavonoid genistein at non-toxic doses provides protection against acute radiation injury."
07/01/2008 - "Thirty-day survivals after 7.75 Gy were: NR 23%, VR 53%, and GR 92%, indicating significant protection from acute radiation injury by genistein. "
02/01/2013 - "These data suggest that genistein and captopril protect the hematopoietic system from radiation injury via independent mechanisms."

10/01/1992 - "This review presents the roles of some essential metalloelement-dependent enzymes in the maintenance and function of tissues and their responses to radiation injury and gives an account of the observed effects of nontoxic doses of essential metalloelement compounds on protection against radiation damage and its recovery. "
06/01/1964 - "[STUDIES ON THE DISTRIBUTION AND ACTIVITY OF SOME ENZYMES IN THE SMALL INTESTINE MUCOSA DURING DIFFERENT STAGES OF ACUTE RADIATION INJURY]."
01/01/1963 - "[HISTOCHEMICAL STUDIES ON THE BEHAVIOR OF ENZYMES IN THE LUNGS IN ACUTE RADIATION INJURY AND AFTER LOCAL ROENTGEN IRRADIATION]."
01/01/1961 - "[Histochemical studies on oxidative enzymes in lung tissue in radiation injury induced by incorporated radioactive substances]."
01/01/2001 - "These chelates may be useful in facilitating de novo syntheses of essential metalloelement-dependent enzymes required to repair radiation injury. "

08/14/1961 - "[Studies on the role of 5-hydroxytryptamine (serotonin) in the pathogenesis of hematological disorders during the course of acute irreversible radiation sickness]."
09/01/1960 - "[Study of the role of serotonin (5-hydroxytryptamine) in the pathogenesis of acute radiation sickness. "
03/01/1959 - "[Study of the role of serotonin (5-oxytriptamine) in the pathogenesis of acute radiation sickness. "
07/01/1973 - "[Dynamics of changes in serotonin and thrombocyte count in rat blood during the development of acute radiation sickness]."
05/01/1972 - "[Serotonin consumption by thrombocytes in acute radiation sickness]."

07/01/2000 - "Further studies should be performed to explore the role of other cytokines in the development of radiation injury. "
06/01/1991 - "This report confirms and extends previous studies concerning the potential of cytokines in prevention or therapy of lethal radiation injury."
06/01/2010 - "Rationale and recommendations for treatment of radiation injury with cytokines."
09/01/2004 - "Radiation-induced lung damage implies the induction of numerous cytokines which form the basis for the multicellular interactions of the inflammatory and fibrogenic processes associated with radiation injury. "
12/01/2002 - "Results suggest that a new paradigm is evolving for the prophylaxes of radiation injuries, based on use of newly identified, nontoxic, broad-spectrum prophylactic agents whose protective action may be leveraged by subsequent postexposure use of cytokines with organ-specific reparative functions."

07/01/1990 - "Cystamine given to rats prior to irradiation with a dose of 8 Gy (LD77/30) ameliorates significantly the severity of radiation sickness and restores spontaneous motor activity by the time of clinical recovery. "
08/01/1960 - "A trial of cystamine in radiation sickness."
05/01/1985 - "The polydeoxyribonucleotide (PDN) level in leukocytes of peripheral blood of rats treated with cystamine adequately reflects the severity and outcome of radiation sickness. "
01/01/1981 - "[Protein metabolic indices in radiation sickness and the administration of cystamine]."
01/01/1977 - "Experiments were performed on the third day after the administration of cystamine, since the author's previous investigations showed that the protective action of cystamine in radiation sickness was strongest at this time. "

09/01/2011 - "To protect against radiation injury from extravasation of therapeutic radionuclides, test administration of a small (99m)Tc dose with probe monitoring of comparable sites in both upper extremities appears to be an effective preventive measure."
06/01/2010 - "The Radiation Countermeasures Program at NIAID has established a broad research agenda focused on the development of new medical products to mitigate and treat acute and long-term radiation injury, promote the clearance of internalized radionuclides, and facilitate accurate individual dose and exposure assessment. "
03/01/1975 - "[Study and comparative evaluation of radiation injuries and recovery processes in the large intestine exposed to rare-earth radionuclides]."
11/01/1959 - "[Roentgenological observations in studies of the lungs of animals with acute radiation sickness developing after administration of radioactive isotopes]."
09/30/2010 - "Radiation injuries are usually caused by radioactive isotopes in industry. "

01/01/2012 - "It was shown in this experimental model that melatonin has protective effects against radiation injury to kidneys."
04/01/2014 - "It was found that replacement of drinking water with melatonin solution (5 mg/liter) did not reduce the amount of fluid intake throughout the period of acute radiation injury. "
04/01/2014 - "Therapeutic effect of long-term melatonin treatment on the course and fatal outcome of modeled acute radiation sickness."
01/01/1995 - "On the contrary, in the phase of developed radiation injury the signs of increased melatonin synthesis were observed on days 3 and 4 after the exposure (Kassayová et al. 1993a). "
03/01/2002 - "Since there are no existing safe and effective treatments of radiation injury, studies of essential metalloelement chelates and combinations of them, as well as combinations of them with existing radioprotectant aminothiols, Ca-channel blockers, acyl Melatonin homologs, substituted anilines, and curcumin as radioprotectants seem worthwhile."

04/01/2007 - "Clinical development of pharmacologic approaches to mitigation or treatment of chronic radiation injuries could lead to significant improvement in survival and quality of life for radiotherapy patients and for victims of radiation accidents or nuclear terrorism."
01/01/2003 - "Clinical development of pharmacological approaches to modification of chronic radiation injuries could lead to significant improvement in survival and quality of life for radiotherapy patients and for victims of radiation accidents or nuclear terrorism."
07/01/1985 - "Radiotherapy promises to be a useful technique, since information regarding improved survival, alleviation of symptoms, and reduced radiation injury has become widely available. "
03/01/2005 - "This study was to analyze the MRI characteristics of radiation injury in brain stem and cervical spinal cord of patients with NPC after radiotherapy. "
06/01/2001 - "Despite subtle differences between the chick and mammalian growth plates, further studies should provide an enhanced understanding of the mechanism(s) of radiation injury to the growth plate, as well as possibilities for new therapeutic strategies to protect the growing skeleton from the detrimental effects of radiotherapy."

11/01/2000 - "Long-term oral administration of ASA gave only a modest, non-significant reduction of renal radiation injury after clinically relevant fractionated irradiation schedules."
09/01/1992 - "These findings suggest that, after X-ray radiation injury of the intestinal mucosa, the oral administration of the elemental diet containing 2% glutamine improved glutamine metabolism of the body, promoted the proliferation of jejunal epithelium, accelerated the recovery of the mucosal mass and the morphology of villi, and then contributed to maintaining the barrier function of the intestine from an early stage after the injury. "
04/01/2010 - "Antioxidants mitigate radiation-induced lethality when started soon after radiation exposure, a delivery time that may not be practical due to difficulties in distribution and because the oral administration of such agents may require a delay beyond the prodromal stage of the radiation syndrome. "
01/01/1960 - "[Experimental data on the investigation of the effect of chlortetracycline for oral administration in various forms of complex therapy of acute radiation sickness]."
01/01/1955 - "[Oral administration of cystamine in radiation sickness]."

01/01/1957 - "Protection against radiation injury by heterologous tissue transplants."
05/15/2015 - "Therapeutic potential of gingival fibroblasts for cutaneous radiation syndrome: comparison to bone marrow-mesenchymal stem cell grafts."
01/01/2007 - "A successful transplant of stem cells and subsequent reduction in radiation-induced complication may open the road to completely new strategies in cutaneous radiation syndrome therapy."
01/01/2007 - "Human mesenchymal stem cells favour healing of the cutaneous radiation syndrome in a xenogenic transplant model."
12/15/2000 - "Although application of the strategy may be limited by the possibility of radiation injury, the results are consistent with the paradigm that we have proposed to explain organ-induced graft acceptance, tolerance, and chronic rejection."

07/01/1994 - "[Experimental study of therapeutic efficacy of plasmapheresis in acute radiation injury]."
07/01/1994 - "In experiments with dogs exposed to 2.9 Gy (LD80/45) it was found that plasmapheresis treatment 4-6 h after irradiation reduce the severity of the radiation sickness clinical manifestations and post-radiation toxemia thus increasing the rate of animal survival up to 60%. "

02/01/1964 - "[ON THE INFLUENCE OF ANEMIC BLOOD PLASMA ON THE EFFICACY OF BONE MARROW TRANSPLANTATION IN ACUTE RADIATION SICKNESS]."
07/01/2001 - "Radiation injury in humans was a major stimulus for research in bone marrow transplantation. "
12/01/1990 - "Therapy of such patients should be developed along the following lines: 1) prevention and therapy of infectious complications: 2) blood cell substitution therapy; 3) bone marrow transplantation; 4) detoxicating therapy; 5) correction of water-electrolyte metabolism; 6) therapy of local radiation injuries."
07/01/1970 - "[Oxidative phosphorylation in spleen mitochondria in acute radiation injury treated by bone marrow transplantation]."
02/01/1969 - "[Dependence of the effect of bone marrow transplantation in radiation sickness upon the quantity of cells transplanted]."