Genistein

An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.

Also Known As:

Networked: 1910 relevant articles (155 outcomes, 420 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sarkar, Fazlul H: 45 articles (01/2014 - 01/2002)
2.	Li, Yiwei: 24 articles (01/2014 - 01/2002)
3.	Kucuk, Omer: 22 articles (11/2013 - 06/2002)
4.	Helferich, William G: 19 articles (12/2015 - 05/2002)
5.	Lamartiniere, Coral A: 18 articles (03/2014 - 01/2002)
6.	Doerge, Daniel R: 17 articles (08/2015 - 05/2002)
7.	Squadrito, Francesco: 15 articles (09/2015 - 10/2002)
8.	Bignon, Yves-Jean: 15 articles (04/2015 - 02/2006)
9.	Banerjee, Sanjeev: 15 articles (01/2014 - 10/2005)
10.	Bitto, Alessandra: 14 articles (09/2015 - 04/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "Proliferation of different human cancer cell lines, antimicrobial activity and angiogenesis behavior was analyzed in order to see if complexation has a beneficial effect for any of the above mentioned activities and if so, which of the three CDs is the most suitable for the incorporation of genistein, and which may lead to future improved pharmaceutical formulations. " 05/01/2005 - "Administration of 250 and 500 mg genistein/kg AIN-76A improved survival (P = 0.008 and P = 0.005, respectively) and reduced mean weight of prostates with poorly differentiated cancer (PD) (P < 0.001), as well as the mean weight of periaortic lymph nodes (LN), although the latter was not significant. " 03/01/2005 - "Treatment of ovariectomized Min/+ (Min/+ OX) mice with genistein resulted in a non-significant reduction in tumor number. " 10/01/2004 - "Genistein combined with radiation caused a significantly greater inhibition of primary tumor growth (87%) compared with genistein (30%) or radiation (73%) alone. " 01/01/2015 - "Our results also suggest that genistein may be an effective agent for overcoming chemoresistance in cancers with dysfunctional Bax and p53. "
2.	Breast Neoplasms (Breast Cancer) 08/01/2000 - "Dietary intake of genistein in combination with EPA may be beneficial for breast cancer control." 08/01/2000 - "We review data relevant to attempts to determine whether soy, and more specifically genistein, is a dietary component that may help to explain the dramatic disparity in breast cancer risk among these populations." 06/28/2005 - "Genistein and DHA, in particular, may augment the efficacy of statins, increasing the potential for use of these drugs in adjuvant therapy for breast cancer." 07/01/2007 - "Our research may provide a novel approach for the prevention and/or treatment of TAM insensitive/resistant human breast cancer, and warrants further in vivo studies to verify the efficacy of genistein and TAM combination on the growth of ER+/HER2-overexpressing breast tumors and to elucidate the in vivo mechanisms of synergistic actions." 08/01/2009 - "The results show that LTGT results in a down-regulation of the PI3-K/Akt signalling pathway and may be a mechanism through which genistein could offer protection against breast cancer."
3.	Prostatic Neoplasms (Prostate Cancer) 06/01/2015 - "Our study suggested that high concentration of plasma genistein level may contribute to the low incidence of prostate cancer in Chinese population." 06/01/2015 - "There were studies proving that high-dietary intake of genistein may relate to the low morbidity and mortality of prostate cancer (PCa) in the Asian population. " 01/01/2012 - "We undertook the present study to investigate the effects of genistein on the epigenome of prostate cancer cells and to discover novel combination approaches of other compounds with genistein that might be of translational utility. " 03/05/2010 - "In this study, we investigated whether cell survival could be suppressed by a combination of the dispersion of lipid raft microdomains and treatment with genistein, a well-known potential isoflavone, in LNCaP prostate cancer cells. " 01/01/2010 - "Genistein showed similar effects to that of 5Aza-C, which is currently undergoing phase 2 clinical trials as a treatment for prostate cancer. "
4.	Osteoporosis 01/01/2015 - "Apium extract and Genistein impeded the development of osteoporosis (significant differences were shown for BMC and BMD levels in drug vs. vehicle treated rats) and improved bone histology and histological score. " 01/14/2014 - "Genistein, structurally similar to 17β-oestradiol, is a phyto-oestrogen that may be beneficial for treating osteoporosis. " 11/01/2006 - "Pharmacological studies of the large-scaled purified genistein from Huaijiao (Sophora japonica-Leguminosae) on anti-osteoporosis." 01/01/2014 - "Our findings suggest that genistein may be used to treat and prevent osteoporosis in postmenopausal women with OSAHS." 06/01/2009 - "Clinical evidence suggests a role for genistein (GEN) aglycone in the prevention of osteoporosis. "
5.	Fibrosis (Cirrhosis) 12/01/2015 - "Genistein improved cardiac function and inhibited cardiac fibrosis in response to pressure overload. " 02/27/2013 - "This study examined the effect of genistein isolated from Hydrocotyle sibthorpioides on chronic alcohol-induced hepatic injury and fibrosis. " 12/01/2015 - "Genistein may have potential as a novel agent for prevention and therapy of cardiac disorders associated with fibrosis. " 12/01/2015 - "Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice." 08/30/2013 - "Genistein has the ability to block the biomarker for renal transdifferentiation and epithelial-to-mesenchymal transition, α-SMA, following PTH treatment and inhibit CTGF expression in human renal tubular epithelial cells; these might be important modes of actions that contribute to genistein anti-fibrogenic effects and may have great implications for its potential in clinical treatment of renal interstitial fibrosis."

Related Drugs and Biologics

1.	daidzein
2.	Isoflavones
3.	Phytoestrogens (Phytoestrogen)
4.	Hormones
5.	Insulin (Novolin)
6.	Quercetin
7.	Estrogens (Estrogen)
8.	Protein-Tyrosine Kinases (Tyrosine Kinase)
9.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Chemoprevention
4.	Therapeutics
5.	Ovariectomy (Oophorectomy)