Abstract |
Male Sprague-Dawley rats housed in individual metabolic cages received total parenteral nutrients via chronic indwelling internal jugular catheters to determine whether supplementing parenteral nutrition with glutamine would accelerate recovery of small-bowel morphology after abdominal radiation. After recovering from catheter insertion for 3 days they received either 1000 cGy gamma radiation to the abdomen only or no radiation and immediately thereafter received isonitrogenous and isocaloric intravenous solutions containing either 0% or 2% glutamine at 1.58 mL/h for the next 5 days. Intestinal segments were then assayed for whole-bowel deoxyribose nucleic acid content and villus height. Irradiation caused a 40% decrement in these parameters, which were not restored by glutamine supplementation. Therefore, intravenous glutamine supplementation failed to accelerate recovery of small-bowel morphology in this model of combined surgical and radiation injury.
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Authors | T E Scott, J R Moellman |
Journal | JPEN. Journal of parenteral and enteral nutrition
(JPEN J Parenter Enteral Nutr)
1992 Sep-Oct
Vol. 16
Issue 5
Pg. 440-4
ISSN: 0148-6071 [Print] United States |
PMID | 1433777
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Animals
- DNA
(analysis)
- Glutamine
(administration & dosage, therapeutic use)
- Injections, Intravenous
- Intestines
(injuries, pathology, radiation effects)
- Male
- Parenteral Nutrition, Total
- Radiation Injuries, Experimental
(pathology, therapy)
- Rats
- Rats, Sprague-Dawley
- Time Factors
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