Ototoxicity

Damage to the EAR or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.

Also Known As:

Cochlear Toxicities, Drug-Induced; Cochlear Toxicities, Drug-Related; Cochlear Toxicity, Drug-Induced; Cochlear Toxicity, Drug-Related; Cochleotoxicities, Drug-Induced; Cochleotoxicities, Drug-Related; Cochleotoxicity, Drug-Induced; Cochleotoxicity, Drug-Related; Drug Induced Cochlear Toxicity; Drug Induced Cochleotoxicity; Drug Induced Otological Toxicity; Drug Induced Ototoxicity; Drug Induced Vestibular Toxicity; Drug Induced Vestibulotoxicity; Drug Related Cochlear Toxicity; Drug Related Cochleotoxicity; Drug Related Otological Toxicity; Drug Related Ototoxicity; Drug-Induced Cochlear Toxicities; Drug-Induced Cochleotoxicities; Drug-Induced Otological Toxicities; Drug-Induced Ototoxicities; Drug-Induced Vestibular Toxicities; Drug-Induced Vestibulotoxicities; Drug-Related Cochlear Toxicities; Drug-Related Cochleotoxicities; Drug-Related Otological Toxicities; Drug-Related Ototoxicities; Otological Toxicities, Drug-Induced; Otological Toxicities, Drug-Related; Otological Toxicity, Drug-Induced; Otological Toxicity, Drug-Related; Ototoxicities; Ototoxicities, Drug-Induced; Ototoxicities, Drug-Related; Ototoxicities, Radiation-Induced; Ototoxicity, Drug-Induced; Ototoxicity, Drug-Related; Ototoxicity, Radiation-Induced; Radiation Induced Ototoxicity; Radiation-Induced Ototoxicities; Toxicity, Otological; Vestibular Toxicities, Drug-Induced; Vestibular Toxicity, Drug-Induced; Vestibulotoxicities, Drug-Induced; Vestibulotoxicity, Drug-Induced; Auditory Toxicity; Drug-Induced Cochlear Toxicity; Drug-Induced Cochleotoxicity; Drug-Induced Otological Toxicity; Drug-Induced Ototoxicity; Drug-Induced Vestibular Toxicity; Drug-Induced Vestibulotoxicity; Drug-Related Cochlear Toxicity; Drug-Related Cochleotoxicity; Drug-Related Otological Toxicity; Drug-Related Ototoxicity; Otological Toxicity; Radiation-Induced Ototoxicity

Networked: 3926 relevant articles (266 outcomes, 847 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hearing Loss (Hearing Impairment)
2.	Neoplasms (Cancer)
3.	Head and Neck Neoplasms (Head and Neck Cancer)
4.	Wounds and Injuries (Trauma)
5.	Inflammation (Inflammations)

Experts

1.	Rybak, Leonard P: 35 articles (11/2021 - 06/2002)
2.	Steyger, Peter S: 26 articles (12/2021 - 01/2009)
3.	Daniel, Sam J: 25 articles (03/2017 - 08/2005)
4.	Ding, Dalian: 22 articles (01/2022 - 02/2002)
5.	Mukherjea, Debashree: 22 articles (01/2022 - 04/2007)
6.	Ramkumar, Vickram: 22 articles (01/2022 - 05/2004)
7.	Im, Gi Jung: 21 articles (12/2016 - 05/2007)
8.	Park, Raekil: 20 articles (01/2018 - 09/2007)
9.	Salvi, Richard: 19 articles (01/2022 - 11/2004)
10.	Schacht, Jochen: 19 articles (01/2019 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ototoxicity:

1.	Cisplatin (Platino)FDA LinkGeneric 09/01/2023 - "There are a number of natural products or their derivatives that show excellent protection against cisplatin ototoxicity in preclinical studies. " 12/01/2016 - "LA showed a significantly more effective protection against cisplatin-induced ototoxicity compared to that shown by GSH (85.4% vs. 73.1% cell viability). " 03/01/2016 - "Significant protection against cisplatin-induced ototoxicity was seen in groups III and IV compared with group II (p < 0.05). " 01/01/2016 - "Development of Cell-Based High-Throughput Chemical Screens for Protection Against Cisplatin-Induced Ototoxicity." 05/01/2013 - "The cumulative cisplatin dose <400 mg/m should be beneficial in order to ameliorate ototoxicity."
2.	AminoglycosidesIBA 07/01/2012 - "Aminoglycosides are highly effective against bacteria but have serious side-effects including ototoxicity and nephrotoxicity. " 01/01/2003 - "Clinically, increased levels of SOD or SOD mimetics might provide significant protection against aminoglycoside ototoxicity." 06/22/1990 - "Several experimental studies support a once-daily dosing regimen for aminoglycosides (comparable or better efficacy with less ototoxicity and nephrotoxicity). " 02/10/1996 - "Once daily administration of aminoglycosides in patients without pre-existing renal impairment is as effective as multiple daily dosing, has a lower risk of nephrotoxicity, and no greater risk of ototoxicity. " 02/01/1980 - "Utilizing information about aminoglycoside pharmacokinetics, the susceptibility of infecting pathogens to aminoglycosides, and risk factors for ototoxicity, physicians can attempt to optimize the administratioin of an aminoglycoside to maximize the therapeutic efficacy and to minimize the risk of ototoxicity. "
3.	Gentamicins (Gentamicin)FDA LinkGeneric 02/01/2022 - "The study intended to explore acupuncture's protective effects and mechanism of treatment in addressing ototoxicity induced by gentamicin (GM) in aged mice. " 01/25/2017 - "BACKGROUND The aim of this study was to investigate the protective effects of acupuncture against gentamicin-induced ototoxicity and explore the possible protective role of neurotrophin-3 (NT-3). " 04/24/2019 - "SkQR1 also provides auditory protective effects against gentamicin-induced ototoxicity. " 01/25/2017 - "Protective Effects of Acupuncture Against Gentamicin-Induced Ototoxicity in Rats: Possible Role of Neurotrophin-3." 12/11/2011 - "We previously reported that 17β-estradiol (βE2) had protective effects against gentamicin (GM) ototoxicity in the cochlea. "
4.	AntioxidantsIBA 12/01/2016 - "Garlic with its intrinsic antioxidant activity may prove beneficial in prevention from ototoxicity. " 02/01/2012 - "Garlic, with its intrinsic antioxidant activity, may prove beneficial in prevention of ototoxicity. " 06/01/2023 - "There are studies in the literature conducted with various antioxidant substances to protect and/or prevent ototoxicity. " 01/01/2017 - "While a very wide variety of antioxidants with different characteristics and intracellular targets exist, most ototoxicity studies have focused upon one or a few well-characterized compounds. " 01/01/2022 - "The antioxidant AVN-C exerts a strong protective effect against MTX-induced ototoxicity and preserved the inner ear structures (synapses, neurons, and OHCs) from MTX-induced damage. "
5.	Amikacin (A.M.K)FDA LinkGeneric 10/01/2016 - "The objectives of this study were to identify the amikacin dosage regimens and drug concentrations consistent with good outcomes and to determine the drug exposures related to nephrotoxicity and ototoxicity. " 01/01/2018 - "Therapeutic and protective effects of autologous serum in amikacin-induced ototoxicity." 07/01/2017 - "FoxO3a plays a key role in the protective effects of pomegranate peel extract against amikacin-induced ototoxicity." 11/01/2012 - "The results showed that PTX has protective effects on hearing functions in amikacin-induced ototoxicity in rats." 10/28/2022 - "The purpose of this study was to evaluate the effects of once daily (OD) or every 48 hours (every-48-h) administration of amikacin (AMK) on renal function and ototoxicity in neonates. "
6.	Acetylcysteine (Siran)FDA LinkGeneric 07/01/2004 - "This study investigated a new model for CDDP ototoxicity in the rat, and tested the potential chemoprotective effect of administering N-acetylcysteine (NAC) before giving CDDP. " 08/01/2018 - "l-N-acetylcysteine protects outer hair cells against TNFα initiated ototoxicity in vitro." 08/01/2007 - "N-Acetylcysteine in the prevention of ototoxicity." 12/01/2011 - "Protective effect of N-acetylcysteine from drug-induced ototoxicity in uraemic patients with CAPD peritonitis." 04/01/2009 - "The present study analysed, in an animal experimental model, the time course of the pathogenic mechanisms of noise-induced cochlear damage and the efficacy of the antioxidant drug N-acetylcysteine in reducing noise ototoxicity. "
7.	Methionine (L-Methionine)FDA Link 01/01/2008 - "These results suggest the potential usefulness of d-methionine in protecting from noise-induced ototoxicity." 04/01/2001 - "To test the effectiveness of local delivery, of L-methionine (L-Met) as an otoprotective agent against CDDP ototoxicity, we used a rat model of a highly metastatic breast cancer tumor, i.e. " 01/01/2022 - "Objective: This exploratory Phase 2 clinical trial is the first determining safety and efficacy of oral D-methionine (D-met) in reducing cisplatin-induced ototoxicity.Design" 10/01/1999 - "L- and D- methionine provide equivalent long term protection against CDDP-induced ototoxicity in vivo, with partial in vitro and in vivo retention of antineoplastic activity." 03/01/1997 - "D-methionine (D-met) has been demonstrated to provide protection against cisplatin's nephrotoxicity in vivo and ototoxicity in vitro. "
8.	sodium thiosulfate FDA Link 07/07/2023 - "Reevaluation of sodium thiosulfate otoprotection using the consensus International Society of Paediatric Oncology Ototoxicity Scale: A report from the Children's Oncology Group study ACCL0431." 01/01/2019 - "Brock criteria grade 1 or higher) was lower with sodium thiosulfate (combined asymptomatic and symptomatic ototoxicity: RR 0.52, 95% CI 0.33 to 0.81; symptomatic ototoxicity only: RR 0.39, 95% CI 0.19 to 0.83). " 11/01/2014 - "Further investigation of the administration and systemic mechanism of absorption of sodium thiosulfate as a potential protection against cisplatin ototoxicity is needed to confirm these findings." 03/01/2001 - "The purpose of this study was to determine whether delayed administration of sodium thiosulfate (STS), given after BBB closure, provided protection against carboplatin ototoxicity. " 10/01/2020 - "Sodium thiosulfate effectively inactivates cisplatin through covalent binding and may provide protection against cisplatin-induced ototoxicity. "
9.	Carboplatin (JM8)FDA LinkGeneric 01/01/2017 - "Previous studies have shown limited information on the incidence and severity of carboplatin-induced ototoxicity and the used audiologic methods. " 10/01/2004 - "The aim of this study was to analyse carboplatin-induced ototoxicity in a recent study trial. " 01/01/1995 - "Studies in many animal species have indicated that carboplatin ototoxicity is expressed as damage to cochlear outer hair cells. " 03/01/1994 - "In the present study, the mechanism of ototoxicity was investigated by comparing two different routes of carboplatin administration. " 01/01/2017 - "We observed no clear effect between carboplatin administration in young children and clinical significant ototoxicity in the long term. "
10.	Dexamethasone (Maxidex)FDA LinkGeneric 01/01/2023 - "The present study examined the preconditioning effect of dexamethasone (DEX) on TNF-α-induced ototoxicity in mouse auditory hair cells (HEI-OC1) and cochlear explants. " 10/01/2017 - "Dexamethasone at the dose of 15 mg/kg/day partially protected against CDDP-induced ototoxicity, based on functional evaluation by brainstem evoked response audiontry (BERA) and morphological evaluation by optical microscopy. " 01/01/2017 - "Anti-apoptotic effect of dexamethasone in an ototoxicity model." 01/01/2017 - "Effects of Intratympanic Dexamethasone on High-Dose Radiation Ototoxicity In Vivo." 05/01/2013 - "Systemic dexamethasone administration in a guinea pig model did not provide significant protection against cisplatin-induced ototoxicity. "

Therapies and Procedures

1.	Therapeutics 03/28/2013 - "This important modification to our drug delivery system has the ability to deliver therapy to the inner ear until desired effect is achieved and to stop this process when side effects or treatment-related ototoxicities start to occur, providing a novel and salient approach for safe and effective delivery to the inner ear." 10/01/2015 - "The primary predictors of ototoxicity on CART analyses were cumulative days of therapy, followed by cumulative area under the concentration-time curve (AUC), which improved on the primary predictor by 87%. " 08/01/2011 - "Overall, continuous infusion of PLADO therapy resulted in survival rates consistent with those observed in intergroup studies, but rates of chronic cardiac and ototoxicity did not differ sufficiently from those observed after shorter infusion of PLADO therapy to warrant the use of continuous infusions." 01/01/2008 - "While descriptive studies consider possible ototoxicity associated with antiretroviral therapy, this possible adverse effect was not related to the antiretroviral therapy in this study. " 10/31/2023 - "Clinical strategies to limit ototoxicity include identifying patients at risk, monitoring drug concentrations, performing serial hearing assessments and switching to less ototoxic therapy. "
2.	Drug Therapy (Chemotherapy) 10/01/2022 - "Furthermore, this study aimed to explore patient awareness surrounding chemotherapy-induced inner ear damage, known as ototoxicity, and assess what support they had been offered. " 11/14/2019 - "This study aimed to assess the knowledge regarding pharmacotherapy-induced ototoxicity amongst final year, medicine, pharmacy, audiology and nursing students across South African universities. " 12/15/2004 - "The results of the present study show that blocking a critical step in apoptosis may be a useful strategy to prevent harmful side effects of CDDP ototoxicity in patients having to undergo chemotherapy." 10/18/2023 - "Both questionnaires were used to collect information on awareness of chemotherapy-induced ototoxicity. " 01/01/2023 - "Here, we review therapeutic approaches to mitigating ototoxicity related to chemotherapy. "
3.	Radiotherapy 01/01/2003 - "The aim of this study was to evaluate the long-term visual and auditory toxicity in patients treated with radiotherapy for NPC. " 06/03/2023 - "The metafor-package was employed to compare ototoxicity rates in individuals receiving radiotherapy. " 06/03/2023 - "To provide optimal care for these cancer survivors and minimize subsequent complications, it is crucial to comprehend the relationship between radiotherapy and ototoxicity. " 06/03/2023 - "The relevance of ototoxicity induced by radiotherapy." 10/01/2014 - "Radiotherapy-enhanced ototoxicity in elderly."
4.	Injections 05/01/2021 - "With current guidelines by World Health Organisation on replacement of second-line injectable by oral regimens while treating patients with MDR-TB, it is expected to address ototoxicity and related issues." 01/01/2021 - "In vivo, the hearing of mice that received ALA-NP injections into the middle ear cavity was better preserved after induction of ototoxicity than in control animals. " 01/01/2021 - "However, ototoxicity induced by the injectable is a concern. " 01/01/2020 - "Until evidence shows that other drugs can assure at least the same strong resistance preventing activity of the injectables, it seems wise to continue using this group of drugs, and adapt the regimen if any ototoxicity is detected." 01/01/2019 - "Data are scarce on injectable-induced nephrotoxicity and ototoxicity in Ethiopian MDR-TB patients. "
5.	Intratympanic Injection 10/01/2013 - "These findings suggest that KRG including gRb1 component protects against vestibular/hearing dysfunction by inhibiting apoptotic pathways when ototoxicity is induced by unilateral intratympanic injection with GM in rats." 07/01/1999 - "Little experimental data exist that directly demonstrate the relative cochlear and vestibular ototoxicity resulting from transtympanic administration of SM compared to GM. " 01/01/2023 - "For the in vivo ototoxicity study, a single intratympanic injection of MI503 (50 or 500 μM) or phosphate-buffered saline (n = 4 each) was done in the ICR mice. " 12/01/2018 - "To research the ototoxicity of xylitol after intratympanic injection in mice ear model. " 01/01/2016 - "In the first step, ototoxicity was evaluated with 7 male albino guinea pigs (GPs) via auditory brainstem responses (ABR) before and 4 weeks after unilateral intratympanic injection of CDH and saline solution contralaterally. "