dihydrotanshinone I

extracted from Radix Salviae

Also Known As:

(-)-dihydrotanshinone I; (1R)-1,6-dimethyl-1,2-dihydrophenanthro(1,2-b)furan-10,11-dione; 15,16-dihydrotanshinone I; 15,16-dihydrotanshinone-I; dihydrotanshinone-I

Networked: 56 relevant articles (6 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - dihydrotanshinone I: 56
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        dihydrotanshinone I: 56
- Quinones: 434
  - dihydrotanshinone I: 56
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - dihydrotanshinone I: 56

Experts

1.	Liang, Yu-Chih: 4 articles (08/2015 - 12/2007)
2.	Jin, Xuejun: 3 articles (10/2015 - 07/2007)
3.	Lee, Jung Joon: 3 articles (10/2015 - 07/2007)
4.	Suk, Fat-Moon: 3 articles (08/2013 - 12/2007)
5.	Li, Ping: 2 articles (01/2021 - 09/2016)
6.	Shi, Wei: 2 articles (01/2021 - 01/2021)
7.	Yang, Hua: 2 articles (01/2021 - 09/2016)
8.	Zhang, Lin: 2 articles (10/2020 - 11/2015)
9.	Chen, Jie: 2 articles (01/2019 - 01/2019)
10.	Chen, Xi: 2 articles (01/2019 - 01/2019)

Related Diseases

1.	Uterine Cervical Neoplasms (Cancer of the Cervix) 04/01/2012 - "The aim of this study was to investigate the effect of dihydrotanshinone I (DI) in inhibiting the growth of human cervical cancer cells both in vitro and in vivo, and molecular targets in HeLa cells when treated by DI or irradiation with or without being combined. " 04/01/2012 - "Combination treatment with dihydrotanshinone I and irradiation enhances apoptotic effects in human cervical cancer by HPV E6 down-regulation and caspases activation." 09/05/2018 - "Biotin-Modified Polylactic- co-Glycolic Acid Nanoparticles with Improved Antiproliferative Activity of 15,16-Dihydrotanshinone I in Human Cervical Cancer Cells."
2.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/2021 - "Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I." 09/10/2016 - "Using this strategy, a combination of four tanshinones (tanshinones IIA, cryptotanshinone, tanshinone I and dihydrotanshinone I), which was as effective as TE in cell models and in a rat model of myocardial ischemia-reperfusion, was identified as ECC in TE. " 12/01/2016 - "The cardioprotection of dihydrotanshinone I against myocardial ischemia-reperfusion injury via inhibition of arachidonic acid ω-hydroxylase."
3.	Reperfusion Injury 01/01/2021 - "Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I." 12/01/2016 - "The cardioprotection of dihydrotanshinone I against myocardial ischemia-reperfusion injury via inhibition of arachidonic acid ω-hydroxylase."
4.	Shock 08/01/2021 - "Importantly, our findings demonstrate that dihydrotanshinone I improved the survival of mice with LPS shock and ameliorated inflammatory responses in septic and gouty animals. "
5.	Muscular Atrophy (Muscle Atrophy) 12/19/2017 - "We found that 15,16-dihydrotanshinone I (DHTS), as a C1-Ten protein tyrosine phosphatase inhibitor, increased IRS-1 stability, improved glucose tolerance and reduced muscle atrophy. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Protein Tyrosine Phosphatases
3.	Propranolol (Inderal)
4.	Biotin (Vitamin H)
5.	glycolic acid (glycolate)
6.	tanshinone
7.	cryptotanshinone
8.	Proteins (Proteins, Gene)
9.	Fatty Acids (Saturated Fatty Acids)
10.	Catenins

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)