Propranolol (Inderal)

A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.

Also Known As:

Networked: 7668 relevant articles (750 outcomes, 953 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Herndon, David N: 18 articles (06/2015 - 08/2002)
2.	Frieden, Ilona J: 11 articles (09/2015 - 09/2009)
3.	Powell, Julie: 11 articles (02/2015 - 03/2011)
4.	Filippi, Luca: 10 articles (05/2015 - 01/2010)
5.	Pitman, Roger K: 10 articles (01/2015 - 01/2002)
6.	Abraldes, Juan G: 9 articles (01/2016 - 12/2002)
7.	García-Pagán, Juan Carlos: 9 articles (09/2015 - 02/2002)
8.	Bosch, Jaume: 8 articles (01/2016 - 02/2002)
9.	Bagnoli, Paola: 8 articles (05/2015 - 01/2010)
10.	Orr, Scott P: 8 articles (01/2015 - 01/2002)

Related Diseases

1.	Hemangioma (Angioma) 10/01/2014 - "The β-blocker propranolol was discovered to be highly effective for the treatment of infantile hemangiomas (IHs), since 2008. " 05/01/2014 - "After initiation of propranolol, most hemangiomas show evidence of significant improvement relatively rapidly, often within days. " 01/01/2014 - "Propranolol is highly effective in the treatment of infantile hemangioma (IH), but important clinical and pharmacological data are lacking. " 01/01/2014 - "Oral propranolol (PRN) has recently been shown to be highly effective for infantile hemangiomas (IHs), and is currently recommended as the first-line treatment of complicated IHs. " 01/01/2013 - "Recent reports of propranolol for the treatment of hemangiomas have led many physicians to question the best treatment strategy for children with vision-threatening hemangiomas. "
2.	Hypertension (High Blood Pressure) 02/01/1986 - "The reduction of heart rate and cardiac index after propranolol were significantly greater in patients with essential hypertension than in control subjects (p less than 0.01, p less than 0.05, respectively). " 01/01/1986 - "Overall, both drugs were safe and effective in treating hypertension, but complaints of beta-blocker-associated side effects were more frequent with propranolol." 01/01/1979 - "In mild to moderately severe hypertension, propranolol, in does of up to 480 mg/day in combination with a thiazide diuretic, has been found to be effective in over 80% of patients on long-term therapy. " 08/01/1983 - "Treatment with propranolol (0.5 mg/kg) eliminated postapnea hypertension. " 04/01/2000 - "The effects of propranolol on cognitive function and quality of life: a randomized trial among patients with diastolic hypertension."
3.	Migraine Disorders (Migraine) 06/01/1990 - "Propranolol at a dosage of 2 mg/kg per day taken divided into three has shown to be the most beneficial in the prevention of migraine headaches. " 06/15/2011 - "The prophylactic effect of propranolol treatment on symptomatic migraine was demonstrated on the HI, which significantly improved (p<0.05). " 01/01/2004 - "Although many trials have relevant methodological shortcomings, there is clear evidence that propranolol is more effective than placebo in the short-term interval treatment of migraine. " 01/01/2004 - "We aimed to determine whether there is evidence that propranolol is more effective than placebo and as effective as other drugs for the interval (prophylactic) treatment of patients with migraine. " 10/01/2009 - "Many clinical trials have confirmed that propranolol is effective in the prophylactic treatment of migraine. "
4.	Hemorrhage 02/01/2006 - "Life-table curves showed that prophylactic EVL and propranolol were similarly effective for primary prophylaxis of variceal bleeding (11/50 [22%]vs 12/50 [24%]; P = 0.68) and overall mortality (14/50 [28%]vs 12/50 [24%]; P = 0.49). " 07/01/1996 - "Two small studies reported that propranolol is effective in arresting mucosal hemorrhage from severe PHG. " 12/01/1988 - "Therapy with oral propranolol was effective in preventing any recurrence of gastrointestinal bleeding." 08/01/2009 - "The evaluation of acute HVPG response to i.v. propranolol before initiating secondary prophylaxis for variceal bleeding is a useful tool in predicting the efficacy of non-selective beta-blockers. " 01/01/2015 - "This large study of children with EHPVO demonstrates the efficacy of propranolol in the reduction of gastrointestinal bleeding in children with EHPVO. "
5.	Angina Pectoris 08/01/1986 - "Seventy three patients (63 males and 10 females) aged 41-75 years with established stable exertional angina pectoris were studied in a double-blind fashion to confirm the efficacy of 80 mg propranolol administered three times daily and also to examine its effect on ST-segment changes in the electrocardiogram by ambulatory ST-segment monitoring and exercise testing using on-line computer analysis. " 06/01/1994 - "Intranasal propranolol has been shown to improve exercise tolerance in patients with angina pectoris. " 11/01/1993 - "Improvement in exercise tolerance and immediate beta-adrenergic blockade with intranasal propranolol in patients with angina pectoris." 02/01/1989 - "[Comparative study of various schedules of administration of propranolol to patients with stenocardia (a cooperative study)]." 04/01/1988 - "In the present study, the incidence and clinical significance of ST-segment fluctuation were studied before and after propranolol in 52 patients with angina pectoris. "

Related Drugs and Biologics

1.	Nifedipine (Adalat)
2.	Verapamil (Calan)
3.	Metoprolol (Lopressor)
4.	Atenolol (Tenormin)
5.	Diltiazem (Cardizem)
6.	Nadolol (Corgard)
7.	Adrenergic Receptors (Adrenergic Receptor)
8.	carvedilol (Coreg)
9.	Propranolol (Inderal)
10.	Isoproterenol (Isoprenaline)

Related Therapies and Procedures

1.	Sclerotherapy
2.	Ligation
3.	Aftercare (After-Treatment)
4.	Drug Therapy (Chemotherapy)
5.	Intravenous Infusions